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        <r:String xml:lang="sv">Hypoxia enhances follicle survival and ameliorates markers of metabolic function in human ovarian cortical tissue culture</r:String>
        <r:String xml:lang="en">Hypoxia enhances follicle survival and ameliorates markers of metabolic function in human ovarian cortical tissue culture</r:String>
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          <r:String xml:lang="en">Karolinska Institutet</r:String>
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      <r:Content xml:lang="sv">Det övergripande syftet med denna studie är att undersöka effekterna av in vitro-odling på mänsklig äggstocksvävnad och att optimera odlingssystemet för att studera kemikaliers reproduktionstoxicitet i laboratoriet.

Datasetet är kopplat till en studie som undersöker effekten av in vitro-odling på fragment av äggstockskortex. Totalt sekvenserades 5 prover (dvs. 3 prover i den färska gruppen och 2 prover i den odlade gruppen) som samlats in från 3 patienter i denna studie.

Äggstocksvävnaderna dissocierades till encellssuspension med hjälp av mekaniska och enzymatiska metoder och användes för bibliotekspreparering. Enkelcells-RNAseq-bibliotek förbereddes med hjälp av Chromium Next GEM Single Cell 3’ Reagent Kits v3.1 (10X genomics).

Datasetet innehåller 36 fastq-filer från paired-end RNA-sekvensering, komprimerade med GNUzip (gzip). Datasetet innehåller också en md5sum-fil i txt-format för att validera dataintegriteten. Datasetets totala storlek är ungefär 96 GB.</r:Content>
      <r:Content xml:lang="en">The overall aim of this study is to investigate the effects of in vitro culture on human ovarian tissue, and to optimize the culture system to study the reproductive toxicity of chemicals in the laboratory.

The dataset is connected to a study that investigates the impact of in vitro culture on ovarian cortical fragments. In total 5 samples (i.e., 3 samples in the fresh group and 2 samples in the cultured group) collected from 3 patients were sequenced in this study.

Ovarian tissues were dissociated into single-cell suspension using mechanical and enzymatic methods and used for library preparation. Single cell RNAseq libraries were prepared using Chromium Next GEM Single Cell 3’ Reagent Kits v3.1 (10X genomics).

The dataset contains 36 fastq files from paired-end RNA sequencing, compressed with GNUzip (gzip). The dataset also contains one md5sum file in txt format to validate data integrity and a metadata file. The approximate total size of the dataset is 96 GB.</r:Content>
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