Association of estrogen receptor single nucleotide polymorphisms and perinatal depression
type: Dataset
distribution: Landing page for the dataset
description: This data supports findings in a nested study within the population-based prospective Biology, Affect, Stress, Imaging, and Cognition (BASIC) cohort conducted from September 9th 2009 to November 30th 2019 in Uppsala, Sweden (Written, informed consent was obtained from all participants in accordance with the Declaration of Helsinki and the research is approved by the Regional Ethical Review Board in Uppsala [Dnr 2009/171 with amendments]). The main aim of BASIC was to investigate the biopsychosocial processes in perinatal depression (PND) and to identify risk factors to improve early detection. Genetic variations in the estrogen receptor genes (ESR) have been implicated in susceptibility to depression. However, only few studies investigated them in PND and none on its different trajectories (i.e. patterns of time of onset and persistency of depression). Here, we explored the association of single nucleotide polymorphisms (SNPs) of the ESR1 and ESR2 genes with PND among 2,973 women in Sweden. PND was defined using the Edinburgh Postnatal Depression Scale, the Depression Self-Rating Scale, use of selective serotonin reuptake inhibitor, and/or medical records. PND trajectories were identified as follows: controls (no depression at any point in the perinatal period), antepartum (depression during pregnancy and resolved postpartum), postpartum-onset (no depression during pregnancy with onset after delivery), and persistent (depression throughout the perinatal period). DNA was extracted from blood using the silica-based Kleargene XL Nucleic acid extraction kit. Genotyping for ESR1 and ESR2 was performed for 2,915 individuals genotyped using the Illumina Infinium assay and Illumina Global Screening Array – Multi Diseases version 2 (GSA-MDv2) at the SNP&SEQ Technology Platform, SciLifeLab, Uppsala University. One SNP of ESR1 (rs1884051) was performed for 1,425 individuals using the Kbioscience Allele-Specific Polymorphism assay (KASP) based on competitive allele-specific PCR…
modified: 2026-01-16T00:00:00Z
issued: 2026-01-16T00:00:00Z
publisher: Uppsala University
theme: HEAL
access rights: NON PUBLIC
qualified attribution: Attribution
  had role: principalInvestigator
  agent: Alkistis Skalkidou
    type: Agent
    account: https://orcid.org/0000-0002-4935-7532
    type: PrivateIndividual(s)
qualified attribution: Attribution
  had role: principalInvestigator
  agent: Richelle Duque BjÃ¶rvang
    type: Agent
    type: PrivateIndividual(s)
qualified attribution: Attribution
  had role: principalInvestigator
  agent: Lulu Francis Gumbo
    type: Agent
    type: PrivateIndividual(s)
qualified attribution: Attribution
  had role: principalInvestigator
  agent: Anders Årdahl
    type: Agent
    type: PrivateIndividual(s)
qualified attribution: Attribution
  had role: principalInvestigator
  agent: Susanne Lager
    type: Agent
    account: 0000-0003-3556-065X
    type: PrivateIndividual(s)
qualified attribution: Attribution
  had role: principalInvestigator
  agent: Erika Comasco
    type: Agent
    account: https://orcid.org/0000-0002-2174-2068
    type: PrivateIndividual(s)
qualified attribution: Attribution
  had role: principalInvestigator
  agent: Emma Fransson
    type: Agent
    account: https://orcid.org/0000-0001-9010-8522
    type: PrivateIndividual(s)
keyword: Obstetrics and gynaecology
keyword: Psychiatry (incl. psychotherapy)

Landing page for the dataset
type: Distribution
title: Landningssida för datasetet @sv
access URL: Association of estrogen receptor single nucleotide polymorphisms and perinatal depression
availability: stable

Uppsala University
type: Agent
name: Uppsala universitet @sv
type: Academia-ScientificOrganisation
source: https://ror.org/048a87296