PRONMED Uppsala COVID-19 ICU Biobank
type: Dataset
description: The dataset consists clinical data and biobankes samples from 250 critically ill COVID-19 patients admitted to intensive care at Uppsala University Hospital. During intensive care patients are sampled during weekdays. Wholeblood is collected for DNA sequencing. EDTA- and citrate-plasma, with corresponding cell pellets as well as urine is collected and frozen at -80°C until further use. In addition, PBMCs, PAX tubed for RNA-stabilized blood, and CyTOF tubes for single cell proteomics are collected and frozen. At follow-up after 3-6 months and after 1 year from discharge the corresponding convalescent samples are collected and frozen. All included patients, or next of kin sign an informed consent at the inclusion in the study making it possible to use the samples directly for studies focusing on the genetic, physiological and cellular mechanisms behind the disease and to share samples and data with collaborators both nationally and internationally. Any researcher interested in samples can contact the study to discuss their idea and sample requirements, whereafter material transfer agreements and data transfer agreements can be drafted. For all patients there is detailed clinical information on underlying disease, disease severity, treatment while in ICU and remaining symptoms and physiology at follow-up after 3-6 months and after one year. The dataset includes all routine biochemistry from one year before admission to the ICU until follow-up. There is diagnostic virus quantification for most patients, antibody titers of IgG, IgA and IgM for the SARS-COV-2 spike protein on most patients, and multiplex data on plasma cytokine expression at admission in most patients. In addition all patients have been genotyped as part of the COVID-19 Host Genetics Initiative and most patients have Whole Exome Sequencing data. Clinical patient data are collected in an electronic Case Report Form (eCRF) and stored in a pseudoanonymized database. Genetic and other datasets are identified …
conditions of access: https://publications.europa.eu/resource/authority/access-right/NON_PUBLIC
conditions of access: info:eu-repo/semantics/restrictedAccess
creative work status: completed
  type: DefinedTerm
  in defined term set: http://publications.europa.eu/resource/authority/dataset-status
  term code: COMPLETED
creator: Michael Hultström
  type: Person
  family name: Hultström
  given name: Michael
creator: Robert Frithiof
  type: Person
  family name: Frithiof
  given name: Robert
creator: Miklós Lipcsey
  type: Person
  family name: Lipcsey
  given name: Miklós
date modified: 2021-03-18
date published: 2021-03-18
keywords: Medical and Health Sciences
  type: DefinedTerm
  term code: 3
keywords: Neurosciences
  type: DefinedTerm
  term code: 30105
keywords: Medical Genetics and Genomics
  type: DefinedTerm
  term code: 30107
keywords: Immunology
  type: DefinedTerm
  term code: 10605
keywords: Epidemiology
  type: DefinedTerm
  term code: 30116
keywords: Anaesthesiology
keywords: Medical biochemistry and metabolomics not elsewhere classified
keywords: Sub-acute care
keywords: Acute care
keywords: Epidemiology not elsewhere classified
keywords: Humoural immunology and immunochemistry
keywords: Immunogenetics (incl. genetic immunology)
keywords: Innate immunity
keywords: Intensive care
keywords: Medical genetics (excl. cancer genetics)
keywords: Molecular targets
keywords: Nephrology and urology
keywords: Neurosciences not elsewhere classified
keywords: Respiratory diseases
publisher: Uppsala University
version: 0

PropertyValue
property ID: DOI
value: 10.17044/SCILIFELAB.14229410

Uppsala University
type: Organization