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        <titl xml:lang="sv">Data för: Gut microbiota markers in early childhood are linked to farm living, pets in household and allergy</titl>
        <parTitl xml:lang="en">Data for: Gut microbiota markers in early childhood are linked to farm living, pets in household and allergy</parTitl>
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        <IDNo agency="DOI">https://doi.org/10.5878/j3eq-7y09</IDNo>
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      <titlStmt>
        <titl xml:lang="sv">Data för: Gut microbiota markers in early childhood are linked to farm living, pets in household and allergy</titl>
        <parTitl xml:lang="en">Data for: Gut microbiota markers in early childhood are linked to farm living, pets in household and allergy</parTitl>
        <IDNo agency="SND">2024-480-1</IDNo>
        <IDNo agency="DOI">https://doi.org/10.5878/j3eq-7y09</IDNo>
        <IDNo agency="DOI">10.1371/journal.pone.0313078</IDNo>
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        <AuthEnty xml:lang="en" affiliation="Institute of Biomedicine, University of Gothenburg">Adlerberth, Ingegerd</AuthEnty>
        <AuthEnty xml:lang="sv" affiliation="Institutionen för biomedicin, Göteborgs universitet">Adlerberth, Ingegerd</AuthEnty>
        <AuthEnty xml:lang="en" affiliation="Institute of Biomedicine, University of Gothenburg">Wold, Agnes</AuthEnty>
        <AuthEnty xml:lang="sv" affiliation="Institutionen för biomedicin, Göteborgs universitet">Wold, Agnes</AuthEnty>
        <AuthEnty xml:lang="en" affiliation="Institute of Clinical Sciences, University of Gothenburg">Hesselmar, Bill</AuthEnty>
        <AuthEnty xml:lang="sv" affiliation="Institutionen för kliniska vetenskaper, Göteborgs universitet">Hesselmar, Bill</AuthEnty>
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        <grantNo xml:lang="en" agency="Swedish Medical Research Council">K98-06X-12612-01A</grantNo>
        <grantNo xml:lang="sv" agency="Vetenskapsrådet">K98-06X-12612-01A</grantNo>
        <grantNo xml:lang="en" agency="Health &amp; Medical Care Committee of the Region Västra Götaland (Regional Research &amp; Development funds Västra Götaland region)">VGFOUREG-12007</grantNo>
        <grantNo xml:lang="sv" agency="Regionala FoU-medel Västra Götalandsregionen">VGFOUREG-12007</grantNo>
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        <distrbtr xml:lang="en" abbr="SND" URI="https://snd.se">Swedish National Data Service</distrbtr>
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        <distDate xml:lang="en" date="2024-11-27" />
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    <stdyInfo>
      <subject>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D002648">Child</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D002648">Barn</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D057805">Pets</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D057805">Sällskapsdjur</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D006967">Hypersensitivity</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D006967">Överkänslighet</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D001942">Breast Feeding</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D001942">Amning</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D001419">Bacteria</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D001419">Bakterier</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D007223">Infant</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D007223">Spädbarn</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D007422">Intestines</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D007422">Tarmar</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D015169">Colony Count, Microbial</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D015169">Mikrobiell koloniräkning</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000069196">Gastrointestinal Microbiome</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000069196">Tarmflora</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000089822">Birth Cohort</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000089822">Födelsekohort</keyword>
        <topcClas xml:lang="en" vocab="CESSDA Topic Classification" vocabURI="https://vocabularies.cessda.eu/vocabulary/TopicClassification?code=Health">HEALTH</topcClas>
        <topcClas xml:lang="sv" vocab="CESSDA Topic Classification" vocabURI="https://vocabularies.cessda.eu/vocabulary/TopicClassification?code=Health">HÄLSA</topcClas>
      </subject>
      <abstract xml:lang="en" contentType="abstract">These data underly a study which described longitudinal gut microbiota development during early childhood, and investigated associations with early life exposures and allergy outcomes.

The dataset includes variables on: 

Host factors and early life exposures: sex, parental allergy, farm residence, pet ownership, and breastfeeding 

Gut microbiota development: presence and population counts of selected bacterial groups at 9 timepoints between 3 days and 18 months of age. These data were obtained using quantitative bacterial culture of fecal samples, targeting key facultative and anaerobic bacteria of the infant gut (exception: samples obtained at 3 days of age were not cultured quantitatively and targeted facultative bacteria only). 

Allergy at 3 and 8 years of age: clinical diagnosis of allergy (eczema, food allergy, allergic rhinoconjunctivitis or asthma)</abstract>
      <abstract xml:lang="sv" contentType="abstract">Dessa data ligger till grund för en studie som beskriver tarmflorans utveckling över tid under tidig barndom, och undersöker tarmflorans sammansättning i relation till vissa tidiga exponeringar och till senare allergiutveckling.

Datasetet inkluderar följande variabler:

Värdfaktorer och tidiga exponeringar: kön, hereditet för allergi, uppväxt på bondgård, husdjur och amning.

Tarmfloran: förekomst och populationstal för ett antal olika bakteriegrupper vid 9 provtagningstillfällen mellan 3 dagar och 18 månaders ålder. Bakteriadata är baserade på kvantitativ odling av faecesprover med identifiering av fakultativa och anaeroba bakterier som är vanligt förekommande i den tidiga tarmfloran (undantag prover tagna vid 3 dagars ålder som inte odlades kvantitativt och enbart fakultativa bakterier identifierades i dessa). 

Allergi vid 3 och 8 års ålder: klinisk allergidiagnos (eksem, födoämnesallergi, allergisk rinokonjunktivit eller astma)</abstract>
      <sumDscr>
        <collDate xml:lang="en" date="2005-09" event="start">2005-09</collDate>
        <collDate xml:lang="en" date="2015-05" event="end">2015-05</collDate>
        <nation xml:lang="en" abbr="SE">Sweden</nation>
        <nation xml:lang="sv" abbr="SE">Sverige</nation>
        <anlyUnit xml:lang="en" unit="Individual">Individual<concept vocab="DDI Analysis Unit" vocabURI="https://vocabularies.cessda.eu/v2/vocabularies/AnalysisUnit/2.1.3?languageVersion=en-2.1.3">Individual</concept></anlyUnit>
        <anlyUnit xml:lang="sv" unit="Individ">Individ<concept vocab="DDI Analysis Unit" vocabURI="https://vocabularies.cessda.eu/v2/vocabularies/AnalysisUnit/2.1.3?languageVersion=sv-2.1.3">Individ</concept></anlyUnit>
        <universe xml:lang="en">Children participating in the FARMFLORA birth cohort study. Around half of these children lived on a farm and half in the same rural area. The study followed the children from birth up to 8 years of age.</universe>
        <universe xml:lang="sv">Barn från födelsekohorten FARMFLORA, varav ungefär hälften bodde på en bondgård och hälften i samma region på landsbygden. Barnen följdes från födseln upp till 8 års ålder.</universe>
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      <dataColl>
        <timeMeth xml:lang="en">Longitudinal: Cohort/Event-based<concept vocab="DDI Time Method" vocabURI="https://vocabularies.cessda.eu/v2/vocabularies/TimeMethod/1.2.3?languageVersion=en-1.2.3">Longitudinal: Cohort/Event-based</concept></timeMeth>
        <timeMeth xml:lang="sv">Longitudinell: Kohort/Händelsebaserad<concept vocab="DDI Time Method" vocabURI="https://vocabularies.cessda.eu/v2/vocabularies/TimeMethod/1.2.3?languageVersion=sv-1.2.3">Longitudinell: Kohort/Händelsebaserad</concept></timeMeth>
        <sampProc xml:lang="en">The aim of the FARMFLORA study was to map which factors in the farming environment protect against allergy development. The FARMFLORA birth cohort included 65 children of whom 28 lived on dairy farms and 37 lived in a rural area but not on a farm in the Västra Götaland region in South-West Sweden. Recruitment to the cohort occurred between September 2005 and March 2008, by approaching pregnant women at maternity clinics in the study area. The children included were born at ≥38 weeks of gestation.<concept vocab="DDI Sampling Procedure" vocabURI="https://vocabularies.cessda.eu/v2/vocabularies/SamplingProcedure/2.0.1?languageVersion=en-2.0.1">The aim of the FARMFLORA study was to map which factors in the farming environment protect against allergy development. The FARMFLORA birth cohort included 65 children of whom 28 lived on dairy farms and 37 lived in a rural area but not on a farm in the Västra Götaland region in South-West Sweden. Recruitment to the cohort occurred between September 2005 and March 2008, by approaching pregnant women at maternity clinics in the study area. The children included were born at ≥38 weeks of gestation.</concept></sampProc>
        <sampProc xml:lang="sv">Syftet med FARMFLORA studien var att kartlägga vilka faktorer i bondgårdsmiljön som skyddar mot allergiutveckling. Födelsekohorten FARMFLORA inkluderade 28 barn från familjer på bondgårdar med mjölkproduktion och 37 kontrollbarn från familjer som bodde på landet  men inte på bondgård i Västra Götalandsregionen i sydvästra Sverige. Barnen i kohorten var födda i graviditetsvecka ≥38. Rekrytering till kohorten skedde genom mödravårdscentraler i området mellan september 2005 och mars 2008.<concept vocab="DDI Sampling Procedure" vocabURI="https://vocabularies.cessda.eu/v2/vocabularies/SamplingProcedure/2.0.1?languageVersion=sv-2.0.1">Syftet med FARMFLORA studien var att kartlägga vilka faktorer i bondgårdsmiljön som skyddar mot allergiutveckling. Födelsekohorten FARMFLORA inkluderade 28 barn från familjer på bondgårdar med mjölkproduktion och 37 kontrollbarn från familjer som bodde på landet  men inte på bondgård i Västra Götalandsregionen i sydvästra Sverige. Barnen i kohorten var födda i graviditetsvecka ≥38. Rekrytering till kohorten skedde genom mödravårdscentraler i området mellan september 2005 och mars 2008.</concept></sampProc>
        <collMode xml:lang="en">Fecal samples were collected from children on nine occasions from 3 days to 18 months of age. The samples were subjected to quantative bacterial culture, and key bacteria of the infant gut were identified and quantified (exception: samples obtained at 3 days of age were not cultured quantitatively).

Data on farm residence, pets in the household and parental allergy were registered upon inclusion

Data on breastfeeding was registered by the parents and collected by telephone interviews

Allergy was diagnosed by clinical evaluation of children using set diagnostic criteria for atopic eczema, food allergy, asthma or allergic rhinoconjunctivitis by experienced pediatricians at three and eight years of age<concept vocab="DDI Mode of Collection" vocabURI="https://vocabularies.cessda.eu/v2/vocabularies/ModeOfCollection/5.0.0?languageVersion=en-5.0.0">Fecal samples were collected from children on nine occasions from 3 days to 18 months of age. The samples were subjected to quantative bacterial culture, and key bacteria of the infant gut were identified and quantified (exception: samples obtained at 3 days of age were not cultured quantitatively).

Data on farm residence, pets in the household and parental allergy were registered upon inclusion

Data on breastfeeding was registered by the parents and collected by telephone interviews

Allergy was diagnosed by clinical evaluation of children using set diagnostic criteria for atopic eczema, food allergy, asthma or allergic rhinoconjunctivitis by experienced pediatricians at three and eight years of age</concept></collMode>
        <collMode xml:lang="sv">Fecesprover erhölls från barnen vid 9 provtagningstillfällen mellan 3 dagar och 18 månaders ålder. Fecesprover odlades kvantitativt och bakterier vanligt förekommande i småbarns tarmflora identifierades och kvantifierades (undantag: prover tagna vid 3 dagars ålder odlades inte kvantitativt).

Uppgifter om boende på bondgård, husdjur i hemmet, och allergi hos föräldrarna registrerades i samband med inklusion i studien.

Amningsdata registrerades av föräldrarna och dessa uppgifter samlades in vid telefonintervjuer.

Allergi hos barnen diagnosticerades av erfarna pediatriker i samband med klinisk undersökning vid 3 och 8 års ålder. I förväg fastställda kriterier för diagnos av atopiskt eksem, födoämnesallergi, allergisk rinokonjunktivit och astma tillämpades.<concept vocab="DDI Mode of Collection" vocabURI="https://vocabularies.cessda.eu/v2/vocabularies/ModeOfCollection/5.0.0?languageVersion=sv-5.0.0">Fecesprover erhölls från barnen vid 9 provtagningstillfällen mellan 3 dagar och 18 månaders ålder. Fecesprover odlades kvantitativt och bakterier vanligt förekommande i småbarns tarmflora identifierades och kvantifierades (undantag: prover tagna vid 3 dagars ålder odlades inte kvantitativt).

Uppgifter om boende på bondgård, husdjur i hemmet, och allergi hos föräldrarna registrerades i samband med inklusion i studien.

Amningsdata registrerades av föräldrarna och dessa uppgifter samlades in vid telefonintervjuer.

Allergi hos barnen diagnosticerades av erfarna pediatriker i samband med klinisk undersökning vid 3 och 8 års ålder. I förväg fastställda kriterier för diagnos av atopiskt eksem, födoämnesallergi, allergisk rinokonjunktivit och astma tillämpades.</concept></collMode>
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        <restrctn xml:lang="en">Access to data through SND. Access to data is restricted.</restrctn>
        <restrctn xml:lang="sv">Åtkomst till data via SND. Tillgång till data är begränsad.</restrctn>
        <conditions elementVersion="info:eu-repo-Access-Terms vocabulary">restrictedAccess</conditions>
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        <citation>
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            <titl xml:lang="sv">Ljung A, Gio-Batta M, Hesselmar B, Imberg H, Rabe H, et al. (2024) Gut microbiota markers in early childhood are linked to farm living, pets in household and allergy. PLOS ONE 19(11): e0313078. https://doi.org/10.1371/journal.pone.0313078</titl>
            <parTitl xml:lang="en">Ljung A, Gio-Batta M, Hesselmar B, Imberg H, Rabe H, et al. (2024) Gut microbiota markers in early childhood are linked to farm living, pets in household and allergy. PLOS ONE 19(11): e0313078. https://doi.org/10.1371/journal.pone.0313078</parTitl>
            <IDNo agency="DOI">10.1371/journal.pone.0313078</IDNo>
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            <distDate date="2024">2024</distDate>
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