<ddi:DDIInstance xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="ddi:instance:3_3 http://ddialliance.org/Specification/DDI-Lifecycle/3.3/XMLSchema/instance.xsd" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:ddi="ddi:instance:3_3" xmlns:r="ddi:reusable:3_3" xmlns:s="ddi:studyunit:3_3" xmlns:d="ddi:datacollection:3_3" xmlns:a="ddi:archive:3_3" xmlns:c="ddi:conceptualcomponent:3_3" xmlns:cm="ddi:comparative:3_3" xmlns:g="ddi:group:3_3" xmlns:l="ddi:logicalproduct:3_3" xmlns:p="ddi:physicaldataproduct:3_3" xmlns:pi="ddi:physicalinstance:3_3" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xhtml="http://www.w3.org/1999/xhtml" xmlns:xml="http://www.w3.org/XML/1998/namespace" isMaintainable="true" scopeOfUniqueness="Agency">
  <r:URN>urn:ddi:se.researchdata:2025-21:1</r:URN>
  <r:Agency>SND</r:Agency>
  <r:ID>2025-21</r:ID>
  <r:Version>1</r:Version>
  <g:ResourcePackage>
    <r:URN>urn:ddi:se.researchdata:2025-21.ResourcePackage:2.0</r:URN>
    <r:OtherMaterialScheme>
      <r:URN>urn:ddi:se.researchdata:2025-21.OtherMaterialScheme:2.0</r:URN>
    </r:OtherMaterialScheme>
    <a:OrganizationScheme>
      <r:URN>urn:ddi:se.researchdata:2025-21.OrganizationScheme-0:2.0</r:URN>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:2025-21.Individual-0:2.0</r:URN>
        <r:UserAttributePair>
          <r:AttributeKey>affiliation</r:AttributeKey>
          <r:AttributeValue>Department of Clinical Neuroscience, Karolinska Institutet</r:AttributeValue>
        </r:UserAttributePair>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Ingrid</a:FirstGiven>
            <a:LastFamily>Skelton Kockum</a:LastFamily>
            <a:FullName>
              <r:String>Ingrid Skelton Kockum</r:String>
            </a:FullName>
          </a:IndividualName>
          <a:ResearcherID>
            <a:TypeOfID>ORCID</a:TypeOfID>
            <a:ResearcherIdentification>0000-0002-0867-4726</a:ResearcherIdentification>
          </a:ResearcherID>
        </a:IndividualIdentification>
      </a:Individual>
    </a:OrganizationScheme>
  </g:ResourcePackage>
  <s:StudyUnit>
    <r:URN>urn:ddi:se.researchdata:2025-21.StudyUnit:2.0</r:URN>
    <r:UserID typeOfUserID="datasetIdentifier">2025-21</r:UserID>
    <r:Citation>
      <r:Title>
        <r:String xml:lang="sv">Antikroppsnivåer mot Epstein Barr-virusantigen och molekylära sekvenshomologa proteinter hos patienter med multipel skleros och kontroller</r:String>
        <r:String xml:lang="en">Antibody levels towards Epstein Barr virus antigens and molecular mimics in multiple sclerosis patients and controls</r:String>
      </r:Title>
      <r:Creator>
        <r:CreatorReference>
          <r:URN>urn:ddi:se.researchdata:2025-21.Individual-0:2.0</r:URN>
          <r:TypeOfObject>Individual</r:TypeOfObject>
        </r:CreatorReference>
      </r:Creator>
      <r:Publisher>
        <r:PublisherName>
          <r:String xml:lang="sv">Karolinska Institutet</r:String>
          <r:String xml:lang="en">Karolinska Institutet</r:String>
        </r:PublisherName>
      </r:Publisher>
      <r:Publisher>
        <r:PublisherName>
          <r:String xml:lang="sv">Karolinska Institutet</r:String>
          <r:String xml:lang="en">Karolinska Institutet</r:String>
        </r:PublisherName>
      </r:Publisher>
      <r:PublicationDate>
        <r:SimpleDate>2025-02-12</r:SimpleDate>
      </r:PublicationDate>
      <r:InternationalIdentifier>
        <r:IdentifierContent>10.48723/0xhc-vp63</r:IdentifierContent>
        <r:ManagingAgency controlledVocabularyAgencyName="DOI">DOI</r:ManagingAgency>
      </r:InternationalIdentifier>
    </r:Citation>
    <r:Abstract>
      <r:Content xml:lang="sv">Dessa data genererades med hjälp av plasmaprover från EIMS-studien (1). Det övergripande målet med EIMS studien är att förstå vilka livstil och genetiska faktorer som påverkar MS risk. Denna delstudies mål var att bättre förstå hur epstein barr virus kan påverka uppkomst av autoimmuna reaktioner. Studien inkluderar data från 661 populationsbaserade kontroller och 650 multipel sklerospatienter från Sverige. Datan består av antikroppsnivåer mätta med fluorescensaktiverad pärlbaserad analys. Prover kördes i duplikat. Nivåerna justerades mellan plattorna med användning av batchkontrollprover. De angivna värdena är medelvärdet av de två körningarna efter batchkorrigering.
HLA-genotyper har imputerats från SNP-genotyper i HlA-regionen av kromosom 6 med hjälp av HLA*IMP:02 som beskrivits tidigare (2).

Datasetet består av följande filer:
- PNAS_Data_combined.csv (433 kB)
- MetaData.csv
- MetaDescription.docx
Mer information om variablerna i tabellerna finns i dokumentationsfilen.</r:Content>
      <r:Content xml:lang="en">This data was generated using plasma samples from the EIMS study (1). The overall goal of the EIMS study is to understand which lifestyle and genetic factors influence MS risk. The aim of this sub-study was to better understand how epstein barr virus can affect the onset of autoimmune reactions. The study includes data from 661 population based controls and 650 multiple sclerosis patients from Sweden. The data consists of antibody levels estimated using fluorescence-activated bead-based assay. Samples were run in duplicate. The levels were adjusted between plates using batch controlled samples. The values given are the average of the two run samples after batch correction.
HLA genotypes have been imputed from SNP genotypes in the HlA region of chromosome 6 using HLA*IMP:02 as described previously (2). 

The dataset contains of the following files:
- PNAS_Data_combined.csv (433 kB)
- MetaData.csv
- MetaDescription.docx
Details about the variables in the tables can be found in the documentation file</r:Content>
    </r:Abstract>
    <r:Coverage>
      <r:TopicalCoverage>
        <r:URN>urn:ddi:se.researchdata:2025-21.TopicalCoverage:2.0</r:URN>
        <r:Subject xml:lang="en" controlledVocabularyID="Health.SpecificDiseasesDisordersAndMedicalConditions" controlledVocabularyName="CESSDA Topic Classification">Specific diseases, disorders and medical conditions</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="Health.SpecificDiseasesDisordersAndMedicalConditions" controlledVocabularyName="CESSDA Topic Classification">Specifika sjukdomar, störningar och medicinska tillstånd</r:Subject>
        <r:Subject xml:lang="en" controlledVocabularyID="30105" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Neurosciences</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="30105" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Neurovetenskaper</r:Subject>
        <r:Subject xml:lang="en" controlledVocabularyID="30110" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Immunology in the Medical Area</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="30110" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Immunologi inom det medicinska området</r:Subject>
        <r:Subject xml:lang="en" controlledVocabularyID="30226" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Autoimmunity and Inflammation</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="30226" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Autoimmunitet och inflammation</r:Subject>
        <r:Keyword xml:lang="en" controlledVocabularyID="D020529" controlledVocabularyName="MeSH">Multiple Sclerosis, Relapsing-Remitting</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="D020529" controlledVocabularyName="MeSH">Remitterande multipel skleros</r:Keyword>
        <r:Keyword xml:lang="en" controlledVocabularyID="G35" controlledVocabularyName="ICD-10">Multiple sclerosis</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="G35" controlledVocabularyName="ICD-10">Multipel skleros</r:Keyword>
      </r:TopicalCoverage>
      <r:SpatialCoverage>
        <r:URN>urn:ddi:se.researchdata:2025-21.SpatialCoverage:2.0</r:URN>
        <r:Description>
          <r:Content xml:lang="en">whole of Sweden</r:Content>
        </r:Description>
        <r:CountryCode>SE</r:CountryCode>
      </r:SpatialCoverage>
      <r:TemporalCoverage>
        <r:URN>urn:ddi:se.researchdata:2025-21.TemporalCoverage:2.0</r:URN>
        <r:ReferenceDate>
          <r:StartDate>2005</r:StartDate>
          <r:EndDate>2024</r:EndDate>
        </r:ReferenceDate>
      </r:TemporalCoverage>
    </r:Coverage>
    <r:AnalysisUnit controlledVocabularyID="AnalysisUnit" controlledVocabularyAgencyName="DDI Alliance">Individual<r:ControlledVocabularyURN>http://rdf-vocabulary.ddialliance.org/cv/AnalysisUnit/2.1.3/2dd4472</r:ControlledVocabularyURN></r:AnalysisUnit>
    <r:AnalysisUnitsCovered>
      <r:String xml:lang="en">Individual</r:String>
      <r:String xml:lang="sv">Individ</r:String>
    </r:AnalysisUnitsCovered>
    <a:Archive>
      <r:URN>urn:ddi:se.researchdata:2025-21.Archive:2.0</r:URN>
      <a:ArchiveSpecific>
        <a:Item>
          <a:Access>
            <r:URN>urn:ddi:se.researchdata:2025-21.Archive-ArchiveSpecificType-AccessType:2.0</r:URN>
            <a:TypeOfAccess controlledVocabularyName="info:eu-repo-Access-Terms vocabulary">restrictedAccess</a:TypeOfAccess>
          </a:Access>
          <a:DataFileQuantity>2</a:DataFileQuantity>
        </a:Item>
      </a:ArchiveSpecific>
    </a:Archive>
  </s:StudyUnit>
</ddi:DDIInstance>