WGS in familial chronic lymphocytic leukemia
type: Dataset
description: Data Set Description This repository contains data from a study of three families in which two or more siblings developed chronic lymphocytic leukemia (CLL). Informed consent was provided in accordance with the declaration of Helsinki and the study was approved by the hospital medical ethics committee (METC2015-741). The data consists of BAM-files from whole-genome sequencing (WGS) of nine individuals with data from tumor and matched normal tissue. WGS libraries where prepared using the TruSeq Nano Kit (Illumina Inc.) and sequenced in paired-end mode (2x150bp) on the Illumina HiSeqX Ten system (Illumina Inc.) with 30x target coverage. Reads from each library were aligned to the Grch37 reference genome using BWA mem and merged and de-duplicated using Picard. Re-alignment around known and novel indel-sites was performed with GATK. All SAM/BAM-conversion steps were completed using SAMtools. The repository also contains results from Sanger sequencing of the immunoglobulin rearrangements from the tumor samples. The data is under restricted access and can be accessed upon request through the email-adress below. Terms for accessThe WGS datasets are only to be used for research aimed at advancing the understanding of genetic factors in the development of familial chronic lymphocytic leukemia. Applications aimed at method development including bioinformatics would not be considered as acceptable for use of this dataset.
conditions of access: https://publications.europa.eu/resource/authority/access-right/NON_PUBLIC
conditions of access: info:eu-repo/semantics/restrictedAccess
creative work status: completed
  type: DefinedTerm
  in defined term set: http://publications.europa.eu/resource/authority/dataset-status
  term code: COMPLETED
creator: Viktor Ljungström
  type: Person
  affiliation: Science for Life Laboratory
  family name: Ljungström
  given name: Viktor
creator: Richard Rosenquist Brandell
  type: Person
  affiliation: Science for Life Laboratory
  family name: Rosenquist Brandell
  given name: Richard
date modified: 2023-06-01
date published: 2021-08-26
keywords: Medical and Health Sciences
  type: DefinedTerm
  term code: 3
keywords: Hematology
  type: DefinedTerm
  term code: 30202
keywords: Cancer and Oncology
  type: DefinedTerm
  term code: 30203
keywords: Cancer genetics
keywords: Haematology
publisher: Karolinska Institutet
version: 0

PropertyValue
property ID: DOI
value: 10.17044/SCILIFELAB.14932062

Science for Life Laboratory
type: Organization

Karolinska Institutet
type: Organization