Origin of Variances in the Oldest-Old: Octogenarian Twins (OCTO-Twin) Våg 4 Origin of Variances in the Oldest-Old: Octogenarian Twins (OCTO-Twin) Wave 4 2021-195-4-1 Swedish National Data Service Svensk nationell datatjänst Origin of Variances in the Oldest-Old: Octogenarian Twins (OCTO-Twin) Våg 4 Origin of Variances in the Oldest-Old: Octogenarian Twins (OCTO-Twin) Wave 4 2021-195-4-1 10.1024/1662-9647/a000138 http://hdl.handle.net/2077/17873 9789162876012 10.1093/gerona/60.5.556 10.1126/science.276.5318.1560 oai:gup.ub.gu.se/266566 10.1093/geronb/gbx170 oai:gup.ub.gu.se/243248 10.1093/geronb/gbw006 oai:DiVA.org:liu-26438 10.1016/S0047-6374(03)00024-1 urn:nbn:se:liu:diva-26438 Hassing, Linda Hassing, Linda Swedish National Data Service Svensk nationell datatjänst NEAR - National E-Infrastructure for Aging Research in Sweden The global increase in life expectancy is one of the greatest achievements of the last half century. However, the demographic development towards an older population poses tremendous societal and medical challenges globally, especially in developed countries such as Sweden. Promoting healthy ageing is therefore one of the most important commitments of the 21st century and to succeed, scientifically based knowledge of older individuals’ health- and care requirements are needed. To better understand the individual and population aging process, the National E-infrastructure for Aging Research (NEAR) was founded in 2018 to build and run a national infrastructure by integrating existing databases from the major population-based longitudinal studies on aging and health in Sweden. NEAR comprises 15 databases located at 8 different universities, which allows comparison, integration, and pooling of data from a large Swedish sample of 180 000 older adults aged 50+ years. NEAR includes information on clinical, biological, social, and environmental data that are assessed at the individual level by physicians, nurses, and psychologists on several occasions during a follow-up period ranging between 12 and 52 years. The creation of a national infrastructures, such as NEAR, is needed to achieve broad, multidisciplinary research perspectives that cannot be achieved by individual databases. Moreover, to address the increased health demands of an older population and enhance new opportunities for aging research, a critical mass of data is needed to increase sample sizes, variations, representativeness, and generalizability. Ultimately, this can lead to the identification of sustainable intervention strategies for better health and care for older persons in Sweden during the coming decades. Den globalt ökade livslängden är en av de senaste halvseklets största landvinningar. Men den demografiska utvecklingen mot en äldre befolkning innebär även enorma samhälleliga och medicinska utmaningar globalt och särskilt i utvecklade länder som Sverige. Att främja ett hälsosamt åldrande är därför en av 2000-talets viktigaste åtaganden och för att lyckas behövs vetenskapligt baserad kunskap om äldres hälsa och vårdbehov. För att bättre förstå åldrandet utifrån ett individuellt samt grupperspektiv grundades den nationella e-infrastrukturen för äldreforskning (NEAR) år 2018. Denna nationella infrastruktur har byggts upp och drivs genom att integrera befintliga databaser från de största populationsbaserade longitudinella studierna om åldrande och hälsa i Sverige. NEAR består av 15 databaser från 8 olika universitet vilket möjliggör jämförelse, integrering och sammanslagning av data från ett stort urval av 180 000 individer som är 50 år och äldre. NEAR tillhandahåller kliniska, biologiska, sociala och miljömässiga data som samlats in på individnivå av läkare, sjuksköterskor och psykologer vid upprepade tillfällen över en uppföljningsperiod som varierar mellan 12 och 52 år. En nationell infrastruktur som NEAR behövs för att uppnå multidisciplinära forskningsperspektiv som inte kan åstadkommas genom användandet av enskilda databaser. För att ta itu med de ökade hälsoutmaningarna som kommer med en åldrande befolkning, samt förbättra nya möjligheter till äldreforskning behövs dessutom en kritisk massa av data för att öka urval, variation, representativitet och generaliserbarhet. I slutändan kan detta leda till utvecklandet av hållbara interventionsstrategier för bättre hälsa och omsorg av äldre i Sverige under de kommande decennierna. Activities of Daily Living Aktiviteter i dagliga livet Aged, 80 and over Äldre, 80 och över Epidemiologic Studies Epidemiologiska studier Dementia Demens Life Style Livsstil Geriatrics Geriatrik Memory Minne Longitudinal Studies Longitudinella studier Neuropsychological Tests Neuropsykologiska tester Socioeconomic Factors Socioekonomiska faktorer Body Mass Index Kroppsmasseindex Genes Gener Cognition Kognition Environment Miljö Depression Depression Personality Personlighet Mental Health Psykisk hälsa Registries Register Diabetes Mellitus, Type 2 Typ 2-diabetes Heredity Ärftlighet Quality of Life Livskvalitet Twin Study Tvillingstudie [Publikationstyp] Aging Åldrande Apolipoproteins E Apolipoproteiner E Memory Disorders Minnesstörningar Nerve Degeneration Nervdegeneration Wechsler Scales Wechslers skalor Degenerative disease of nervous system unspecified Degenerativ sjukdom i nervsystemet (ospecificerad) Mental Status and Dementia Tests Mental status och demenstester Wechsler Memory Scale The OCTO-Twin Study aims to investigate the etiology of individual differences among twin-pairs age 80 and older, on a range of domains including health and functional capacity, cognitive functioning, psychological well-being, personality and personal control. In the study, twin pairs were withdrawn from the Swedish Twin Registry. At the first wave, the twins had to be born 1913 or earlier and both partners in the pair had to accept participation. At baseline in 1991-94, 351 twin pairs (149 monozygotic and 202 like-sex dizygotic pairs) were investigated (mean age: 83.6 years and 67% were female). The two-year longitudinal follow-ups were conducted on all twins who were alive and agreed to participate. Data have been collected at five waves over a total of eight years. In wave 4, 84 twin pairs participated, with a total of 315 individuals. Refer to the description of wave 1/the base line and the individual datasets in the NEAR portal for more details on variable groups and individual variables. OCTO-Twin studien syftar till att undersöka etiologin för individuella skillnader mellan tvillingpar som är 80 år och äldre rörande hälsa, funktionell och kognitiv funktionsförmåga, psykiskt välbefinnande, personlighet och personlig kontroll. I studien identifierades tvillingpar från det svenska befolkningsbaserade tvillingregistret. Vid den första undersökningen var inklusionskriterierna att tvillingarna skulle vara födda år 1913 eller tidigare och att båda partnerna accepterade deltagande. Vid baslinjeundersökningen år 1991-94 undersöktes 351 tvillingpar (149 monozygotiska och 202 dizygotiska par av samma kön) (medelålder: 83,6 år och 67% kvinnor). De tvååriga longitudinella uppföljningarna genomfördes på alla tvillingar som levde och som gick med på att delta. Data har samlats in vid fem tillfällen under totalt åtta år. I våg 4 deltog 86 tvillingpar och totalt 315individer. Se beskrivningen under wave 1/baslinjen och de individuella dataseten i NEAR-portalen för mer detaljer om variabelgrupper och individuella variabler. 1997-04 2000-05 Sweden Sverige IndividualIndividual IndividIndivid Twin pairs from the Swedish Twin Registry who were born 1913 or earlier and were at the age of 80 years at baseline. Tvillingpar från det svenska befolkningsbaserade tvillingregistret, födda år 1913 eller tidigare, som vid inklusion var 80 år eller äldre. Numeric Longitudinal: Trend/Repeated cross-sectionLongitudinal: Trend/Repeated cross-section Longitudinell: Trend/Upprepat tvärsnittLongitudinell: Trend/Upprepat tvärsnitt LongitudinalLongitudinal LongitudinellLongitudinell The participants were examined in their home settings by registered nurses. The participants also answered a number of self-administered surveys.The participants were examined in their home settings by registered nurses. The participants also answered a number of self-administered surveys. Deltagarna undersöktes och intervjuades i sina hem av legitimerade sjuksköterskor. Deltagarna fyllde också i ett antal självadministrerade enkäter.Deltagarna undersöktes och intervjuades i sina hem av legitimerade sjuksköterskor. Deltagarna fyllde också i ett antal självadministrerade enkäter. 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In Mechanisms of Ageing and Development (Vol. 124, Issue 4, pp. 469–476). https://doi.org/10.1016/S0047-6374(03)00024-1 10.1016/S0047-6374(03)00024-1 urn:nbn:se:liu:diva-26438 oai:DiVA.org:liu-26438 2003 oai:DiVA.org:liu-26438