STAGE - Study of Twin Adults: Genes and Environment STAGE - Study of Twin Adults: Genes and Environment 2024-475-1 Swedish National Data Service Svensk nationell datatjänst STAGE - Study of Twin Adults: Genes and Environment STAGE - Study of Twin Adults: Genes and Environment 2024-475-1 oai:swepub.ki.se:561430 10.1080/14622200802443551 oai:prod.swepub.kib.ki.se:13901239 10.1375/twin.9.6.875 oai:swepub.ki.se:533488 urn:nbn:se:oru:diva-54531 10.1017/thg.2012.104 Magnusson, Patrik Magnusson, Patrik Pedersen, Nancy Pedersen, Nancy 2017-00641, 2021-00180 2017-00641, 2021-00180 Swedish National Data Service Svensk nationell datatjänst The Swedish Twin Registry The Swedish Twin Registry collects, holds and distributes data about twins, for research projects with ethical permission. Svenska tvillingregistret samlar, håller och delar data om tvillingar till etikprövade forskningsprojekt Environment and Public Health Miljö och folkhälsa Phenotype Fenotyp Genetics Genetik Health Hälsa Environment Miljö Twinning, Monozygotic Monozygotisk tvillingbildning Twinning, Dizygotic Dizygotisk tvillingbildning HEALTH HÄLSA Between 2004 and 2006, the Swedish Twin Registry (STR) conducted a nationwide data collection targeting twins born in Sweden between 1959 and 1985. The purpose was to study the most common complex diseases and to measure exposures relevant during young adulthood and midlife. This was the first study within STR to use a web-based questionnaire as the primary method of data collection. The target population included both monozygotic and dizygotic twins, of both same-sex and opposite-sex pairs, provided that both twins had survived at least the first year of life. Approximately 43,000 individuals were contacted. Participants were invited to complete a web-based survey that included questions on, among other topics, common health problems, lifestyle habits, and environmental exposures, with a particular focus on tobacco use and smoking cessation behaviors. As a complement, participants were also offered the opportunity to complete the survey via telephone interview conducted by a trained interviewer. The overall response rate was approximately 60 percent, corresponding to just over 25,000 study participants. The following question areas are included: ADHD Alcohol Allergy and eczema Anxiety Arthritis Asthma Burnout CESD - Center for Epidemiological Studies Depression Chronic fatigue Coffee and tea Depression Eating disorders Education and occupation Epilepsy EPQ - Eysenck Personality Questionnaire GWAS - Genotype data Headache IBS - irritable bowel syndrome Illicit drugs Impulsivity Incontinence/Interstitial cystitis Leadership Medical history Menstrual and reproductive history Nutrition OCD Pain Perfectionism Performance Personality disorder Physical activity Reflux Sexual risk behavior Sleep patterns Smoking and snuffing Stressful trauma TCI - Self-directedness Tics Tourette's Syndrome Mellan 2004 och 2006 genomförde Svenska Tvillingregistret (STR) en nationell datainsamling riktad till tvillingar födda i Sverige mellan 1959 och 1985. Syftet var att studera de vanligaste komplexa sjukdomarna samt att mäta exponeringar som är relevanta under ung vuxenålder och medelålder. Detta var den första studien inom STR där en webbaserad enkät användes som huvudsaklig datainsamlingsmetod. Målpopulationen omfattade både enäggs- och tvåäggstvillingar, oavsett könskombination, under förutsättning att båda syskonen överlevt minst det första levnadsåret. Totalt kontaktades cirka 43 000 individer. Deltagarna inbjöds att besvara en webbenkät som inkluderade frågor om bland annat vanliga hälsoproblem, levnadsvanor och miljöexponeringar, med särskilt fokus på tobaksbruk och rökavvänjningsbeteenden. Som komplement erbjöds även möjlighet att genomföra enkäten via telefonintervju med utbildad intervjuare. Den totala svarsfrekvensen uppgick till cirka 60 procent, motsvarande drygt 25 000 studiedeltagare. Följande frågeområden ingår: ADHD Alkohol Allergi och eksem Artrit Astma CESD - Center for Epidemiological Studies Depression Depression Epilepsi EPQ - Eysenck Personality Questionnaire Fysisk aktivitet GWAS - Genotypdata Huvudvärk IBS - irriterad tarm Droger Impulsivitet Inkontinens/interstitiell cystit Kaffe och te Kronisk trötthet Ledarskap Medicinsk historia Menstruations- och reproduktionshistoria Näring OCD (tvångssyndrom) Perfektionism Prestation Personlighetsstörning Reflux Rökning och snusning Sexuellt riskbeteende Smärta Stressande trauma Sömnmönster TCI - Självstyrning Tics Tourettes syndrom Utbildning och yrke Utbrändhet Ångest Ätstörningar 2004-11 2006-05 Sweden Sverige IndividualIndividual IndividIndivid Family: Household familyFamily: Household family Familj: FamiljehushållFamilj: Familjehushåll Monozygotic and dizygotic twins born in Sweden between 1958 and 1985, both same-sex and opposite-sex. Enäggs- och tvåäggstvillingar födda i Sverige mellan 1958 och 1985, både sam- och olikkönade. Numeric Text LongitudinalLongitudinal LongitudinellLongitudinell Longitudinal: Cohort/Event-basedLongitudinal: Cohort/Event-based Longitudinell: Kohort/HändelsebaseradLongitudinell: Kohort/Händelsebaserad The sample included all twins born in Sweden between 1959 and 1985, based on birth records (born 1959-1972, BIRTH) and the Medical Birth Register (born 1973-1985). Twins who had declined to be contacted or participate in the Swedish Twin Registry, had protected identities, emigrated, or passed away were excluded. Both entire twin pairs and individual twins were asked to participate.The sample included all twins born in Sweden between 1959 and 1985, based on birth records (born 1959-1972, BIRTH) and the Medical Birth Register (born 1973-1985). Twins who had declined to be contacted or participate in the Swedish Twin Registry, had protected identities, emigrated, or passed away were excluded. Both entire twin pairs and individual twins were asked to participate. Urvalet omfattade alla tvillingar födda i Sverige mellan 1959 och 1985, baserat på födelsejournaler (födda 1959-1972, BIRTH) och Medicinska födelseregistret (födda 1973-1985). Tvillingar som hade tackat nej till att kontaktas eller delta i Svenska Tvillingregistret, hade skyddad identitet, utvandrat eller avlidit exkluderades. Både hela tvillingpar och enskilda tvillingar tillfrågades om deltagande.Urvalet omfattade alla tvillingar födda i Sverige mellan 1959 och 1985, baserat på födelsejournaler (födda 1959-1972, BIRTH) och Medicinska födelseregistret (födda 1973-1985). Tvillingar som hade tackat nej till att kontaktas eller delta i Svenska Tvillingregistret, hade skyddad identitet, utvandrat eller avlidit exkluderades. Både hela tvillingpar och enskilda tvillingar tillfrågades om deltagande. Total universe/Complete enumerationTotal universe/Complete enumeration Hela populationen/total räkningHela populationen/total räkning Web-based surveyWeb-based survey WebbenkätWebbenkät Self-administered questionnaireSelf-administered questionnaire Självadministrerat frågeformulärSjälvadministrerat frågeformulär Access to data through an external actor. Access to data is restricted. Åtkomst till data via extern aktör. Tillgång till data är begränsad. restrictedAccess Furberg, H., Lichtenstein, P., Pedersen, N., Thornton, L., Bulik, C., Lerman, C., & Sullivan, P. (2008). The STAGE cohort: A prospective study of tobacco use among Swedish twins. In NICOTINE & TOBACCO RESEARCH (Vol. 10, Issue 12, pp. 1727–1735). https://doi.org/10.1080/14622200802443551 Furberg, H., Lichtenstein, P., Pedersen, N., Thornton, L., Bulik, C., Lerman, C., & Sullivan, P. (2008). The STAGE cohort: A prospective study of tobacco use among Swedish twins. In NICOTINE & TOBACCO RESEARCH (Vol. 10, Issue 12, pp. 1727–1735). https://doi.org/10.1080/14622200802443551 10.1080/14622200802443551 oai:swepub.ki.se:561430 2008 oai:swepub.ki.se:561430 Lichtenstein, P., Sullivan, P., Cnattingius, S., Gatz, M., Johansson, S., Carlstrom, E., Bjork, C., Svartengren, M., Wolk, A., Klareskog, L., de Faire, U., Schalling, M., Palmgren, J., & Pedersen, N. (n.d.). The Swedish Twin Registry in the third millennium: an update. In Twin research and human genetics : the official journal of the International Society for Twin Studies (Vol. 9, Issue 6, pp. 875–882). https://doi.org/10.1375/twin.9.6.875 Lichtenstein, P., Sullivan, P., Cnattingius, S., Gatz, M., Johansson, S., Carlstrom, E., Bjork, C., Svartengren, M., Wolk, A., Klareskog, L., de Faire, U., Schalling, M., Palmgren, J., & Pedersen, N. (n.d.). The Swedish Twin Registry in the third millennium: an update. In Twin research and human genetics : the official journal of the International Society for Twin Studies (Vol. 9, Issue 6, pp. 875–882). https://doi.org/10.1375/twin.9.6.875 10.1375/twin.9.6.875 oai:prod.swepub.kib.ki.se:13901239 2012 oai:prod.swepub.kib.ki.se:13901239