Data för: Fibroblast-driven collagen expansion and altered thymic medullary niches in 22q11.2 deletion syndrome Data for: Fibroblast-driven collagen expansion and altered thymic medullary niches in 22q11.2 deletion syndrome 2026-67-1 https://doi.org/10.5878/teyk-ej56 Swedish National Data Service Svensk nationell datatjänst Landing page Data för: Fibroblast-driven collagen expansion and altered thymic medullary niches in 22q11.2 deletion syndrome Data for: Fibroblast-driven collagen expansion and altered thymic medullary niches in 22q11.2 deletion syndrome 2026-67-1 https://doi.org/10.5878/teyk-ej56 10.70962/jhi.20260011 Ekwall, Olov Ekwall, Olov Swedish National Data Service Svensk nationell datatjänst Landing page IMMUNE SYSTEM DISEASES IMMUNSJUKDOMAR Thymus Gland Bräss 22q11 Deletion Syndrome 22q11-deletionssyndrom Other diseases of thymus Andra specificerade sjukdomar i tymus Dysplasia of thymus gland with immunodeficiency tymusdysplasi med immunbrist The aim of the study was to identify spatial transcriptomic and proteomic differences between thymic tissue from patients with 22q11.2 deletion syndrome and controls. Thymic tissue from two patients with 22q11DS and eight controls were subject to spatial transcriptomics and proteomics using Visium and Phenocycler methodologies, respectively. The dataset contains data from the manuscript "Fibroblast-driven collagen expansion and altered thymic medullary niches in 22q11.2 deletion syndrome" by Hennings et al, which was submitted for publication in February 2026. Syftet med studien var att identifiera skillnader avseende spatiala transkriptom och proteom mellan tymusvävnad från patienter med 22q11.2-deletionssyndrom och kontroller. Tymusvävnad från två patienter med 22q11DS och åtta kontroller analyserades med spatial transkriptomik och proteomik med hjälp av Visium- respektive Phenocycler-metodik. Datasetet innehåller data från manuskriptet ”Fibroblast-driven collagen expansion and altered thymic medullary niches in 22q11.2 deletion syndrome” av Hennings et al., som skickades in för publicering i februari 2026. Sweden Sverige CellsCells CellerCeller OrganOrgan OrganOrgan Thymus tissue from ten persons were studied, five boys and five girls, all under 6 months that underwent cardiac surgery for correction of congenital heart defects. Tymusvävnad från tio personer studerades, fem pojkar och fem flickor, alla under 6 månader gamla, som genomgick hjärtkirurgi för korrigering av medfödda hjärtfel. Numeric Text OtherOther ÖvrigtÖvrigt Access to data through SND. Access to data is restricted. Åtkomst till data via SND. Tillgång till data är begränsad. restrictedAccess Viktoria Hennings, Jenny Lingman Framme, Karolina Thörn, Christina Lundqvist, Andri Lemarquis, Solveig Oskarsdottir, Esbjörn Telemo, Åsa Björklund, Olov Ekwall (2026) Fibroblast-driven collagen expansion and altered thymic medullary niches in 22q11.2 deletion syndrome. Accepted for publication, Journal of Human Immunity, https://doi.org/10.70962/jhi.20260011 Viktoria Hennings, Jenny Lingman Framme, Karolina Thörn, Christina Lundqvist, Andri Lemarquis, Solveig Oskarsdottir, Esbjörn Telemo, Åsa Björklund, Olov Ekwall (2026) Fibroblast-driven collagen expansion and altered thymic medullary niches in 22q11.2 deletion syndrome. Accepted for publication, Journal of Human Immunity, https://doi.org/10.70962/jhi.20260011 10.70962/jhi.20260011 2026