SUPPLEMENTARY MATERIAL: Transcriptomic analysis reveals pro-inflammatory signatures associated with acute myeloid leukemia progression
type: Dataset
description: Numerous studies have been performed over the last decade to exploit the complexity of genomic and transcriptomic lesions driving the initiation of acute myeloid leukemia (AML). These studies have helped improve risk classification and treatment options. Detailed molecular characterization of longitudinal AML samples is sparse, however; meanwhile, relapse and therapy resistance represent the main challenges in AML care. To this end, we performed transcriptome-wide RNA sequencing of longitudinal diagnosis, relapse, and/or primary resistant samples from 47 adult and 23 pediatric AML patients with known mutational background. Data consists of a supplemental Pdf file and an Excel file with following tables: Supplemental Table 1. Study cohort sample overview Supplemental Table 2. Study cohort sample characteristics Supplemental Table 3. Clinical information Supplemental Table 4. Characteristics of CD34+ BM-control samples Supplemental Table 5. Antibody information Supplemental Table 6. RNA-seq statistics Supplemental Table 7. SNVs and small InDels detected by RNA-seq Supplemental Table 8. Comprised metadata and RNA-seq- and WGS/WES results Supplemental Table 9. Fusion transcripts in R/PR AML Supplemental Table 10. Sample usage for generation of various analyses Supplemental Table 11. DEGs associated with short vs. long EFS Supplemental Table 12. GO-analysis of DEGs between short vs. long EFS-associated samples Supplemental Table 13. Statistics associated with survival analyses Supplemental Table 14. DEGs between patient-matched diagnosis and relapse samples Supplemental Table 15. GO-analysis of DEGs between patient-matched diagnosis and relapse samples Supplemental Table 16. Machine learning model rules for diagnosis and relapse in adult AML Supplemental Table 17. Machine learning model rules for diagnosis and relapse in pediatric AML Supplemental Table 18. Machine learning model rules for diagnosis and relapse in pediatric AML (features merged with TARGET) Supplemental …
citation: CreativeWork
  name: Stratmann, S., Yones, S. A., Garbulowski, M., Sun, J., Skaftason, A., Mayrhofer, M., … Holmfeldt, L. (2022). Transcriptomic analysis reveals proinflammatory signatures associated with acute myeloid leukemia progression. Blood Advances, 6(1), 152–164. https://doi.org/10.1182/bloodadvances.2021004962
conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
conditions of access: info:eu-repo/semantics/openAccess
creative work status: completed
  type: DefinedTerm
  in defined term set: http://publications.europa.eu/resource/authority/dataset-status
  term code: COMPLETED
creator: Svea Stratmann
creator: Sara A. Yones
  type: Person
  affiliation: Uppsala university
  family name: Yones
  given name: Sara A.
creator: Mateusz Garbulowski
creator: Jitong Sun
  type: Person
  affiliation: Uppsala university
  family name: Sun
  given name: Jitong
creator: Aron Skaftason
  type: Person
  affiliation: Karolinska Institutet
  family name: Skaftason
  given name: Aron
creator: Markus Mayrhofer
creator: Nina Norgren
  type: Person
  affiliation: Umeå University
  family name: Norgren
  given name: Nina
creator: Morten Krogh Herlin
  type: Person
  affiliation: Aarhus University
    type: Organization
    department: Department of Clinical Medicine / Department of Pediatrics and Adolescent Medicine
  family name: Herlin
  given name: Morten Krogh
creator: Christer Sundström
creator: Anna Eriksson
creator: Martin Höglund
creator: Josefine Palle
creator: Jonas Abrahamsson
  type: Person
  affiliation: Sahlgrenska Academy at University of Gothenburg
    type: Organization
    department: Department of Pediatrics, Institute of Clinical Sciences
  family name: Abrahamsson
  given name: Jonas
creator: Kirsi Jahnukainen
  type: Person
  affiliation: University of Helsinki and Helsinki University Central Hospital
    type: Organization
    department: Children's Hospital
  family name: Jahnukainen
  given name: Kirsi
creator: Monica Cheng Munthe-Kaas
  type: Person
  affiliation: Norwegian Institute of Public Health
  family name: Munthe-Kaas
  given name: Monica Cheng
creator: Bernward Zeller
  type: Person
  affiliation: Oslo University Hospital
    type: Organization
    department: Division of Pediatric and Adolescent Medicine
  family name: Zeller
  given name: Bernward
creator: Katja Pokrovskaja Tamm
  type: Person
  affiliation: Karolinska Institutet and Karolinska University hospital
    type: Organization
    department: Department of Oncology and Pathology
  family name: Tamm
  given name: Katja Pokrovskaja
creator: Lucia Cavelier
  type: Person
  affiliation: Uppsala university
  family name: Cavelier
  given name: Lucia
date modified: 2024-08-21
date published: 2021-10-05
language: English
is part of: https://doi.org/10.57804/258t-gk79
keywords: Cancer and Oncology
  type: DefinedTerm
  description: Including: Precision Medicine
  term code: 30203
keywords: acute myeloid leukemia
publisher: Uppsala university
distribution: data/supplemental_tables.xlsx
  type: DataDownload
  additional type: data
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 2150852
  encoding format: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
distribution: data/supplemental_text_figures.pdf
  type: DataDownload
  additional type: data
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 4988776
  encoding format: application/pdf
version: 1

PropertyValue
property ID: DOI
value: 10.57804/xryk-dn78

PropertyValue
property ID: URN
value: urn:nbn:se:uu:diva-455314

PropertyValue
property ID: URN
value: urn:nbn:se:uu:diva-427202

PropertyValue
property ID: DOI
value: 10.1182/bloodadvances.2021004962

Svea Stratmann
type: Person
affiliation: Uppsala university
family name: Stratmann
given name: Svea

Uppsala university
type: Organization
department: Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology / Science for Life Laboratory
name: Uppsala University
department: Department of Cell and Molecular Biology / Science for Life Laboratory
department: Department of Cell and Molecular Biology, Computational Biology and Bioinformatics
department: Science for Life Laboratory
department: Department of Immunology, Genetics and Pathology, Clinical and experimental pathology / Science for Life Laboratory
department: Department of Medical Sciences, Haematology
department: Department of Medical Sciences, Haematology / Department of Medical Sciences
department: Department of Women's and Children's Health, Neuropediatrics, Paediatric oncology / Science for Life Laboratory
department: Department of Immunology, Genetics and Pathology / Science for Life Laboratory

Mateusz Garbulowski
type: Person
affiliation: Uppsala university
family name: Garbulowski
given name: Mateusz

Karolinska Institutet
type: Organization
department: Department of Molecular Medicine and Surgery

Markus Mayrhofer
type: Person
affiliation: Uppsala university
family name: Mayrhofer
given name: Markus

Umeå University
type: Organization
department: Department of Molecular Biology, National Bioinformatics Infrastructure Sweden / Science for Life Laboratory

Christer Sundström
type: Person
affiliation: Uppsala university
family name: Sundström
given name: Christer

Anna Eriksson
type: Person
affiliation: Uppsala university
family name: Eriksson
given name: Anna

Martin Höglund
type: Person
affiliation: Uppsala university
family name: Höglund
given name: Martin

Josefine Palle
type: Person
affiliation: Uppsala university
family name: Palle
given name: Josefine

English
type: Language
alternate name: eng

acute myeloid leukemia
type: DefinedTerm
term code: p23156