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        <r:String xml:lang="en">Archaic humans have contributed to large-scale variation in modern human T cell receptor genes</r:String>
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          <r:String xml:lang="sv">Karolinska Institutet</r:String>
          <r:String xml:lang="en">Karolinska Institutet</r:String>
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          <r:String xml:lang="sv">Karolinska Institutet</r:String>
          <r:String xml:lang="en">Karolinska Institutet</r:String>
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        <r:SimpleDate>2023-03-17</r:SimpleDate>
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      <r:Content xml:lang="en">The dataset contains the repertoire sequencing data from 45 adult volunteers.

For
 each case 4 separate TCR repseq libraries were constructed after cDNA 
synthesis using a UMI containing primer located in the constant exon of 
the TRA, TRD, TRB and TRG genes respectively. In each case a 5’ 
multiplex set of primers specific for the leader regions of the V genes 
of either TRA, TRD, TRB or TRG genes was used along with a universal 
reverse primer, introduced during the cDNA synthesis step to produce the
 gene specific repseq library.

The
 libraries were sequenced using the Illumina 2 x 300 cycle MiSeq system 
at the Karlsson Hedestam Laboratory at the Department of Microbiology, 
Tumor and Cell Biology at Biomedicum, Karolinska Institutet, Stockholm. 

Terms for access

The
 datasets are only to be used for research that is seeking to advance 
the understanding of the influence of TCR genetic variation on human 
biology.</r:Content>
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