Data for: "Spatial evidence for carcinoma in situ (CIS) as an entity in human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (TSCC)"
type: Dataset
distribution: Landing page for the dataset
title: Data för: "Spatial evidence for carcinoma in situ (CIS) as an entity in human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (TSCC)" @sv
description: Human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (TSCC) is suggested to arise in tonsillar crypts. They also constitute a rare exception in the literature of carcinoma development, as carcinoma in situ (CIS) is not a recognized entity and dysplastic stages are not evident. Here we used spatial transcriptomics (10x Visium) on HPV-associated TSCC, cervical and HPV-independent oral cancer cases on morphological normal, dysplastic and invasive epithelium. Files included were: - histpopathological annotations - spatial data/images as a zip-file - filtered_feautre_bc_matrix.h5-file per sample
description: Humant papillomvirus (HPV) associerade tonsillkarcinom anses ha sitt ursprung från tonsillkryptor och utgör ett undantag i cancerutvecklingsmodellerna, eftersom de inte anses företrädas av in-situförändringar. Här använder vi oss av spatialtranskriptomik (10X Visium) på HPV-associerade tonsill- cervix och HPV-oberoende orala karcinom och undersöker morfologiskt normala, dysplastiska och invasiva epitelceller. Filer som inkluderas i analysen är: - histopatologiska annoteringar - spatialdata/bilder i zip-format - filtered_feautre_bc_matrix.h5 per prov @sv
modified: 2026-02-27T12:20:38.810913Z
issued: 2025-06-09T14:57:02.331072Z
publisher: Karolinska Institutet
theme: HEAL
access rights: NON PUBLIC
qualified attribution: Attribution
  had role: principalInvestigator
  agent: Anders Näsman
    type: Agent
    account: https://orcid.org/0000-0003-4602-4297
    type: PrivateIndividual(s)
contact point: Individual
  fn: Anders Näsman
keyword: Sequence Analysis
keyword: Sekvensanalys @sv
keyword: Human papillomavirus 16
keyword: Humant papillomvirus 16 @sv
keyword: Carcinoma in situ of oral cavity oesophagus and stomach
keyword: Cancer in situ i munhåla, esofagus och magsäck @sv
keyword: Carcinoma in situ: Lip oral cavity and pharynx
keyword: Cancer in situ i läpp (munhåla och svalg) @sv
language: ENG

Landing page for the dataset
type: Distribution
title: Landningssida för datasetet @sv
access URL: Data for: "Spatial evidence for carcinoma in situ (CIS) as an entity in human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (TSCC)"
availability: stable

Karolinska Institutet
type: Agent
type: Academia-ScientificOrganisation
source: https://ror.org/056d84691