Activating mutations remodeled the chromatin accessibility landscape to drive distinct regulatory networks in KMT2A-rearranged acute leukemia associated with immune evasion
type: Dataset
description: This dataset includes ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) of five infants with acute lymphoblastic leukemia. All patients had an underlying rearrangement of the KMT2A genes, either KMT2A::MLLT1 (n=1), KMT2A::AFF1 (n=3), or KMT2A::MLLT10 (n=1). Three patients also had activating mutations of NRAS G13D and/or KRAS G12D. The median age of the cohort was 2 months 7 days. Diagnostic sample from bone marrow underwent the ATAC-seq library preparation and sequenced on the NextSeq 500 platform (Illumina, San Diego, CA, USA).
conditions of access: https://publications.europa.eu/resource/authority/access-right/NON_PUBLIC
conditions of access: info:eu-repo/semantics/restrictedAccess
creative work status: completed
  type: DefinedTerm
  in defined term set: http://publications.europa.eu/resource/authority/dataset-status
  term code: COMPLETED
creator: Qirui Zhang
  type: Person
  family name: Zhang
  given name: Qirui
creator: Ton Falqués-Costa
creator: Mattias Pilheden
creator: Helena Sturesson
  type: Person
  family name: Sturesson
  given name: Helena
creator: Anders Castor
  type: Person
  family name: Castor
  given name: Anders
creator: Hanne V. Marquart
  type: Person
  family name: Marquart
  given name: Hanne V.
creator: Birgitte Lausen
  type: Person
  family name: Lausen
  given name: Birgitte
creator: Axel Hyrenius Wittsten
  type: Person
  family name: Wittsten
  given name: Axel Hyrenius
creator: Anna Hagström Andersson
  type: Person
  family name: Hagström Andersson
  given name: Anna
date modified: 2023-11-24
date published: 2023-11-24
funding: The molecular pathogenesis of KMT2A-rearranged leukemia from infancy to adulthood and the clinical impact of tumor heterogeneity
  type: Grant
  funder: Swedish Research Council
keywords: Medical and Health Sciences
  type: DefinedTerm
  term code: 3
keywords: Biological Sciences
  type: DefinedTerm
  term code: 106
keywords: Sequence analysis
publisher: Lund University
version: 0

PropertyValue
property ID: DOI
value: 10.17044/SCILIFELAB.24260710

Ton Falqués-Costa
type: Person
family name: Falqués-Costa
given name: Ton

Mattias Pilheden
type: Person
affiliation: Science for Life Laboratory
family name: Pilheden
given name: Mattias

Science for Life Laboratory
type: Organization

Swedish Research Council
type: Organization

Lund University
type: Organization