Archaic humans have contributed to large-scale variation in modern human T cell receptor genes
type: Dataset
distribution: Landing page for the dataset
description: The dataset contains the repertoire sequencing data from 45 adult volunteers. For each case 4 separate TCR repseq libraries were constructed after cDNA synthesis using a UMI containing primer located in the constant exon of the TRA, TRD, TRB and TRG genes respectively. In each case a 5’ multiplex set of primers specific for the leader regions of the V genes of either TRA, TRD, TRB or TRG genes was used along with a universal reverse primer, introduced during the cDNA synthesis step to produce the gene specific repseq library. The libraries were sequenced using the Illumina 2 x 300 cycle MiSeq system at the Karlsson Hedestam Laboratory at the Department of Microbiology, Tumor and Cell Biology at Biomedicum, Karolinska Institutet, Stockholm. Terms for access The datasets are only to be used for research that is seeking to advance the understanding of the influence of TCR genetic variation on human biology.
modified: 2024-12-13T00:00:00Z
issued: 2023-03-17T00:00:00Z
publisher: Karolinska Institutet
theme: HEAL
access rights: NON PUBLIC
qualified attribution: Attribution
  had role: principalInvestigator
  agent: Martin Corcoran
    type: Agent
    type: PrivateIndividual(s)
qualified attribution: Attribution
  had role: principalInvestigator
  agent: Mark Chernyshev
    type: Agent
    type: PrivateIndividual(s)
qualified attribution: Attribution
  had role: principalInvestigator
  agent: Marco Mandolesi
    type: Agent
    type: PrivateIndividual(s)
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  had role: principalInvestigator
  agent: Sanjana Narang
    type: Agent
    type: PrivateIndividual(s)
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  had role: principalInvestigator
  agent: Mateusz Kaduk
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    type: PrivateIndividual(s)
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  had role: principalInvestigator
  agent: Christopher Sundling
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    type: PrivateIndividual(s)
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  had role: principalInvestigator
  agent: Anna Färnert
    type: Agent
    type: PrivateIndividual(s)
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  had role: principalInvestigator
  agent: Carolina Bernhardsson
    type: Agent
    type: PrivateIndividual(s)
qualified attribution: Attribution
  had role: principalInvestigator
  agent: Maximilian Larena
    type: Agent
    type: PrivateIndividual(s)
qualified attribution: Attribution
  had role: principalInvestigator
  agent: Mattias Jakobsson
    type: Agent
    type: PrivateIndividual(s)
qualified attribution: Attribution
  had role: principalInvestigator
  agent: Gunilla B. Karlsson Hedestam
    type: Agent
    type: PrivateIndividual(s)
keyword: Genetic immunology

Landing page for the dataset
type: Distribution
title: Landningssida för datasetet @sv
access URL: Archaic humans have contributed to large-scale variation in modern human T cell receptor genes
availability: stable

Karolinska Institutet
type: Agent
type: Academia-ScientificOrganisation
source: https://ror.org/056d84691