Data for: Fibroblast-driven collagen expansion and altered thymic medullary niches in 22q11.2 deletion syndrome
type: Dataset
description: The aim of the study was to identify spatial transcriptomic and proteomic differences between thymic tissue from patients with 22q11.2 deletion syndrome and controls. Thymic tissue from two patients with 22q11DS and eight controls were subject to spatial transcriptomics and proteomics using Visium and Phenocycler methodologies, respectively. The dataset contains data from the manuscript "Fibroblast-driven collagen expansion and altered thymic medullary niches in 22q11.2 deletion syndrome" by Hennings et al, which was submitted for publication in February 2026.
citation: CreativeWork
  name: Viktoria Hennings, Jenny Lingman Framme, Karolina Thörn, Christina Lundqvist, Andri Lemarquis, Solveig Oskarsdottir, Esbjörn Telemo, Åsa Björklund, Olov Ekwall (2026) Fibroblast-driven collagen expansion and altered thymic medullary niches in 22q11.2 deletion syndrome. Accepted for publication, Journal of Human Immunity, https://doi.org/10.70962/jhi.20260011
conditions of access: https://publications.europa.eu/resource/authority/access-right/NON_PUBLIC
conditions of access: info:eu-repo/semantics/restrictedAccess
contributor: Viktoria Hennings
creative work status: completed
  type: DefinedTerm
  in defined term set: http://publications.europa.eu/resource/authority/dataset-status
  term code: COMPLETED
creator: Olov Ekwall
date modified: 2026-04-16
date published: 2026-04-16
funding: Grant
  funder: Swedish Research Council
funding: Grant
  funder: The Swedish governmental funding of clinical research (ALF)
language: English
is part of: https://doi.org/10.5878/hdyt-wd79
keywords: Immunology in the Medical Area
  type: DefinedTerm
  description: Including: Cell and Immunotherapy
  term code: 30110
keywords: Thymus Gland
keywords: 22q11 Deletion Syndrome
keywords: Other diseases of thymus
keywords: Dysplasia of thymus gland with immunodeficiency
publisher: University of Gothenburg
size: QuantitativeValue
  unit text: cases
  value: 10
spatial coverage: Sweden
distribution: documentation/Patient_characteristics_meta.csv
  type: DataDownload
  additional type: documentation
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 413
  encoding format: text/csv
distribution: documentation/Phenocycler_meta.csv
  type: DataDownload
  additional type: documentation
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 908
  encoding format: text/csv
distribution: documentation/Visium_meta.csv
  type: DataDownload
  additional type: documentation
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 2755
  encoding format: text/csv
version: 1

PropertyValue
property ID: DOI
value: 10.5878/teyk-ej56

PropertyValue
property ID: DOI
value: 10.70962/jhi.20260011

Viktoria Hennings
type: Person
affiliation: University of Gothenburg
family name: Hennings
given name: Viktoria

University of Gothenburg
type: Organization
department: Department of Pediatrics, Institute of Clinical Sciences

Olov Ekwall
type: Person
affiliation: University of Gothenburg
family name: Ekwall
given name: Olov

Swedish Research Council
type: Organization

The Swedish governmental funding of clinical research (ALF)
type: Organization

English
type: Language
alternate name: eng

IMMUNE SYSTEM DISEASES
type: DefinedTerm

Thymus Gland
type: DefinedTerm
description: A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
term code: D013950

22q11 Deletion Syndrome
type: DefinedTerm
description: Condition with a variable constellation of phenotypes due to deletion polymorphisms at chromosome location 22q11. It encompasses several syndromes with overlapping abnormalities including the DIGEORGE SYNDROME, VELOCARDIOFACIAL SYNDROME, and CONOTRUNCAL AMOMALY FACE SYNDROME. In addition, variable developmental problems and schizoid features are also associated with this syndrome. (From BMC Med Genet. 2009 Feb 25;10:16) Not all deletions at 22q11 result in the 22q11deletion syndrome.
term code: D058165

Other diseases of thymus
type: DefinedTerm
term code: E328

Dysplasia of thymus gland with immunodeficiency
type: DefinedTerm
description: Dysplasia of thymus gland with immunodeficiency (disorder)
term code: 48119005

Sweden
type: Place