The shared data includes files essential for (1) replicating the microfluidic device known as the Liver-Lobule-Chip (LLoC) for 3D cell cultures, and (2) simulating the velocity, shear stress, and glucose gradients occurring inside the chip.
Dalsbecker, P., Suominen, S., Faridi, M. A., Mahdavi, R., Johansson, J., Hamngren Blomqvist, C., Goksör, M., Aalto-Setala, K., Viiri, L. E., & Adiels, C. B. (2025). An in vivo mimetic liver-lobule-chip (LLoC) for stem cell maturation, and zonation of hepatocyte-like cells on chip. In LAB ON A CHIP (Vol. 25, Issue 17). https://doi.org/10.1039/d4lc00509k
Lever-on-chip för läkemedelstest och skräddarsydda läkemedel
Swedish Foundation for Strategic Research
Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
Omogna celler som efter delning och utmognad ger upphov till vissa cellslag.
Devices designed to recapitulate tissue or organ-level physiology and architect by combining MICROFLUIDICS; MICROFABRICATION; and 3D CELL CULTURE. Microphysiological systems mimic interconnections important in physiological or pathophysiological states of organ(s) and are often used for instance in HIGH THROUGHPUT SCREENING of drugs and factors important in disease modeling.
documentation/LLoC_documentation file.pdf