<codeBook xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xsi:schemaLocation="ddi:codebook:2_5 http://www.ddialliance.org/Specification/DDI-Codebook/2.5/XMLSchema/codebook.xsd" xmlns="ddi:codebook:2_5">
  <docDscr>
    <citation>
      <titlStmt>
        <titl xml:lang="sv">X-inaktivering under T-cellsutvecklingen i thymus</titl>
        <parTitl xml:lang="en">A landscape of X-inactivation during human T-cell development in the thymus</parTitl>
        <IDNo agency="SND">2022-112-1-1</IDNo>
        <IDNo agency="DOI">https://doi.org/10.5878/frw5-wd59</IDNo>
      </titlStmt>
      <prodStmt>
        <producer xml:lang="en" abbr="SND">Swedish National Data Service</producer>
        <producer xml:lang="sv" abbr="SND">Svensk nationell datatjänst</producer>
      </prodStmt>
      <holdings URI="https://doi.org/10.5878/frw5-wd59">Landing page</holdings>
    </citation>
  </docDscr>
  <stdyDscr>
    <citation>
      <titlStmt>
        <titl xml:lang="sv">X-inaktivering under T-cellsutvecklingen i thymus</titl>
        <parTitl xml:lang="en">A landscape of X-inactivation during human T-cell development in the thymus</parTitl>
        <IDNo agency="SND">2022-112-1-1</IDNo>
        <IDNo agency="DOI">https://doi.org/10.5878/frw5-wd59</IDNo>
      </titlStmt>
      <rspStmt>
        <AuthEnty xml:lang="en" affiliation="Institute of Clinical Sciences, Department of Pediatrics, University of Gothenburg">Ekwall, Olov</AuthEnty>
        <AuthEnty xml:lang="sv" affiliation="Institutionen för kliniska vetenskaper, Avdelningen för pediatrik, Göteborgs universitet">Ekwall, Olov</AuthEnty>
      </rspStmt>
      <prodStmt>
        <grantNo xml:lang="en" agency="Swedish Research Council">2018-02752</grantNo>
        <grantNo xml:lang="sv" agency="Vetenskapsrådet">2018-02752</grantNo>
        <grantNo xml:lang="en" agency="The ALF agreement: The Swedish state under the ALF agreement between the Swedish government and the county councils">ALFGBG-965795</grantNo>
        <grantNo xml:lang="sv" agency="ALF Västra Götalandsregionen">ALFGBG-965795</grantNo>
      </prodStmt>
      <distStmt>
        <distrbtr xml:lang="en" abbr="SND" URI="https://snd.se">Swedish National Data Service</distrbtr>
        <distrbtr xml:lang="sv" abbr="SND" URI="https://snd.se">Svensk nationell datatjänst</distrbtr>
        <distDate xml:lang="en" date="2022-09-06" />
      </distStmt>
      <verStmt>
        <version elementVersion="1" elementVersionDate="2022-09-06" />
      </verStmt>
      <holdings URI="https://doi.org/10.5878/frw5-wd59">Landing page</holdings>
    </citation>
    <stdyInfo>
      <subject>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D006424">Hemic and Immune Systems</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D006424">Blod- och immunsystem</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D007107">Immune System</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D007107">Immunsystem</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D013504">Cardiovascular Surgical Procedures</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D013504">Kardiovaskulära kirurgiska ingrepp</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D013601">T-Lymphocytes</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D013601">T-lymfocyter</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D013950">Thymus Gland</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D013950">Bräss</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D060168">Thymocytes</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D060168">Tymocyter</keyword>
      </subject>
      <abstract xml:lang="en" contentType="abstract">The aim of the study was to investigate X-inactivation during human T-cell development in the thymus. Thymocytes from six different developmental stages from seven individuals were isolated and studied regarding gene expression. The data set contains data from RNA sequencing, DNA methylation and whole exome sequencing.

The dataset contains data from the manuscript "A landscape of X-inactivation during human T-cell development in the thymus" by Gylemo et al, and consists of results from RNA sequencing (fastq.gz), analysis of DNA methylation (Grn.idat) and whole exome DNA sequencing (fastq.gz) of six developmental stages of thymocytes from seven individuals.

The data is described on individual and cell-type level in the tab-separated metadata files (.tsv).
MD5 checksums for each file are included.</abstract>
      <abstract xml:lang="sv" contentType="abstract">Huvudsyftet med studien har varit att studera X-inaktivering under T-cellsutveckling i human thymus. I studien har sex olika utvecklingsstadier av thymocyter isolerats från sju individer och studerats avseende genuttryck. Datamaterialet innehåller data från RNA-sekvensering, DNA-metylering och helexom-sekvensering av DNA.

Datasetet innehåller data från manuskriptet "A landscape of X-inactivation during human T-cell development in the thymus" av Gylemo et al och innehåller resultat från RNA-sekvensering (fastq.gz), analys av DNA-metylering (Grn.idat) och DNA-exomsekvensering (fastq.gz) av sex olika mognadsstadier av thymocyter från totalt sju individer. 

Data är beskrivna på individ- och celltypsnivå i de bifogade tabbseparerade metadatafilerna (.tsv).
Kontrollsummor i MD5-format för datafilerna finns tillgängliga.</abstract>
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        <nation xml:lang="en" abbr="SE">Sweden</nation>
        <nation xml:lang="sv" abbr="SE">Sverige</nation>
        <anlyUnit xml:lang="en" unit="Cells">Cells<concept vocab="DDI Analysis Unit" vocabURI="https://vocabularies.cessda.eu/v2/vocabularies/AnalysisUnit/2.1.3?languageVersion=en-2.1.3">Cells</concept></anlyUnit>
        <anlyUnit xml:lang="sv" unit="Celler">Celler<concept vocab="DDI Analysis Unit" vocabURI="https://vocabularies.cessda.eu/v2/vocabularies/AnalysisUnit/2.1.3?languageVersion=sv-2.1.3">Celler</concept></anlyUnit>
        <universe xml:lang="en">Isolated thymocytes from seven persons were studied, three boys and four girls, all under 3 yrs that underwent cardiac surgery for correction of congenital heart defects.</universe>
        <universe xml:lang="sv">Isolerade thymocyter från sju personer studerades. Försökspersonerna var tre pojkar och fyra flickor, alla under 3 år, som genomgick korrigerande hjärtkirurgi för medfödda hjärtmissbildningar.</universe>
        <dataKind xml:lang="en">Numeric</dataKind>
        <dataKind xml:lang="en">Text</dataKind>
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    <method>
      <dataColl>
        <sampProc xml:lang="en">Other<concept vocab="DDI Sampling Procedure" vocabURI="https://vocabularies.cessda.eu/v2/vocabularies/SamplingProcedure/2.0.1?languageVersion=en-2.0.1">Other</concept></sampProc>
        <sampProc xml:lang="sv">Övrigt<concept vocab="DDI Sampling Procedure" vocabURI="https://vocabularies.cessda.eu/v2/vocabularies/SamplingProcedure/2.0.1?languageVersion=sv-2.0.1">Övrigt</concept></sampProc>
      </dataColl>
    </method>
    <dataAccs>
      <useStmt>
        <restrctn xml:lang="en">Access to data through SND. Access to data is restricted.</restrctn>
        <restrctn xml:lang="sv">Åtkomst till data via SND. Tillgång till data är begränsad.</restrctn>
        <conditions elementVersion="info:eu-repo-Access-Terms vocabulary">restrictedAccess</conditions>
      </useStmt>
    </dataAccs>
    <othrStdyMat>
      <relPubl>
        <citation>
          <titlStmt>
            <titl xml:lang="sv">Björn Gylemo, Antonio Lentini, Christina Lundqvist, Maike Bensberg, Alessandro Camponeschi, Dora Goldman, Aida Selimović, Olov Ekwall, Colm E. Nestor. (2022). A landscape of X-inactivation during human T-cell development [submitted manuscript].</titl>
            <parTitl xml:lang="en">Björn Gylemo, Antonio Lentini, Christina Lundqvist, Maike Bensberg, Alessandro Camponeschi, Dora Goldman, Aida Selimović, Olov Ekwall, Colm E. Nestor. (2022). A landscape of X-inactivation during human T-cell development [submitted manuscript].</parTitl>
          </titlStmt>
          <distStmt>
            <distDate date="2022">2022</distDate>
          </distStmt>
        </citation>
      </relPubl>
    </othrStdyMat>
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