Data for: Proteomics reveal biomarkers for diagnosis, disease activity and long-term disability outcomes in multiple sclerosis Data for: Proteomics reveal biomarkers for diagnosis, disease activity and long-term disability outcomes in multiple sclerosis 2024-400-1 https://doi.org/10.48360/jcps-gw67 Swedish National Data Service Svensk nationell datatjänst Landing page Data for: Proteomics reveal biomarkers for diagnosis, disease activity and long-term disability outcomes in multiple sclerosis Data for: Proteomics reveal biomarkers for diagnosis, disease activity and long-term disability outcomes in multiple sclerosis 2024-400-1 https://doi.org/10.48360/jcps-gw67 Gustafsson, Mika Gustafsson, Mika Ernerudh, Jan Ernerudh, Jan Olsson, Tomas Olsson, Tomas Swedish National Data Service Svensk nationell datatjänst Landing page Proteomics Proteomik Multiple sclerosis Multipel skleros Specific diseases, disorders and medical conditions Specifika sjukdomar, störningar och medicinska tillstånd The concentration of 1463 proteins were measured using the Olink Explore platform which uses Proximity Extension Assay (PEA) technology. The proteins are preselected from four Olink panels: Explore 384 Cardiometabolic, Explore 384 Inflammation, Explore 384 Neurology, and Explore 384 Oncology. The protein concentrations are given as Olink’s relative protein quantification unit on log2 scale: Normalized Protein Expression (NPX). The NPX values were intensity normalized by Olink. Protein levels were measured in cerebrospinal fluid samples (n = 186) and plasma samples (n = 165) from persons with multiple sclerosis and healthy controls. The dataset was originally published in DiVA and moved to SND in 2024. Koncentrationen av 1463 proteiner mättes med hjälp av Olink Explore-plattformen som använder Proximity Extension Assay (PEA) teknologi. Proteinerna är förvalda från fyra Olink-paneler: Explore 384 Cardiometabolic, Explore 384 Inflammation, Explore 384 Neurology och Explore 384 Oncology. Proteinernas koncentrationer anges som Olinks relativa proteinmängdsenhet på log2-skalan: Normalized Protein Expression (NPX). NPX-värdena normaliserades (intensity normalization) av Olink. Proteinhalten mättes i ryggvätskeprov (n = 186) och plasmaprov (n = 165) från personer med multipel skleros och friska kontroller. Datasetet publicerades ursprungligen i DiVA och flyttades till SND 2024. Cerebrospinal fluid (CSF) samples and plasma samples were taken from 92 persons with CIS or RRMS at Linköping University Hospital, Sweden and 51 persons with CIS or RRMS at the Karolinska University Hospital, Sweden. Everyone fulfilled the revised McDonald criteria from 2010 and 2017 for CIS or Multiple sclerosis (MS). Age-matched healthy controls (HC) were recruited from healthy blood donors (23 at the Linköping University hospital and 20 at the Karolinska University Hospital). Ryggvätskeprov (CSF) och plasmaprov togs från 92 personer med CIS eller RRMS vid Linköpings universitetssjukhus, Sverige, och 51 personer med CIS eller RRMS vid Karolinska Universitetssjukhuset, Sverige. Alla uppfyllde de reviderade McDonald-kriterierna från 2010 och 2017 för CIS eller multipel skleros (MS). Åldersmatchade friska kontroller (HC) rekryterades från friska blodgivare (23 vid Linköpings universitetssjukhus och 20 vid Karolinska Universitetssjukhuset). Numeric Cross-sectionCross-section TvärsnittTvärsnitt Access to data through SND. Access to data is restricted. Åtkomst till data via SND. Tillgång till data är begränsad. restrictedAccess