Liver-Lobule-Chip (LLoC) design
type: Dataset
description: The shared data includes files essential for (1) replicating the microfluidic device known as the Liver-Lobule-Chip (LLoC) for 3D cell cultures, and (2) simulating the velocity, shear stress, and glucose gradients occurring inside the chip.
citation: CreativeWork
  name: Dalsbecker, P., Suominen, S., Faridi, M. A., Mahdavi, R., Johansson, J., Hamngren Blomqvist, C., Goksör, M., Aalto-Setala, K., Viiri, L. E., & Adiels, C. B. (2025). An in vivo mimetic liver-lobule-chip (LLoC) for stem cell maturation, and zonation of hepatocyte-like cells on chip. In LAB ON A CHIP (Vol. 25, Issue 17). https://doi.org/10.1039/d4lc00509k
conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
conditions of access: info:eu-repo/semantics/openAccess
creative work status: completed
  type: DefinedTerm
  in defined term set: http://publications.europa.eu/resource/authority/dataset-status
  term code: COMPLETED
creator: Caroline Adiels
date modified: 2026-04-24
date published: 2026-04-24
funding: Lever-on-chip för läkemedelstest och skräddarsydda läkemedel
  type: Grant
  funder: Swedish Foundation for Strategic Research
language: English
is part of: https://doi.org/10.5878/gghk-5n16
keywords: Other Physics Topics
  type: DefinedTerm
  term code: 10399
keywords: Other Natural Sciences
  type: DefinedTerm
  term code: 10799
keywords: Biophysics
  type: DefinedTerm
  term code: 10307
keywords: Fatty Liver
keywords: Liver Neoplasms
keywords: liver cancer
keywords: pharmacotherapy
keywords: stem cells
keywords: liver diseases
keywords: simulation
keywords: microfluidics
keywords: liver
keywords: biochemistry
keywords: Microphysiological Systems
keywords: Organ-on-a chip
license: https://creativecommons.org/licenses/by/4.0/
publisher: University of Gothenburg
distribution: data/LLoC_3D_16th_Slice.stl
  type: DataDownload
  additional type: data
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 63684
  encoding format: model/stl
distribution: data/LLoC_excl_diff.dxf
  type: DataDownload
  additional type: data
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 85069
  encoding format: image/vnd.dxf
distribution: data/LLoC_lower layer.dxf
  type: DataDownload
  additional type: data
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 47886538
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distribution: data/LLoC_top layer.dxf
  type: DataDownload
  additional type: data
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 101108
  encoding format: image/vnd.dxf
distribution: documentation/LLoC_documentation file.pdf
  type: DataDownload
  additional type: documentation
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 29756
  encoding format: application/pdf
version: 1

PropertyValue
property ID: DOI
value: 10.5878/9x7f-j603

PropertyValue
property ID: DOI
value: 10.1039/d4lc00509k

Caroline Adiels
type: Person
affiliation: University of Gothenburg
family name: Adiels
given name: Caroline

University of Gothenburg
type: Organization
department: Department of Physics

Swedish Foundation for Strategic Research
type: Organization

English
type: Language
alternate name: eng

Fatty Liver
type: DefinedTerm
description: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
term code: D005234

Liver Neoplasms
type: DefinedTerm
description: Tumors or cancer of the LIVER.
term code: D008113

liver cancer
type: DefinedTerm
term code: p17729

pharmacotherapy
type: DefinedTerm
term code: p10851

stem cells
type: DefinedTerm
description: Omogna celler som efter delning och utmognad ger upphov till vissa cellslag.
term code: p13517

liver diseases
type: DefinedTerm
term code: p12934

simulation
type: DefinedTerm
term code: p4787

microfluidics
type: DefinedTerm
term code: p38414

liver
type: DefinedTerm
term code: p11264

biochemistry
type: DefinedTerm
term code: p1375

Microphysiological Systems
type: DefinedTerm
description: Devices designed to recapitulate tissue or organ-level physiology and architect by combining MICROFLUIDICS; MICROFABRICATION; and 3D CELL CULTURE. Microphysiological systems mimic interconnections important in physiological or pathophysiological states of organ(s) and are often used for instance in HIGH THROUGHPUT SCREENING of drugs and factors important in disease modeling.
term code: D000094182