<ddi:DDIInstance xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="ddi:instance:3_3 http://ddialliance.org/Specification/DDI-Lifecycle/3.3/XMLSchema/instance.xsd" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:ddi="ddi:instance:3_3" xmlns:r="ddi:reusable:3_3" xmlns:s="ddi:studyunit:3_3" xmlns:d="ddi:datacollection:3_3" xmlns:a="ddi:archive:3_3" xmlns:c="ddi:conceptualcomponent:3_3" xmlns:cm="ddi:comparative:3_3" xmlns:g="ddi:group:3_3" xmlns:l="ddi:logicalproduct:3_3" xmlns:p="ddi:physicaldataproduct:3_3" xmlns:pi="ddi:physicalinstance:3_3" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xhtml="http://www.w3.org/1999/xhtml" xmlns:xml="http://www.w3.org/XML/1998/namespace" isMaintainable="true" scopeOfUniqueness="Agency">
  <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084:0</r:URN>
  <r:Agency>SND</r:Agency>
  <r:ID>doi-10-17044-scilifelab-34767084</r:ID>
  <r:Version>0</r:Version>
  <g:ResourcePackage>
    <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.ResourcePackage:2.0</r:URN>
    <r:OtherMaterialScheme>
      <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.OtherMaterialScheme:2.0</r:URN>
    </r:OtherMaterialScheme>
    <a:OrganizationScheme>
      <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.OrganizationScheme-0:2.0</r:URN>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Individual-0:2.0</r:URN>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Per</a:FirstGiven>
            <a:LastFamily>Nyman</a:LastFamily>
            <a:FullName>
              <r:String>Per Nyman</r:String>
            </a:FullName>
          </a:IndividualName>
          <a:ResearcherID>
            <a:TypeOfID>ORCID</a:TypeOfID>
            <a:ResearcherIdentification>0000-0001-8921-431X</a:ResearcherIdentification>
          </a:ResearcherID>
        </a:IndividualIdentification>
      </a:Individual>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Individual-0:2.0</r:URN>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Iulian Emil</a:FirstGiven>
            <a:LastFamily>Tampu</a:LastFamily>
            <a:FullName>
              <r:String>Iulian Emil Tampu</r:String>
            </a:FullName>
          </a:IndividualName>
          <a:ResearcherID>
            <a:TypeOfID>ORCID</a:TypeOfID>
            <a:ResearcherIdentification>0000-0002-7582-1706</a:ResearcherIdentification>
          </a:ResearcherID>
        </a:IndividualIdentification>
      </a:Individual>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Individual-0:2.0</r:URN>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Alia</a:FirstGiven>
            <a:LastFamily>Shamikh</a:LastFamily>
            <a:FullName>
              <r:String>Alia Shamikh</r:String>
            </a:FullName>
          </a:IndividualName>
          <a:ResearcherID>
            <a:TypeOfID>ORCID</a:TypeOfID>
            <a:ResearcherIdentification>0009-0003-2972-5355</a:ResearcherIdentification>
          </a:ResearcherID>
        </a:IndividualIdentification>
      </a:Individual>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Individual-0:2.0</r:URN>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Gabriela</a:FirstGiven>
            <a:LastFamily>Prochazka</a:LastFamily>
            <a:FullName>
              <r:String>Gabriela Prochazka</r:String>
            </a:FullName>
          </a:IndividualName>
          <a:ResearcherID>
            <a:TypeOfID>ORCID</a:TypeOfID>
            <a:ResearcherIdentification>0009-0009-4534-1101</a:ResearcherIdentification>
          </a:ResearcherID>
        </a:IndividualIdentification>
      </a:Individual>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Individual-0:2.0</r:URN>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Ida</a:FirstGiven>
            <a:LastFamily>Blystad</a:LastFamily>
            <a:FullName>
              <r:String>Ida Blystad</r:String>
            </a:FullName>
          </a:IndividualName>
          <a:ResearcherID>
            <a:TypeOfID>ORCID</a:TypeOfID>
            <a:ResearcherIdentification>0000-0002-8857-5698</a:ResearcherIdentification>
          </a:ResearcherID>
        </a:IndividualIdentification>
      </a:Individual>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Individual-0:2.0</r:URN>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Elisa</a:FirstGiven>
            <a:LastFamily>Basmaci</a:LastFamily>
            <a:FullName>
              <r:String>Elisa Basmaci</r:String>
            </a:FullName>
          </a:IndividualName>
          <a:ResearcherID>
            <a:TypeOfID>ORCID</a:TypeOfID>
            <a:ResearcherIdentification>0000-0002-6123-8261</a:ResearcherIdentification>
          </a:ResearcherID>
        </a:IndividualIdentification>
      </a:Individual>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Individual-0:2.0</r:URN>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Pernilla</a:FirstGiven>
            <a:LastFamily>Augustsson</a:LastFamily>
            <a:FullName>
              <r:String>Pernilla Augustsson</r:String>
            </a:FullName>
          </a:IndividualName>
        </a:IndividualIdentification>
      </a:Individual>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Individual-0:2.0</r:URN>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Arman</a:FirstGiven>
            <a:LastFamily>Ardalan</a:LastFamily>
            <a:FullName>
              <r:String>Arman Ardalan</r:String>
            </a:FullName>
          </a:IndividualName>
          <a:ResearcherID>
            <a:TypeOfID>ORCID</a:TypeOfID>
            <a:ResearcherIdentification>0000-0001-8604-5258</a:ResearcherIdentification>
          </a:ResearcherID>
        </a:IndividualIdentification>
      </a:Individual>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Individual-0:2.0</r:URN>
        <r:UserAttributePair>
          <r:AttributeKey>affiliation</r:AttributeKey>
          <r:AttributeValue>Science for Life Laboratory</r:AttributeValue>
        </r:UserAttributePair>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Praveen Raj</a:FirstGiven>
            <a:LastFamily>Somarajan</a:LastFamily>
            <a:FullName>
              <r:String>Praveen Raj Somarajan</r:String>
            </a:FullName>
          </a:IndividualName>
          <a:ResearcherID>
            <a:TypeOfID>ORCID</a:TypeOfID>
            <a:ResearcherIdentification>0009-0005-5981-2286</a:ResearcherIdentification>
          </a:ResearcherID>
        </a:IndividualIdentification>
      </a:Individual>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Individual-0:2.0</r:URN>
        <r:UserAttributePair>
          <r:AttributeKey>affiliation</r:AttributeKey>
          <r:AttributeValue>Science for Life Laboratory</r:AttributeValue>
        </r:UserAttributePair>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Teresita</a:FirstGiven>
            <a:LastFamily>Díaz de Ståhl</a:LastFamily>
            <a:FullName>
              <r:String>Teresita Díaz de Ståhl</r:String>
            </a:FullName>
          </a:IndividualName>
          <a:ResearcherID>
            <a:TypeOfID>ORCID</a:TypeOfID>
            <a:ResearcherIdentification>0000-0001-5933-6623</a:ResearcherIdentification>
          </a:ResearcherID>
        </a:IndividualIdentification>
      </a:Individual>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Individual-0:2.0</r:URN>
        <r:UserAttributePair>
          <r:AttributeKey>affiliation</r:AttributeKey>
          <r:AttributeValue>Science for Life Laboratory</r:AttributeValue>
        </r:UserAttributePair>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Katarzyna</a:FirstGiven>
            <a:LastFamily>Zielinska-Chomej</a:LastFamily>
            <a:FullName>
              <r:String>Katarzyna Zielinska-Chomej</r:String>
            </a:FullName>
          </a:IndividualName>
          <a:ResearcherID>
            <a:TypeOfID>ORCID</a:TypeOfID>
            <a:ResearcherIdentification>0009-0005-2075-1332</a:ResearcherIdentification>
          </a:ResearcherID>
        </a:IndividualIdentification>
      </a:Individual>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Individual-0:2.0</r:URN>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Duohui</a:FirstGiven>
            <a:LastFamily>Cao</a:LastFamily>
            <a:FullName>
              <r:String>Duohui Cao</r:String>
            </a:FullName>
          </a:IndividualName>
          <a:ResearcherID>
            <a:TypeOfID>ORCID</a:TypeOfID>
            <a:ResearcherIdentification>0009-0002-4115-5781</a:ResearcherIdentification>
          </a:ResearcherID>
        </a:IndividualIdentification>
      </a:Individual>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Individual-0:2.0</r:URN>
        <r:UserAttributePair>
          <r:AttributeKey>affiliation</r:AttributeKey>
          <r:AttributeValue>Science for Life Laboratory</r:AttributeValue>
        </r:UserAttributePair>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Jenny</a:FirstGiven>
            <a:LastFamily>von Salomé</a:LastFamily>
            <a:FullName>
              <r:String>Jenny von Salomé</r:String>
            </a:FullName>
          </a:IndividualName>
          <a:ResearcherID>
            <a:TypeOfID>ORCID</a:TypeOfID>
            <a:ResearcherIdentification>0000-0002-2978-1416</a:ResearcherIdentification>
          </a:ResearcherID>
        </a:IndividualIdentification>
      </a:Individual>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Individual-0:2.0</r:URN>
        <r:UserAttributePair>
          <r:AttributeKey>affiliation</r:AttributeKey>
          <r:AttributeValue>Science for Life Laboratory</r:AttributeValue>
        </r:UserAttributePair>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Gustaf</a:FirstGiven>
            <a:LastFamily>Ljungman</a:LastFamily>
            <a:FullName>
              <r:String>Gustaf Ljungman</r:String>
            </a:FullName>
          </a:IndividualName>
          <a:ResearcherID>
            <a:TypeOfID>ORCID</a:TypeOfID>
            <a:ResearcherIdentification>0000-0002-4949-2494</a:ResearcherIdentification>
          </a:ResearcherID>
        </a:IndividualIdentification>
      </a:Individual>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Individual-0:2.0</r:URN>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Peter</a:FirstGiven>
            <a:LastFamily>Lundberg</a:LastFamily>
            <a:FullName>
              <r:String>Peter Lundberg</r:String>
            </a:FullName>
          </a:IndividualName>
          <a:ResearcherID>
            <a:TypeOfID>ORCID</a:TypeOfID>
            <a:ResearcherIdentification>0000-0001-8661-2232</a:ResearcherIdentification>
          </a:ResearcherID>
        </a:IndividualIdentification>
      </a:Individual>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Individual-0:2.0</r:URN>
        <r:UserAttributePair>
          <r:AttributeKey>affiliation</r:AttributeKey>
          <r:AttributeValue>Science for Life Laboratory</r:AttributeValue>
        </r:UserAttributePair>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Johanna</a:FirstGiven>
            <a:LastFamily>Sandgren</a:LastFamily>
            <a:FullName>
              <r:String>Johanna Sandgren</r:String>
            </a:FullName>
          </a:IndividualName>
          <a:ResearcherID>
            <a:TypeOfID>ORCID</a:TypeOfID>
            <a:ResearcherIdentification>0000-0001-6776-2649</a:ResearcherIdentification>
          </a:ResearcherID>
        </a:IndividualIdentification>
      </a:Individual>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Individual-0:2.0</r:URN>
        <r:UserAttributePair>
          <r:AttributeKey>affiliation</r:AttributeKey>
          <r:AttributeValue>Science for Life Laboratory</r:AttributeValue>
        </r:UserAttributePair>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Neda</a:FirstGiven>
            <a:LastFamily>Haj Hosseini</a:LastFamily>
            <a:FullName>
              <r:String>Neda Haj Hosseini</r:String>
            </a:FullName>
          </a:IndividualName>
          <a:ResearcherID>
            <a:TypeOfID>ORCID</a:TypeOfID>
            <a:ResearcherIdentification>0000-0002-0555-8877</a:ResearcherIdentification>
          </a:ResearcherID>
        </a:IndividualIdentification>
      </a:Individual>
    </a:OrganizationScheme>
  </g:ResourcePackage>
  <s:StudyUnit>
    <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.StudyUnit:2.0</r:URN>
    <r:UserID typeOfUserID="datasetIdentifier">doi-10-17044-scilifelab-34767084</r:UserID>
    <r:Citation>
      <r:Title>
        <r:String xml:lang="en">A Multicenter Swedish Histopathology Image Dataset of Pediatric Central Nervous System Tumors</r:String>
      </r:Title>
      <r:Creator>
        <r:CreatorReference>
          <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Individual-0:2.0</r:URN>
          <r:TypeOfObject>Individual</r:TypeOfObject>
        </r:CreatorReference>
      </r:Creator>
      <r:Publisher>
        <r:PublisherName>
          <r:String xml:lang="sv">SciLifeLab</r:String>
          <r:String xml:lang="en">SciLifeLab</r:String>
        </r:PublisherName>
      </r:Publisher>
      <r:Publisher>
        <r:PublisherName>
          <r:String xml:lang="sv">SciLifeLab</r:String>
          <r:String xml:lang="en">SciLifeLab</r:String>
        </r:PublisherName>
      </r:Publisher>
      <r:PublicationDate>
        <r:SimpleDate>2026-10-27</r:SimpleDate>
      </r:PublicationDate>
      <r:InternationalIdentifier>
        <r:IdentifierContent>10.17044/SCILIFELAB.34767084</r:IdentifierContent>
        <r:ManagingAgency controlledVocabularyAgencyName="DOI">DOI</r:ManagingAgency>
      </r:InternationalIdentifier>
    </r:Citation>
    <r:Abstract>
      <r:Content xml:lang="en">This record describes version 1.0 of a multicenter dataset of digitized hematoxylin and eosin-stained histopathology slides of pediatric central nervous system (CNS) tumors, collected through the Swedish Childhood Tumor Biobank (BTB) from six Swedish university hospitals between 2013 and 2023. The data are pseudonymised personal data under the GDPR and are therefore not deposited here. Access is provided by BTB mentioned at: www.barntumorbanken.se

CONTENT
The dataset contains 1366 whole slide images (WSIs) from 535 cases in 516 subjects aged 0–18 years at primary diagnosis. Of these, 499 subjects have a tumor diagnosis covering 10 categories, 26 families and 39 types according to the WHO 2021 classification of CNS tumors. 17 subjects have non-tumor diagnoses.

FILES
One file per WSI, named [WSI ID].ndpi or [WSI ID].svs, organised in one folder per centre: Stockholm (226 WSIs), Gothenburg (289), Lund (126), Linkoping (165), Umea (179), Uppsala (381). The dataset also contains clinical_information.csv (one row per WSI).

CLINICAL VARIABLES
wsi_id, subject_id, recurrence, center, sex, age at diagnosis (months), WHO 2021 category, family, type and subtype, original diagnosis and tumor location.

SOFTWARE
NDPI and SVS files can be opened with QuPath, NDP.view2, Aperio ImageScope or the OpenSlide library.

ACCESS
Access is granted for research on childhood cancer to projects with ethical approval, after review by BTB and Stockholm Medical Biobank, and a signed data transfer agreement. Approved researchers receive the files through a secure download link.


The procedure for the researchers:

- Present a valid and relevant ethical approval that concerns pediatric cancer research and includes an appropriate data management plan for processing and protecting personal data
- Send an application for data acquisition to BTB by filling out the forms: https://www.barntumorbanken.se/blanketter/ 
- Send in the data transfer agreement available in the link below: https://www.barntumorbanken.se/s/BTB-Data-Transfer-Agreement_sep2023.docx
- After approval, the user can make an account at https://nextcloud.com/sign-up/ and get access to data under controlled-access via the secure infrastructure.</r:Content>
    </r:Abstract>
    <r:Coverage>
      <r:TopicalCoverage>
        <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.TopicalCoverage:2.0</r:URN>
        <r:Subject xml:lang="en" controlledVocabularyID="3" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Medical and Health Sciences</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="3" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Medicin och hälsovetenskap</r:Subject>
        <r:Subject xml:lang="en" controlledVocabularyID="30203" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Cancer and Oncology</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="30203" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Cancer och onkologi</r:Subject>
      </r:TopicalCoverage>
      <r:SpatialCoverage />
    </r:Coverage>
    <a:Archive>
      <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Archive:2.0</r:URN>
      <a:ArchiveSpecific>
        <a:Item>
          <a:Access>
            <r:URN>urn:ddi:se.researchdata:doi-10-17044-scilifelab-34767084.Archive-ArchiveSpecificType-AccessType:2.0</r:URN>
            <a:TypeOfAccess controlledVocabularyName="info:eu-repo-Access-Terms vocabulary">restrictedAccess</a:TypeOfAccess>
          </a:Access>
          <a:DataFileQuantity>0</a:DataFileQuantity>
        </a:Item>
      </a:ArchiveSpecific>
    </a:Archive>
  </s:StudyUnit>
</ddi:DDIInstance>