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        <r:String xml:lang="sv">Data för: Tumörevolution och dynamik i den immuna mikromiljön vid primär och recidiverad mantelcelllymfon (MCL)</r:String>
        <r:String xml:lang="en">Data for: Tumor evolution and immune microenvironment dynamics in primary and relapsed mantle cell lymphoma</r:String>
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          <r:String xml:lang="sv">Karolinska Institutet</r:String>
          <r:String xml:lang="en">Karolinska Institutet</r:String>
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      <r:Publisher>
        <r:PublisherName>
          <r:String xml:lang="sv">Karolinska Institutet</r:String>
          <r:String xml:lang="en">Karolinska Institutet</r:String>
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      <r:PublicationDate>
        <r:SimpleDate>2025-07-15</r:SimpleDate>
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        <r:IdentifierContent>10.48723/kfy8-5r05</r:IdentifierContent>
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      <r:Content xml:lang="sv">Tillgänglighet för data
Datasetet kan endast delas inom Sverige på grund av juridiska restriktioner.

Sammanfattning: 
Mantelcelllymfom (MCL) är en ovanlig men ofta aggressiv typ av B-cellslymfom med hög risk för återfall. För att förstå mekanismerna bakom sjukdomsrelaps använde vi single-cell RNA-sekvensering (scRNAseq) på 20 prover från diagnostiserade/obehandlade (primära, n = 11) och/eller återfallna tumörer (n = 9) från 11 MCL-patienter. Helt genomsekvensering (WGS) utfördes också på tillgängliga prover.

Den totala storleken på den inlagda datan är cirka 1,3 TB. Den innehåller 70 GNU-zippade fastq-filer med rådata och en dokumentationsfil i xlsx-format. Alla fastq-filnamn finns inkluderade i metadatafilen documentation file metadata.xlsx.</r:Content>
      <r:Content xml:lang="en">Data availability
This dataset can only be shared within Sweden due to legal restrictions.

Abstract: 
Mantle cell lymphoma (MCL) is a rare but often aggressive type of B-cell lymphoma with a high risk of relapse. To understand the mechanisms driving disease relapse, we employed single-cell RNA sequencing (scRNAseq) in 20 samples from diagnosed/untreated (primary, n = 11) and/or relapsed tumors (n = 9) from 11 MCL patients. Whole-genome sequencing was also performed on the available samples.

The total size of the deposited data is approximately 1.3 TB. It contains 70 GNU zipped fastq files with raw data and one documentation file in xlsx format. All fastq file names are included in the documentation file metadata.xlsx.</r:Content>
    </r:Abstract>
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        <r:Subject xml:lang="en" controlledVocabularyID="30107" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Medical Genetics and Genomics</r:Subject>
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        <r:Subject xml:lang="en" controlledVocabularyID="30110" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Immunology in the Medical Area</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="30110" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Immunologi inom det medicinska området</r:Subject>
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        <r:Subject xml:lang="sv" controlledVocabularyID="30202" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Hematologi</r:Subject>
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        <r:Keyword xml:lang="en" controlledVocabularyID="D017423" controlledVocabularyName="MeSH">Sequence Analysis, RNA</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="D017423" controlledVocabularyName="MeSH">RNA-sekvensanalys</r:Keyword>
        <r:Keyword xml:lang="en" controlledVocabularyID="D059010" controlledVocabularyName="MeSH">Single-Cell Analysis</r:Keyword>
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