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    <r:Citation>
      <r:Title>
        <r:String xml:lang="en">Hyperthermia-induced in situ drug amorphization by superparamagnetic nanoparticles in oral dosage forms</r:String>
      </r:Title>
      <r:Creator>
        <r:CreatorReference>
          <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-19154459.Individual-0:2.0</r:URN>
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      <r:Publisher>
        <r:PublisherName>
          <r:String xml:lang="sv">Uppsala universitet</r:String>
          <r:String xml:lang="en">Uppsala University</r:String>
        </r:PublisherName>
      </r:Publisher>
      <r:Publisher>
        <r:PublisherName>
          <r:String xml:lang="sv">Uppsala universitet</r:String>
          <r:String xml:lang="en">Uppsala University</r:String>
        </r:PublisherName>
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      <r:PublicationDate>
        <r:SimpleDate>2022-02-18</r:SimpleDate>
      </r:PublicationDate>
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        <r:IdentifierContent>10.17044/SCILIFELAB.19154459</r:IdentifierContent>
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    <r:Abstract>
      <r:Content xml:lang="en">Superparamagnetic iron oxide nanoparticles (SPIONs)
generate heat upon exposure to an alternating magnetic field (AMF) which has
been studied for hyperthermia treatment and triggered drug release. This study
introduces a novel application of magnetic hyperthermia to induce amorphization
of a poorly aqueous soluble drug, celecoxib, in situ in tablets for oral administration. In situ
amorphization can overcome the drug development hurdle of poor aqueous
solubility by molecularly dispersing the drug in a polymeric network inside a
tablet. However, current shortcomings of this approach include low drug loading
in the tablets, toxicity of enabling excipients, and drug degradation. Here,
SPIONs produced by flame spray pyrolysis are compacted with polyvinylpyrolidone
and celecoxib, and exposed to an AMF. The degree of amorphization is strongly
linked to the maximum tablet temperature achieved during AMF exposure, which
depends on SPION composition and content in the tablets. Manganese ferrites
exhibit no toxicity in human intestinal Caco-2 cell lines and are more
effective than zinc ferrites in inducing complete amorphization of celecoxib.
The resulting rapid dissolution and high solubility of in situ amorphized celecoxib in biorelevant intestinal fluid
demonstrates the promising capability of SPIONs as enabling excipients to
magnetically induce amorphization in
situ in oral dosage forms.</r:Content>
    </r:Abstract>
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        <r:Subject xml:lang="sv" controlledVocabularyID="3" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Medicin och hälsovetenskap</r:Subject>
        <r:Subject xml:lang="en" controlledVocabularyID="21003" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Nanotechnology for Materials Science</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="21003" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Nanoteknisk materialvetenskap</r:Subject>
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        <r:Subject xml:lang="sv" controlledVocabularyID="30101" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Farmaceutiska vetenskaper</r:Subject>
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