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        <r:String xml:lang="sv">Data for: Cellular origin and characterization of autoantibodies against type I IFNs in COVID-19 and APS-1</r:String>
        <r:String xml:lang="en">Data for: Cellular origin and characterization of autoantibodies against type I IFNs in COVID-19 and APS-1</r:String>
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          <r:String xml:lang="sv">Karolinska Institutet</r:String>
          <r:String xml:lang="en">Karolinska Institutet</r:String>
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      <r:Publisher>
        <r:PublisherName>
          <r:String xml:lang="sv">Karolinska Institutet</r:String>
          <r:String xml:lang="en">Karolinska Institutet</r:String>
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      <r:PublicationDate>
        <r:SimpleDate>2026-09-28</r:SimpleDate>
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        <r:IdentifierContent>10.48723/hqay-t924</r:IdentifierContent>
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      <r:Content xml:lang="sv">Autoantikroppar (autoAbs) mot typ I-interferoner (IFN) kan kraftigt försämra det antivirala immunförsvaret vid ett brett spektrum av svåra virusinfektioner. För att undersöka de mekanismer som ligger bakom utvecklingen av dessa autoantikroppar utförde vi kombinerad scRNA-sekvensering (scRNA-seq) och scBCR-sekvensering (scBCR-seq) på sorterade IFN-α2-positiva och IFN-α2-negativa B-celler, tillsammans med scRNA-seq av andra icke-B-immunceller. PBMC:er isolerades från åtta aIFN⁺-patienter med svår covid-19, fem aIFN⁻-patienter med svår covid-19, fem patienter med APS-1 och tio friska donatorer.

Det deponerade datasetet omfattar ungefär 150 filer och en total storlek på 810 GB.</r:Content>
      <r:Content xml:lang="en">Autoantibodies (autoAbs) against type I interferons (IFNs) can severely compromise antiviral defense in a broad range of severe viral infections. To investigate the mechanisms underlying autoantibody development, we performed paired scRNA-seq and scBCR-seq on sorted IFN-α2-positive and IFN-α2-negative B cells, together with scRNA-seq of other non-B immune cells. PBMCs were obtained from eight aIFN⁺ patients with severe COVID-19, five aIFN⁻ patients with severe COVID-19, five patients with APS-1, and ten healthy donors.

The dataset is comprised of about 150 files and a total size of 810 GB.</r:Content>
    </r:Abstract>
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        <r:URN>urn:ddi:se.researchdata:2026-253.TopicalCoverage:2.0</r:URN>
        <r:Subject xml:lang="en" controlledVocabularyID="ScienceAndTechnology.Biotechnology" controlledVocabularyName="CESSDA Topic Classification">Biotechnology</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="ScienceAndTechnology.Biotechnology" controlledVocabularyName="CESSDA Topic Classification">Bioteknik</r:Subject>
        <r:Subject xml:lang="en" controlledVocabularyID="10605" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Immunology</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="10605" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Immunologi</r:Subject>
        <r:Keyword xml:lang="en" controlledVocabularyID="D001327" controlledVocabularyName="MeSH">Autoimmune Diseases</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="D001327" controlledVocabularyName="MeSH">Autoimmuna sjukdomar</r:Keyword>
        <r:Keyword xml:lang="en" controlledVocabularyID="D001402" controlledVocabularyName="MeSH">B-Lymphocytes</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="D001402" controlledVocabularyName="MeSH">B-lymfocyter</r:Keyword>
        <r:Keyword xml:lang="en" controlledVocabularyID="D000086382" controlledVocabularyName="MeSH">COVID-19</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="D000086382" controlledVocabularyName="MeSH">Covid-19</r:Keyword>
        <r:Keyword xml:lang="en" controlledVocabularyID="30621004" controlledVocabularyName="SNOMEDCT">Abs - Autoantibodies</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="30621004" controlledVocabularyName="SNOMEDCT">autoantikropp</r:Keyword>
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          <r:StartDate>2020-12</r:StartDate>
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