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            <a:FirstGiven>Pedro Luis</a:FirstGiven>
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              <r:String>Pedro Luis Moura</r:String>
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          <r:AttributeValue>Department of Medicine, Huddinge / Center for Hematology and Regenerative Medicine (HERM), Karolinska Institutet</r:AttributeValue>
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            <a:FirstGiven>Eva</a:FirstGiven>
            <a:LastFamily>Hellström-Lindberg</a:LastFamily>
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              <r:String>Eva Hellström-Lindberg</r:String>
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      <r:Title>
        <r:String xml:lang="sv">10X single-cell RNA sequencing of hematopoietic stem and progenitor cells from a dual SF3B1-mutant MDS-RS patient and a healthy donor</r:String>
        <r:String xml:lang="en">10X single-cell RNA sequencing of hematopoietic stem and progenitor cells from a dual SF3B1-mutant MDS-RS patient and a healthy donor</r:String>
      </r:Title>
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          <r:URN>urn:ddi:se.researchdata:2023-222.Individual-0:2.0</r:URN>
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      </r:Creator>
      <r:Publisher>
        <r:PublisherName>
          <r:String xml:lang="sv">Karolinska Institutet</r:String>
          <r:String xml:lang="en">Karolinska Institutet</r:String>
        </r:PublisherName>
      </r:Publisher>
      <r:Publisher>
        <r:PublisherName>
          <r:String xml:lang="sv">Karolinska Institutet</r:String>
          <r:String xml:lang="en">Karolinska Institutet</r:String>
        </r:PublisherName>
      </r:Publisher>
      <r:PublicationDate>
        <r:SimpleDate>2024-04-18</r:SimpleDate>
      </r:PublicationDate>
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        <r:IdentifierContent>10.48723/tt0e-eq82</r:IdentifierContent>
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    <r:Abstract>
      <r:Content xml:lang="sv">Syftet med denna datainsamling var att bedöma hur det hematopoetiska stam- och progenitorcellsutrymmet hos en patient skiljde sig över tiden och som ett resultat av förändringar i klonal frekvens. Se den engelska beskrivningen för mer information.</r:Content>
      <r:Content xml:lang="en">This dataset consists of 10X single-cell RNA sequencing data of bone marrow cells (CD34+ stem cells) obtained from two clinical visits of a dual SF3B1-mutant MDS-RS patient (Patient 1 in the associated publication: visits at 31 months post-diagnosis, with dominant SF3B1 N626D; and at 118 months post-diagnosis, with dominant SF3B1 K666N) and one healthy bone marrow donor. The objective of this data collection was to assess how the hematopoietic stem and progenitor cell compartment of this patient differed over time and as a result of changes in clonal frequency. 
The dataset is appoximately 80.9 GB and has filetypes txt, rds and fastq.</r:Content>
    </r:Abstract>
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        <r:URN>urn:ddi:se.researchdata:2023-222.TopicalCoverage:2.0</r:URN>
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        <r:Subject xml:lang="sv" controlledVocabularyID="30112" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Basal cancerforskning</r:Subject>
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