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  <r:ID>2025-152</r:ID>
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          <r:AttributeValue>Department of Oncology-Pathology, Karolinska Institutet</r:AttributeValue>
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          <a:IndividualName>
            <a:FirstGiven>Anders</a:FirstGiven>
            <a:LastFamily>Näsman</a:LastFamily>
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              <r:String>Anders Näsman</r:String>
            </a:FullName>
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            <a:ResearcherIdentification>0000-0003-4602-4297</a:ResearcherIdentification>
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    <r:Citation>
      <r:Title>
        <r:String xml:lang="sv">Data för: "Spatial evidence for carcinoma in situ (CIS) as an entity in human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (TSCC)"</r:String>
        <r:String xml:lang="en">Data for: "Spatial evidence for carcinoma in situ (CIS) as an entity in human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (TSCC)"</r:String>
      </r:Title>
      <r:Creator>
        <r:CreatorReference>
          <r:URN>urn:ddi:se.researchdata:2025-152.Individual-0:2.0</r:URN>
          <r:TypeOfObject>Individual</r:TypeOfObject>
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      </r:Creator>
      <r:Publisher>
        <r:PublisherName>
          <r:String xml:lang="sv">Karolinska Institutet</r:String>
          <r:String xml:lang="en">Karolinska Institutet</r:String>
        </r:PublisherName>
      </r:Publisher>
      <r:Publisher>
        <r:PublisherName>
          <r:String xml:lang="sv">Karolinska Institutet</r:String>
          <r:String xml:lang="en">Karolinska Institutet</r:String>
        </r:PublisherName>
      </r:Publisher>
      <r:PublicationDate>
        <r:SimpleDate>2025-06-09</r:SimpleDate>
      </r:PublicationDate>
      <r:InternationalIdentifier>
        <r:IdentifierContent>10.48723/v39q-2169</r:IdentifierContent>
        <r:ManagingAgency controlledVocabularyAgencyName="DOI">DOI</r:ManagingAgency>
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    <r:Abstract>
      <r:Content xml:lang="sv">Humant papillomvirus (HPV) associerade tonsillkarcinom anses ha sitt ursprung från tonsillkryptor och utgör ett undantag i cancerutvecklingsmodellerna, eftersom de inte anses företrädas av in-situförändringar. Här använder vi oss av spatialtranskriptomik (10X Visium) på HPV-associerade tonsill- cervix och HPV-oberoende orala karcinom och undersöker morfologiskt normala, dysplastiska och invasiva epitelceller. Filer som inkluderas i analysen är:

- histopatologiska annoteringar
- spatialdata/bilder i zip-format
- filtered_feautre_bc_matrix.h5 per prov</r:Content>
      <r:Content xml:lang="en">Human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (TSCC) is suggested to arise in tonsillar crypts. They also constitute a rare exception in the literature of carcinoma development, as carcinoma in situ (CIS) is not a recognized entity and dysplastic stages are not evident. Here we used spatial transcriptomics (10x Visium) on HPV-associated TSCC, cervical and HPV-independent oral cancer cases on morphological normal, dysplastic and invasive epithelium. Files included were:

- histpopathological annotations
- spatial data/images as a zip-file
- filtered_feautre_bc_matrix.h5-file per sample</r:Content>
    </r:Abstract>
    <r:Coverage>
      <r:TopicalCoverage>
        <r:URN>urn:ddi:se.researchdata:2025-152.TopicalCoverage:2.0</r:URN>
        <r:Subject xml:lang="en" controlledVocabularyID="ScienceAndTechnology.Biotechnology" controlledVocabularyName="CESSDA Topic Classification">Biotechnology</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="ScienceAndTechnology.Biotechnology" controlledVocabularyName="CESSDA Topic Classification">Bioteknik</r:Subject>
        <r:Subject xml:lang="en" controlledVocabularyID="30203" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Cancer and Oncology</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="30203" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Cancer och onkologi</r:Subject>
        <r:Subject xml:lang="en" controlledVocabularyID="30209" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Infectious Medicine</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="30209" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Infektionsmedicin</r:Subject>
        <r:Subject xml:lang="en" controlledVocabularyID="30223" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Clinical Laboratory Medicine</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="30223" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Klinisk laboratoriemedicin</r:Subject>
        <r:Keyword xml:lang="en" controlledVocabularyID="D017421" controlledVocabularyName="MeSH">Sequence Analysis</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="D017421" controlledVocabularyName="MeSH">Sekvensanalys</r:Keyword>
        <r:Keyword xml:lang="en" controlledVocabularyID="D052162" controlledVocabularyName="MeSH">Human papillomavirus 16</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="D052162" controlledVocabularyName="MeSH">Humant papillomvirus 16</r:Keyword>
        <r:Keyword xml:lang="en" controlledVocabularyID="D00" controlledVocabularyName="ICD-10">Carcinoma in situ of oral cavity oesophagus and stomach</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="D00" controlledVocabularyName="ICD-10">Cancer in situ i munhåla, esofagus och magsäck</r:Keyword>
        <r:Keyword xml:lang="en" controlledVocabularyID="D000" controlledVocabularyName="ICD-10">Carcinoma in situ: Lip oral cavity and pharynx</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="D000" controlledVocabularyName="ICD-10">Cancer in situ i läpp (munhåla och svalg)</r:Keyword>
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      <r:URN>urn:ddi:se.researchdata:2025-152.DataCollection:2.0</r:URN>
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        <d:DataCollectionDate>
          <r:StartDate>2023-01-01</r:StartDate>
          <r:EndDate>2023-12-31</r:EndDate>
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          <r:URN>urn:ddi:se.researchdata:2025-152.CollectionEvent-0-ModeOfCollectionType:2.0</r:URN>
          <d:TypeOfModeOfCollection>Other</d:TypeOfModeOfCollection>
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            <r:Content xml:lang="en">Other</r:Content>
            <r:Content xml:lang="sv">Övrigt</r:Content>
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