<ddi:DDIInstance xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="ddi:instance:3_3 http://ddialliance.org/Specification/DDI-Lifecycle/3.3/XMLSchema/instance.xsd" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:ddi="ddi:instance:3_3" xmlns:r="ddi:reusable:3_3" xmlns:s="ddi:studyunit:3_3" xmlns:d="ddi:datacollection:3_3" xmlns:a="ddi:archive:3_3" xmlns:c="ddi:conceptualcomponent:3_3" xmlns:cm="ddi:comparative:3_3" xmlns:g="ddi:group:3_3" xmlns:l="ddi:logicalproduct:3_3" xmlns:p="ddi:physicaldataproduct:3_3" xmlns:pi="ddi:physicalinstance:3_3" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xhtml="http://www.w3.org/1999/xhtml" xmlns:xml="http://www.w3.org/XML/1998/namespace" isMaintainable="true" scopeOfUniqueness="Agency">
  <r:URN>urn:ddi:se.researchdata:2023-227:1</r:URN>
  <r:Agency>SND</r:Agency>
  <r:ID>2023-227</r:ID>
  <r:Version>1</r:Version>
  <g:ResourcePackage>
    <r:URN>urn:ddi:se.researchdata:2023-227.ResourcePackage:2.0</r:URN>
    <r:OtherMaterialScheme>
      <r:URN>urn:ddi:se.researchdata:2023-227.OtherMaterialScheme:2.0</r:URN>
    </r:OtherMaterialScheme>
    <a:OrganizationScheme>
      <r:URN>urn:ddi:se.researchdata:2023-227.OrganizationScheme-0:2.0</r:URN>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:2023-227.Individual-0:2.0</r:URN>
        <r:UserAttributePair>
          <r:AttributeKey>affiliation</r:AttributeKey>
          <r:AttributeValue>Department of Medicine, Huddinge/ Center for Hematology and Regenerative Medicine (HERM), Karolinska Institutet</r:AttributeValue>
        </r:UserAttributePair>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Pedro Luis</a:FirstGiven>
            <a:LastFamily>Moura</a:LastFamily>
            <a:FullName>
              <r:String>Pedro Luis Moura</r:String>
            </a:FullName>
          </a:IndividualName>
          <a:ResearcherID>
            <a:TypeOfID>ORCID</a:TypeOfID>
            <a:ResearcherIdentification>0000-0002-0493-5394</a:ResearcherIdentification>
          </a:ResearcherID>
        </a:IndividualIdentification>
      </a:Individual>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:2023-227.Individual-0:2.0</r:URN>
        <r:UserAttributePair>
          <r:AttributeKey>affiliation</r:AttributeKey>
          <r:AttributeValue>Department of Medicine, Huddinge / Center for Hematology and Regenerative Medicine (HERM), Karolinska Institutet</r:AttributeValue>
        </r:UserAttributePair>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Eva</a:FirstGiven>
            <a:LastFamily>Hellström-Lindberg</a:LastFamily>
            <a:FullName>
              <r:String>Eva Hellström-Lindberg</r:String>
            </a:FullName>
          </a:IndividualName>
          <a:ResearcherID>
            <a:TypeOfID>ORCID</a:TypeOfID>
            <a:ResearcherIdentification>0000-0002-7839-3743</a:ResearcherIdentification>
          </a:ResearcherID>
        </a:IndividualIdentification>
      </a:Individual>
    </a:OrganizationScheme>
  </g:ResourcePackage>
  <s:StudyUnit>
    <r:URN>urn:ddi:se.researchdata:2023-227.StudyUnit:2.0</r:URN>
    <r:UserID typeOfUserID="datasetIdentifier">2023-227</r:UserID>
    <r:Citation>
      <r:Title>
        <r:String xml:lang="sv">Colony whole genome sequencing of hematopoietic stem and progenitor cell-derived colonies from 2 dual SF3B1-mutant MDS-RS patients</r:String>
        <r:String xml:lang="en">Colony whole genome sequencing of hematopoietic stem and progenitor cell-derived colonies from 2 dual SF3B1-mutant MDS-RS patients</r:String>
      </r:Title>
      <r:Creator>
        <r:CreatorReference>
          <r:URN>urn:ddi:se.researchdata:2023-227.Individual-0:2.0</r:URN>
          <r:TypeOfObject>Individual</r:TypeOfObject>
        </r:CreatorReference>
      </r:Creator>
      <r:Publisher>
        <r:PublisherName>
          <r:String xml:lang="sv">Karolinska Institutet</r:String>
          <r:String xml:lang="en">Karolinska Institutet</r:String>
        </r:PublisherName>
      </r:Publisher>
      <r:Publisher>
        <r:PublisherName>
          <r:String xml:lang="sv">Karolinska Institutet</r:String>
          <r:String xml:lang="en">Karolinska Institutet</r:String>
        </r:PublisherName>
      </r:Publisher>
      <r:PublicationDate>
        <r:SimpleDate>2024-04-18</r:SimpleDate>
      </r:PublicationDate>
      <r:InternationalIdentifier>
        <r:IdentifierContent>10.48723/n8wy-bb08</r:IdentifierContent>
        <r:ManagingAgency controlledVocabularyAgencyName="DOI">DOI</r:ManagingAgency>
      </r:InternationalIdentifier>
    </r:Citation>
    <r:Abstract>
      <r:Content xml:lang="sv">Denna datauppsättning består av helgenomsekvenseringsdata från kolonier erhållna genom kolonibildande analyser och cellodling av FACS-renade hematopoetiska stamceller (HSC), multipotenta progenitorer (MPP), megakaryocyt-erytroida progenitorer (MEP) och granulocyt-monocytprogenitorer (GMP) ) från 2 MDS-RS-patienter, var och en med 2 konkurrerande SF3B1-mutantkloner. Syftet med denna datainsamling var att bedöma den klonala hierarkin och historien för SF3B1-mutationerna.</r:Content>
      <r:Content xml:lang="en">This dataset consists of whole genome sequencing data from single cell-derived colonies obtained through colony-forming assays and culture of FACS-purified hematopoietic stem cells (HSC), multipotent progenitors (MPP), megakaryocyte-erythroid progenitors (MEP) and granulocyte-monocyte progenitors (GMP) from 2 MDS-RS patients, each with 2 competing SF3B1-mutant clones. The objective of this data collection was to assess the clonal hierarchy and history of the SF3B1 mutations.
The dataset is approximately 1.2 GB and has filetypes zip, txt, phy and ojb.</r:Content>
    </r:Abstract>
    <r:Coverage>
      <r:TopicalCoverage>
        <r:URN>urn:ddi:se.researchdata:2023-227.TopicalCoverage:2.0</r:URN>
        <r:Subject xml:lang="en" controlledVocabularyID="1" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Natural Sciences</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="1" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Naturvetenskap</r:Subject>
        <r:Subject xml:lang="en" controlledVocabularyID="106" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Biological Sciences</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="106" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Biologi</r:Subject>
        <r:Subject xml:lang="en" controlledVocabularyID="10604" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Cell Biology</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="10604" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Cellbiologi</r:Subject>
        <r:Subject xml:lang="en" controlledVocabularyID="10609" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Genetics and Genomics</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="10609" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Genetik och genomik</r:Subject>
        <r:Subject xml:lang="en" controlledVocabularyID="10610" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Bioinformatics and Computational Biology</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="10610" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Bioinformatik och beräkningsbiologi</r:Subject>
        <r:Subject xml:lang="en" controlledVocabularyID="30202" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Hematology</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="30202" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Hematologi</r:Subject>
        <r:Subject xml:lang="en" controlledVocabularyID="30112" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Basic Cancer Research</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="30112" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Basal cancerforskning</r:Subject>
      </r:TopicalCoverage>
      <r:SpatialCoverage />
    </r:Coverage>
    <r:AnalysisUnit controlledVocabularyID="AnalysisUnit" controlledVocabularyAgencyName="DDI Alliance">snd.a01</r:AnalysisUnit>
    <r:AnalysisUnitsCovered>
      <r:String xml:lang="en">Cells</r:String>
      <r:String xml:lang="sv">Celler</r:String>
    </r:AnalysisUnitsCovered>
    <a:Archive>
      <r:URN>urn:ddi:se.researchdata:2023-227.Archive:2.0</r:URN>
      <a:ArchiveSpecific>
        <a:Item>
          <a:Access>
            <r:URN>urn:ddi:se.researchdata:2023-227.Archive-ArchiveSpecificType-AccessType:2.0</r:URN>
            <a:TypeOfAccess controlledVocabularyName="info:eu-repo-Access-Terms vocabulary">restrictedAccess</a:TypeOfAccess>
          </a:Access>
          <a:DataFileQuantity>2</a:DataFileQuantity>
        </a:Item>
      </a:ArchiveSpecific>
    </a:Archive>
  </s:StudyUnit>
</ddi:DDIInstance>