Raw scRNA-seq FASTQ data files for: Nerve growth factor responsive elements modulate immune cell inflammation and are dysregulated in an Alzheimer's disease mouse model
type: Dataset
description: This dataset contains raw single-cell RNA sequencing (scRNA-seq) FASTQ files generated from splenocytes isolated from wild-type C57BL/6J mice (n = 2). Libraries were prepared using the 10x Genomics Chromium Next GEM Single Cell 3′ Reagent Kit v3.1 and sequenced on an Illumina NextSeq 2000 platform. The dataset consists of paired-end raw sequencing files associated with a study titled "Nerve growth factor responsive elements modulate immune cell inflammation and are dysregulated in an Alzheimer's disease mouse model". The dataset consists of four (4) files: - RGAD_WT_S1_L001_R1_001.fastq.gz Forward reads for WT sample 1 - RGAD_WT_S1_L001_R2_001.fastq.gz Reverse reads for WT sample 1 - RGAD_WT1_S1_L001_R1_001.fastq.gz Forward reads for WT sample 2 - RGAD_WT1_S1_L001_R2_001.fastq.gz Reverse reads for WT sample 2
citation: CreativeWork
  name: Gera, R., Mocci, G., Tambaro, S., Vanlandewijck, M., Nilsson, P., Eriksdotter, M., & Mitra, S. (2026). Nerve growth factor responsive elements modulate immune cell inflammation and are dysregulated in an Alzheimer’s disease mouse model. In Frontiers in Immunology (No. 1722477; Vol. 17). https://doi.org/10.3389/fimmu.2026.1722477
conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
conditions of access: info:eu-repo/semantics/openAccess
creative work status: completed
  type: DefinedTerm
  in defined term set: http://publications.europa.eu/resource/authority/dataset-status
  term code: COMPLETED
creator: Maria Eriksdotter
creator: Ruchi Gera
date modified: 2026-06-11
date published: 2026-04-15
language: English
is part of: https://doi.org/10.48723/63at-p795
keywords: Specific diseases, disorders and medical conditions
keywords: Immunology
  type: DefinedTerm
  term code: 10605
keywords: Inflammation
keywords: Nerve Growth Factors
keywords: Cholinergic Neurons
keywords: Immune cell phenotyping
license: https://creativecommons.org/publicdomain/zero/1.0/
publisher: Karolinska Institutet
distribution: data/RGAD_WT_S1_L001_R1_001.fastq.gz
  type: DataDownload
  additional type: data
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 1756018393
  encoding format: application/gzip
distribution: data/RGAD_WT_S1_L001_R2_001.fastq.gz
  type: DataDownload
  additional type: data
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 4059850934
  encoding format: application/gzip
distribution: data/RGAD_WT1_S1_L001_R1_001.fastq.gz
  type: DataDownload
  additional type: data
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 2352374678
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distribution: data/RGAD_WT1_S1_L001_R2_001.fastq.gz
  type: DataDownload
  additional type: data
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 5317245176
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distribution: documentation/README.txt
  type: DataDownload
  additional type: documentation
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 2070
  encoding format: text/plain
version: 1

PropertyValue
property ID: DOI
value: 10.48723/d5mw-0122

PropertyValue
property ID: DOI
value: 10.3389/fimmu.2026.1722477

Maria Eriksdotter
type: Person
affiliation: Karolinska Institutet
family name: Eriksdotter
given name: Maria

Karolinska Institutet
type: Organization
department: Department of Neurobiology, Care Sciences and Society [H1]

Ruchi Gera
type: Person
affiliation: Karolinska Institutet
family name: Gera
given name: Ruchi

English
type: Language
alternate name: eng

Specific diseases, disorders and medical conditions
type: DefinedTerm
description: Data on specific, diagnosed diseases, disorders or syndromes (often classified in ICD-10 or its earlier versions). For example, medical research on infectious diseases or the causes of diabetes, or data on the physical and mental recovery of people who have had heart surgery.
term code: Health.SpecificDiseasesDisordersAndMedicalConditions

Inflammation
type: DefinedTerm
description: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
term code: D007249

Nerve Growth Factors
type: DefinedTerm
description: Factors which enhance the growth potentialities of sensory and sympathetic nerve cells.
term code: D009414

Cholinergic Neurons
type: DefinedTerm
description: Neurons whose primary neurotransmitter is ACETYLCHOLINE.
term code: D059329

Immune cell phenotyping
type: DefinedTerm
description: Immune cell phenotyping (procedure)
term code: 73259009