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            <a:FirstGiven>Alexios</a:FirstGiven>
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              <r:String>Alexios Matikas</r:String>
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              <r:String>Thomas Hatschek</r:String>
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            <a:FirstGiven>Theodoros</a:FirstGiven>
            <a:LastFamily>Foukakis</a:LastFamily>
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              <r:String>Theodoros Foukakis</r:String>
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      <r:Title>
        <r:String xml:lang="sv">Data för: neoadjuvant palbociklib och endokrin behandling jämfört med kemoterapi vid ER+/HER2- bröstcancer: en randomiserad fas II-studie</r:String>
        <r:String xml:lang="en">Data for: Neoadjuvant palbociclib and endocrine therapy versus chemotherapy in ER+/HER2- breast cancer: a randomized phase II trial</r:String>
      </r:Title>
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        <r:PublisherName>
          <r:String xml:lang="sv">Karolinska Institutet</r:String>
          <r:String xml:lang="en">Karolinska Institutet</r:String>
        </r:PublisherName>
      </r:Publisher>
      <r:Publisher>
        <r:PublisherName>
          <r:String xml:lang="sv">Karolinska Institutet</r:String>
          <r:String xml:lang="en">Karolinska Institutet</r:String>
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        <r:SimpleDate>2025-10-03</r:SimpleDate>
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        <r:IdentifierContent>10.48723/j14a-6r76</r:IdentifierContent>
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      <r:Content xml:lang="sv">Datasetet innehåller hel-exomsekvensering (WES) och RNA-sekvensering (RNA-Seq) i form av FASTQ-filer från tumörprover inom ramen för PREDIX Lum B-studien, en prospektiv randomiserad fas II-studie (ClinicalTrials.gov ID: NCT02603679) utförd vid tre sjukhus i Sverige. Totalt omfattar datasetet 166 WES-prover och 163 RNA-Seq-prover. För WES ingår även matchade normalprover från blod. Metadatan inkluderar anonymiserat patient-ID, behandlingsarm, kön, och  korresponderande WES- och RNA-seq anonymiserade prov-IDn.
Filer är organiserade efter sekvenseringstyp (WES och RNA-Seq), samt en metadatafil med variabler: prövnings-ID, kön, behandlingsarm och filvägar.
Ingen särskild programvara krävs för åtkomst till FASTQ-filer eller metadata. Vidare analys kräver relaterade bioinformatik-verktyg.

Datasetet består av:
- 4 974 FASTQ-filer, komprimerade som GNU zip-filer
- 3 CSV-filer
- 1 readme-fil i TXT-format
Datasetets totala storlek är ca 7,6 TB .</r:Content>
      <r:Content xml:lang="en">The dataset contains whole-exome sequencing (WES) and RNA sequencing (RNA-Seq) FASTQ files derived from tumor tissue samples collected in the PREDIX Lum B clinical trial (prospective randomized phase II, ClinicalTrials.gov ID: NCT02603679) conducted at three hospitals in Sweden. In total, the dataset includes 166 WES samples and 163 RNA-Seq samples. For WES, matched normal blood samples are also included. Metadata file containing patient anonymized ID, treatment arm, gender, and the corresponding WES and RNA-seq sample anonymized IDs.
Files are organized by sequencing type (WES and RNA-Seq), plus a metadata table listing all variables: trial ID, gender, treatment arm, and associated file paths.
No specialized software is required to open the FASTQ files or metadata. Downstream analysis requires related bioinformatics tools.

The dataset consists of:
- 4,974 FASTQ files, compressed as GNU zip files
- 3 CSV files
- 1 readme file in TXT format
The total size of the dataset is approximately 7.6 TB</r:Content>
    </r:Abstract>
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      <r:TopicalCoverage>
        <r:URN>urn:ddi:se.researchdata:2025-192.TopicalCoverage:2.0</r:URN>
        <r:Subject xml:lang="en" controlledVocabularyID="30102" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Pharmacology and Toxicology</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="30102" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Farmakologi och toxikologi</r:Subject>
        <r:Subject xml:lang="en" controlledVocabularyID="30107" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Medical Genetics and Genomics</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="30107" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Medicinsk genetik och genomik</r:Subject>
        <r:Subject xml:lang="en" controlledVocabularyID="30203" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Cancer and Oncology</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="30203" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Cancer och onkologi</r:Subject>
        <r:Keyword xml:lang="en" controlledVocabularyID="urn:ddi:int.cessda.elsst:5f0a8ab5-1c00-4c67-9974-cfa0c019d7b0:4" controlledVocabularyName="ELSST">CHEMOTHERAPY</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="urn:ddi:int.cessda.elsst:5f0a8ab5-1c00-4c67-9974-cfa0c019d7b0:4" controlledVocabularyName="ELSST">KEMOTERAPI</r:Keyword>
        <r:Keyword xml:lang="en" controlledVocabularyID="D018844" controlledVocabularyName="MeSH">Cyclin-Dependent Kinases</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="D018844" controlledVocabularyName="MeSH">Cyklinberoende kinaser</r:Keyword>
        <r:Keyword xml:lang="en" controlledVocabularyID="D020360" controlledVocabularyName="MeSH">Neoadjuvant Therapy</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="D020360" controlledVocabularyName="MeSH">Neoadjuvant behandling</r:Keyword>
        <r:Keyword xml:lang="en" controlledVocabularyID="254837009" controlledVocabularyName="SNOMEDCT">Malignant neoplasm of breast</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="254837009" controlledVocabularyName="SNOMEDCT">malign brösttumör</r:Keyword>
        <r:Keyword xml:lang="en" controlledVocabularyID="416053008" controlledVocabularyName="SNOMEDCT">Estrogen receptor positive tumor</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="416053008" controlledVocabularyName="SNOMEDCT">östrogenreceptorpositiv tumör</r:Keyword>
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        <r:URN>urn:ddi:se.researchdata:2025-192.SpatialCoverage:2.0</r:URN>
        <r:CountryCode>SE</r:CountryCode>
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