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      <titlStmt>
        <titl xml:lang="sv">Kod och data för "Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis"</titl>
        <parTitl xml:lang="en">Codes and data for "Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis"</parTitl>
        <IDNo agency="SND">2025-273-1</IDNo>
        <IDNo agency="DOI">https://doi.org/10.48723/vany-1s63</IDNo>
      </titlStmt>
      <prodStmt>
        <producer xml:lang="en" abbr="SND">Swedish National Data Service</producer>
        <producer xml:lang="sv" abbr="SND">Svensk nationell datatjänst</producer>
      </prodStmt>
      <holdings URI="https://doi.org/10.48723/vany-1s63">Landing page</holdings>
    </citation>
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  <stdyDscr>
    <citation>
      <titlStmt>
        <titl xml:lang="sv">Kod och data för "Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis"</titl>
        <parTitl xml:lang="en">Codes and data for "Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis"</parTitl>
        <IDNo agency="SND">2025-273-1</IDNo>
        <IDNo agency="DOI">https://doi.org/10.48723/vany-1s63</IDNo>
        <IDNo agency="DOI">10.1038/s41588-025-02405-w</IDNo>
      </titlStmt>
      <rspStmt>
        <AuthEnty xml:lang="en" affiliation="Karolinska Institutet">Yoshizato, Tetsuichi</AuthEnty>
        <AuthEnty xml:lang="sv" affiliation="Karolinska Institutet">Yoshizato, Tetsuichi</AuthEnty>
        <AuthEnty xml:lang="en" affiliation="Department of Medicine, Huddinge / Center for Hematology and Regenerative Medicine (HERM), Karolinska Institutet">Jacobsen, Sten Eirik</AuthEnty>
        <AuthEnty xml:lang="sv" affiliation="Institutionen för Medicin, Huddinge / Centrum för hematologi och regenerativ medicin (HERM), Karolinska Institutet">Jacobsen, Sten Eirik</AuthEnty>
      </rspStmt>
      <prodStmt>
        <grantNo xml:lang="en" agency="Knut and Alice Wallenberg Foundation">KAW 2016.0105, 2015.0195</grantNo>
        <grantNo xml:lang="sv" agency="Knut och Alice Wallenbergs Stiftelse">KAW 2016.0105, 2015.0195</grantNo>
        <grantNo xml:lang="en" agency="Tobias Foundation">4-1122/2014</grantNo>
        <grantNo xml:lang="sv" agency="Tobias Stiftelsen">4-1122/2014</grantNo>
        <grantNo xml:lang="en" agency="Center for Innovative Medicine (CIMED) at Karolinska Institutet">613/06</grantNo>
        <grantNo xml:lang="sv" agency="Centrum för innovativ medicin (CIMED) vid Karolinska Institutet">613/06</grantNo>
        <grantNo xml:lang="en" agency="Swedish Research Council">538-2013-8995, 2015-03561</grantNo>
        <grantNo xml:lang="sv" agency="Vetenskapsrådet">538-2013-8995, 2015-03561</grantNo>
        <grantNo xml:lang="en" agency="Medical Research Council">MC_UU_12009/5</grantNo>
        <grantNo xml:lang="en" agency="Swedish Cancer Society">22 2178 Pj</grantNo>
        <grantNo xml:lang="sv" agency="Cancerfonden">22 2178 Pj</grantNo>
        <grantNo xml:lang="en" agency="Radium Hemmets Research Funds">224132, 244282</grantNo>
        <grantNo xml:lang="sv" agency="Radiumhemmets Forskningsfonder">224132, 244282</grantNo>
        <grantNo xml:lang="en" agency="Dr Åke Olsson Foundation">2021-00087</grantNo>
        <grantNo xml:lang="sv" agency="Dr Åke Olssons stiftelse">2021-00087</grantNo>
      </prodStmt>
      <distStmt>
        <distrbtr xml:lang="en" abbr="SND" URI="https://snd.se">Swedish National Data Service</distrbtr>
        <distrbtr xml:lang="sv" abbr="SND" URI="https://snd.se">Svensk nationell datatjänst</distrbtr>
        <distDate xml:lang="en" date="2025-10-13" />
      </distStmt>
      <verStmt>
        <version elementVersion="1" elementVersionDate="2025-10-13" />
      </verStmt>
      <holdings URI="https://doi.org/10.48723/vany-1s63">Landing page</holdings>
    </citation>
    <stdyInfo>
      <subject>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D006412">Hematopoietic Stem Cells</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D006412">Blodstamceller</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D017422">Sequence Analysis, DNA</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D017422">DNA-sekvensanalys</keyword>
        <keyword xml:lang="en" vocab="ICD-10" vocabURI="https://icd.who.int/browse10/2019/en#/D75.8D">Klonal hematopoes av obestämd potential (CHIP)</keyword>
        <keyword xml:lang="sv" vocab="ICD-10" vocabURI="https://icd.who.int/browse10/2019/en#/D75.8D">Klonal hematopoes av obestämd potential (CHIP) (Fördjupningskod)</keyword>
      </subject>
      <abstract xml:lang="en" contentType="abstract">This dataset consists of code for reproducing the figures and statistical analyses from "Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis" and its input data. The code (scripts.zip) is openly available. The files in the "data" folder contain personal data and can only be accessed after completing an assessment process. There are 12 R script files in scripts.zip, and the input data for these scripts are contained within the "data" folder. The input data are stored in text, Newick, or RDS format. The "data" contains 65 files of approximately 247MB total. The file size and path of each file in "data" can be found in the Data_file_list.txt file. For details on each file and instructions on running the code, please refer to README.pdf.</abstract>
      <abstract xml:lang="sv" contentType="abstract">Denna datauppsättning består av kod för att reproducera siffrorna och statistiska analyserna från "Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis" och dess indata. Koden (scripts.zip) är öppet tillgänglig. Filerna i mappen "data" innehåller personuppgifter och kan endast nås efter att en bedömningsprocess har slutförts. Det finns 12 R-skriptfiler i scripts.zip, och indata för dessa skript finns i mappen "data". Indata lagras i text-, Newick- eller RDS-format. "Data" innehåller 65 filer på totalt cirka 247 MB. Filstorleken och sökvägen för varje fil i "data" finns i filen Data_file_list.txt. För information om varje fil och instruktioner om hur du kör koden, se README.pdf.</abstract>
      <sumDscr>
        <nation xml:lang="en" abbr="SE">Sweden</nation>
        <nation xml:lang="sv" abbr="SE">Sverige</nation>
        <universe xml:lang="en">Healthy individuals with rigorous inclusion criteria ensuring the absence of current or previous blood disorders or cancer and without ongoing treatment with immunosuppressive or other drugs likely to affect hematopoiesis.</universe>
        <universe xml:lang="sv">Friska individer med rigorösa inklusionskriterier som säkerställer frånvaron av nuvarande eller tidigare blodsjukdomar eller cancer och utan pågående behandling med immunsuppressiva eller andra läkemedel som sannolikt påverkar hematopoesen.</universe>
        <dataKind xml:lang="en">Other</dataKind>
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    <method>
      <dataColl>
        <timeMeth xml:lang="en">Longitudinal<concept vocab="DDI Time Method" vocabURI="https://vocabularies.cessda.eu/v2/vocabularies/TimeMethod/1.2.3?languageVersion=en-1.2.3">Longitudinal</concept></timeMeth>
        <timeMeth xml:lang="sv">Longitudinell<concept vocab="DDI Time Method" vocabURI="https://vocabularies.cessda.eu/v2/vocabularies/TimeMethod/1.2.3?languageVersion=sv-1.2.3">Longitudinell</concept></timeMeth>
        <sampProc xml:lang="en">Using bone marrow aspiration samples collected from donors, we performed error-corrected targeted DNA capture sequencing (ECTS), whole-exome sequencing, or single colony whole-genome sequencing to obtain mutation lists.<concept vocab="DDI Sampling Procedure" vocabURI="https://vocabularies.cessda.eu/v2/vocabularies/SamplingProcedure/2.0.1?languageVersion=en-2.0.1">Using bone marrow aspiration samples collected from donors, we performed error-corrected targeted DNA capture sequencing (ECTS), whole-exome sequencing, or single colony whole-genome sequencing to obtain mutation lists.</concept></sampProc>
        <sampProc xml:lang="sv">Med hjälp av benmärgsaspirationsprover insamlade från donatorer utförde vi felkorrigerad riktad DNA-infångningssekvensering (ECTS), hel-exomsekvensering eller helgenomsekvensering av en enda koloni för att erhålla mutationslistor.<concept vocab="DDI Sampling Procedure" vocabURI="https://vocabularies.cessda.eu/v2/vocabularies/SamplingProcedure/2.0.1?languageVersion=sv-2.0.1">Med hjälp av benmärgsaspirationsprover insamlade från donatorer utförde vi felkorrigerad riktad DNA-infångningssekvensering (ECTS), hel-exomsekvensering eller helgenomsekvensering av en enda koloni för att erhålla mutationslistor.</concept></sampProc>
        <sampProc xml:lang="en">Non-probability<concept vocab="DDI Sampling Procedure" vocabURI="https://vocabularies.cessda.eu/v2/vocabularies/SamplingProcedure/2.0.1?languageVersion=en-2.0.1">Non-probability</concept></sampProc>
        <sampProc xml:lang="sv">Icke-sannolikhetsurval<concept vocab="DDI Sampling Procedure" vocabURI="https://vocabularies.cessda.eu/v2/vocabularies/SamplingProcedure/2.0.1?languageVersion=sv-2.0.1">Icke-sannolikhetsurval</concept></sampProc>
      </dataColl>
    </method>
    <dataAccs>
      <useStmt>
        <restrctn xml:lang="en">Access to data through SND. Access to data is restricted.</restrctn>
        <restrctn xml:lang="sv">Åtkomst till data via SND. Tillgång till data är begränsad.</restrctn>
        <conditions elementVersion="info:eu-repo-Access-Terms vocabulary">restrictedAccess</conditions>
      </useStmt>
    </dataAccs>
    <othrStdyMat>
      <relPubl>
        <citation>
          <titlStmt>
            <titl xml:lang="sv">Yoshizato, T., Nilsson, C., Grasso, F. et al. Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis. Nat Genet (2025). https://doi.org/10.1038/s41588-025-02405-w</titl>
            <parTitl xml:lang="en">Yoshizato, T., Nilsson, C., Grasso, F. et al. Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis. Nat Genet (2025). https://doi.org/10.1038/s41588-025-02405-w</parTitl>
            <IDNo agency="DOI">10.1038/s41588-025-02405-w</IDNo>
          </titlStmt>
          <distStmt>
            <distDate date="2025">2025</distDate>
          </distStmt>
        </citation>
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