Tillägg av melatonin för behandling av endometrios-associerad bäckensmärta - en randomiserad dubbelblindad, placebokontrollerad studie Adjuvant use of melatonin for pain management in endometriosis-associated pelvic pain - a randomized double-blinded, placebo-controlled trial 2023-28-1-1 https://doi.org/10.48723/875f-ma81 Swedish National Data Service Svensk nationell datatjänst Landing page Tillägg av melatonin för behandling av endometrios-associerad bäckensmärta - en randomiserad dubbelblindad, placebokontrollerad studie Adjuvant use of melatonin for pain management in endometriosis-associated pelvic pain - a randomized double-blinded, placebo-controlled trial 2023-28-1-1 https://doi.org/10.48723/875f-ma81 oai:DiVA.org:liu-196852 10.1371/journal.pone.0286182 Marions, Lena Marions, Lena Swedish National Data Service Svensk nationell datatjänst Landing page Endometriosis Endometrios Melatonin Melatonin Purpose: Considering the pharmacological treatment options for endometriosis-associated pain are confined to hormonal therapy and analgesics, we studied the analgesic effect of 20 mg melatonin as an adjuvant therapy in women with endometriosis-associated pain. Methods: This randomized double-blinded, placebo-controlled trial was conducted at the Research Center for Womens’ Health at Södersjukhuset, a university hospital in Stockholm, Sweden. Forty women from 18 to 50 years of age with endometriosis and severe dysmenorrhea with or without chronic pelvic pain were given 20 mg Melatonin or placebo orally daily for two consecutive menstrual cycles or months. The level of pain was recorded daily via questionnaire on the 11-point numeric rating scale. A difference of 1.3 units was considered clinically significant. Clincaltrials.gov nr NCT03782740. Results: Sixteen participants completed the study in the placebo group and 18 in the melatonin group. The difference in endometriosis-associated pain between the groups showed to be non-significant statistically as well as clinically. Conclusion: This randomized, double-blinded, placebo-controlled trial could not show that 20 mg of melatonin given orally at bedtime had better analgesic effect on endometriosis-associated pain as compared with placebo. However, no adverse effects were observed. The dataset consists of a csv fil (RCT_mel_endo.csv) with responses from the survey. Efter en månads screening randomiserades och lottades fyrtio personer med endometrios till 20 mg melatonin eller placebo för två månaders daglig behandling. Den endometriosrelaterade smärtan utvärderades dagligen via frågeformulär liksom intag av analgetika och andra smärtor såsom dypareuni, dysuri, dyschezi. EHP-30 och katastrofiering (PCS) utvärderades också. Ingen skillnad mellan grupperna sågs. För mer info vg se nedan. Dataset består av en csv fil (RCT_mel_endo.csv) med enkätsvar. 2019-08-21 2021-06-27 Sweden Sverige Fyrtio kvinnor, 18-50 år med endometrios och svår mensvärk Forty women from 18 to 50 years of age with endometriosis and severe dysmenorrhea Numeric Self-administered questionnaireSelf-administered questionnaire Självadministrerat frågeformulärSjälvadministrerat frågeformulär Access to data through SND. Access to data is restricted. Åtkomst till data via SND. Tillgång till data är begränsad. restrictedAccess Soderman, L., Böttiger, Y., Edlund, M., Jaernbert-Pettersson, H., & Marions, L. (2023). Adjuvant use of melatonin for pain management in endometriosis-associated pelvic pain-A randomized double-blinded, placebo-controlled trial. In PLOS ONE (Vol. 18, Issue 6). https://doi.org/10.1371/journal.pone.0286182 Soderman, L., Böttiger, Y., Edlund, M., Jaernbert-Pettersson, H., & Marions, L. (2023). Adjuvant use of melatonin for pain management in endometriosis-associated pelvic pain-A randomized double-blinded, placebo-controlled trial. In PLOS ONE (Vol. 18, Issue 6). https://doi.org/10.1371/journal.pone.0286182 10.1371/journal.pone.0286182 oai:DiVA.org:liu-196852 2023 oai:DiVA.org:liu-196852