BAMSE projektet 12 år The BAMSE project 12 years ext0037-6-1 Swedish National Data Service Svensk nationell datatjänst BAMSE projektet 12 år The BAMSE project 12 years ext0037-6-1 Wickman, Magnus Wickman, Magnus Pershagen, Göran Pershagen, Göran Kull, Inger Kull, Inger Melén, Erik Melén, Erik Bergström, Anna Bergström, Anna Swedish National Data Service Svensk nationell datatjänst Blood Pressure Blodtryck Blood Specimen Collection Blodprovstagning Life Style Livsstil Longitudinal Studies Longitudinella studier Prospective Studies Prospektiva studier Socioeconomic Factors Socioekonomiska faktorer Allergens Allergener Allergy and Immunology Allergi och immunologi Respiratory Function Tests Respiratoriska funktionstester Respiratory Sounds Andningsljud Asthma Astma Child Barn Eczema Eksem Genetics Genetik Body Height Kroppslängd Body Weight Kroppsvikt Patch Tests Lapptester Food Hypersensitivity Livsmedelsöverkänslighet Air Pollution Luftförorening Air Pollution, Indoor Luftförorening, inomhus Lung Diseases Lungsjukdomar Environmental Exposure Miljöexponering Tobacco Smoke Pollution Tobaksröksförorening Pollen Pollen Rhinitis Snuva Pets Sällskapsdjur Heredity Ärftlighet Hypersensitivity Överkänslighet HEALTH HÄLSA Both heredity and environmental factors influence childrens' risk for developing respiratory and allergy related diseases, but how these factors influence the age of onset and the prognosis is little studied. It is also unknown which factors determine whether these diseases disappear in the childhood years, if they remain mild or worsen. An integrated database where lifestyle and allergic diseases are studied from birth through adolescence is lacking both nationally and internationally. From 1994 to 1996 a little more than 4,000 children were borne in certain pre-selected areas of Stockholm County. They have been followed repeatedly with questionnaires and surveys (at 0, 1, 2, 4, 8 and 12 years of age) as part of the so-called BAMSE project. In the last follow-up the response rate was 82% compared to baseline. Now, when the youths have reached the age 16 years, a resource-intensive data collection has started, including studies of weight, height, blood pressure, lung function tests, patch tests and blood tests (complete blood count, allergy levels and genetics, and nasal lavage). A larger database of more than 6000 variables containing all the information gathered has gradually been built up. Extensive national and international research cooperation around environmental factors and genetics in relation to the development of pulmonary and allergic diseases has been established within the project. By using the collected data material the development of allergic diseases has been described as well as risk factors for allergic diseases and the impact on quality of life of such diseases. More than 70 scientific articles have been published and 16 doctoral dissertations and licentiate thesis has been presented. Extensive efforts to develop the database are ongoing through entering and evaluating the collected data, work with descriptions of individual and composite variables that are used by the various research groups, and through developing the epidemiological and statistical analysis techniques. With help from epidemiology assistants and statisticians a high quality of the data used by different research groups is ensured. New opportunities for research: More than 30 senior researchers at KI, as well as nationally and internationally outside KI works within the project. The project is part of a European cooperation in which a significant number of cohorts are included in order to obtain sufficient statistical power. Data on more than 30 000 children are included in the European database where BAMSE is contributing with data on 4000 children. Several areas can be researched, but the main emphasis will be on respiratory and allergic diseases, environmental factors and genetics. Great efforts are made for the database to become known and available to researchers. The BAMSE database structure is already available online at three different sites. Importance of study: With its population-based recruitment, repeated follow-ups with the collection of biological material throughout childhood and into adolescence, little loss, more than 6000 variables, a European cooperation and the development of a common database of more than 30 000 children, there is an excellent opportunity to cutting-edge research aimed at preventing pulmonary and allergic diseases and to reduce the burden on those already affected. Purpose: To better understand how factors such as environment and lifestyle affect the risk of allergic disease in childhood. Questionnaire completed by both parents (732 vaiables) and children (199 variables) Både ärftliga och miljörelaterade faktorer påverkar risken att barn insjuknar i lung- och allergirelaterade sjukdomar, men hur dessa faktorer påverkar debutålder och prognos är föga studerat. Likaså är det okänt vilka faktorer som avgör om dessa sjukdomar går tillbaka under barnaåren, om de förblir av lindrig art eller förvärras. En sammanhållen databas där livsstil och allergisjukdom studeras från födseln till och med tonåren saknas både nationellt och internationellt. Infrastrukturens användning: från 1994 till 1996 föddes drygt 4000 barn i vissa på förhand utvalda områden i Stockholms län. Dessa har följts med upprepade frågeformulär och undersökningar inom ramen för det s.k. BAMSE-projektet (0, 1, 2, 4, 8 och 12 år). Vid den senaste uppföljningen var svarsfrekvensen 82% jämfört med studiestart. Nu när ungdomarna är 16 år pågår en mycket resurskrävande datainsamling inkluderande en rad undersökningar: vikt, längd, blodtryck, olika lungfunktionstester, lapptest samt blodprov (blodstatus, allerginivåer och genetik och nässköljning). En större databas på mer än 6000 variabler innehållande all insamlad information har succesivt byggts upp. Ett omfattande nationellt och internationellt forskningssamarbete är etablerat kring miljö och genetik i relation till utveckling av lung- och allergisjukdomar inom ramen för projektet. Med data från det insamlade materialet har utvecklingen av allergisjukdomar beskrivits liksom riskfaktorer för allergisjukdomar samt konsekvenser på livskvalitén av sådana sjukdomar. Mer än 70 vetenskapliga artiklar har publicerats, 16 doktorsavhandlingar och en licentiatavhandling har lagts fram. Fortlöpande sker ett omfattande arbete med att utveckla databasen genom att lägga in och utvärdera insamlade data, arbeta med beskrivningar av enskilda och sammansatta variabler som används av de olika forskargrupperna, samt utveckla den epidemiologiskt/statistiska analystekniken. Med hjälp av epidemiologassistenter och statistiker säkerställs en hög kvalitet i de datasett som används av olika forskargrupper. Nya möjligheter till forskning: Mer än 30 seniora forskare inom KI, nationellt utanför KI samt internationellt samarbetar med projektet. Projektet ingår i europasamarbete där ett flertal kohorter ingår för att erhålla tillräcklig statistisk teststyrka. Data på mer än 30 000 barn finns i den gemensamma europeiska databasen där BAMSE således bidrar med data på 4000 barn. Ett flertal områden kan beforskas, men huvudvikt kommer att ligga på lung- och allergisjukdomar, miljö och genetik. Stora ansträngningar görs för att databasen ska bli allmänt känd och tillgänglig för forskare. BAMSE-databasens struktur finns bl.a. tillgänglig via internet på tre sajter. Betydelse: Genom sin populationsbaserade rekrytering, upprepade uppföljningar med insamlande av biologiskt material under hela barndomen och upp i tonåren, litet bortfall, mer än 6 000 variabler, europeiskt samarbete och uppbyggnad av gemensam databas på mer än 30 000 barn, så föreligger det utmärkta möjligheter till världsledande forskning med syfte att förebygga lung- och allergisjukdomar samt att minska bördan för redan drabbade. Syfte: Att bättre förstå hur faktorer som miljö och livsstil påverkar risken för allergisjukdom under uppväxten. Enkät besvarad av både föräldrar (731 variabler) och barn (199 variabler) 2002 2004 Sweden Sverige IndividualIndividual IndividIndivid Children and parents from selected areas in Stockholm County Barn och föräldrar från utvalda områden i Stockholms län Numeric Longitudinal: Cohort/Event-basedLongitudinal: Cohort/Event-based Longitudinell: Kohort/HändelsebaseradLongitudinell: Kohort/Händelsebaserad All parents to children born in Järfälla, Solna, Sundbyberg, Vasastan and Norrmalm from Februari 1994 to November 1996 were asked by their pediatric clinic nurse to participate in the study.All parents to children born in Järfälla, Solna, Sundbyberg, Vasastan and Norrmalm from Februari 1994 to November 1996 were asked by their pediatric clinic nurse to participate in the study. Samtliga föräldrar till barn som föddes i Järfälla, Solna, Sundbyberg samt Vasastan och Norrmalm från februari 1994 till november 1996 tillfrågades av sin BVC-sköterska om att delta i studien.Samtliga föräldrar till barn som föddes i Järfälla, Solna, Sundbyberg samt Vasastan och Norrmalm från februari 1994 till november 1996 tillfrågades av sin BVC-sköterska om att delta i studien. Physical measurements and testsPhysical measurements and tests Fysiska mätningar och testerFysiska mätningar och tester Access to data through an external actor. Access to data is restricted. Åtkomst till data via extern aktör. Tillgång till data är begränsad. restrictedAccess Kull, Inger. Infant feeding and allergy in children. Doktorsavhandling, Karolinska institutet, Stockholm 2005 Kull, Inger. Infant feeding and allergy in children. Doktorsavhandling, Karolinska institutet, Stockholm 2005 Wickman M, Melen E, Berglind N, Lennart Nordvall S, Almqvist C, Kull I, Svartengren M, Pershagen G. Strategies for preventing wheezing and asthma in small children. Allergy 2003; 58(8): 742-747. Wickman M, Melen E, Berglind N, Lennart Nordvall S, Almqvist C, Kull I, Svartengren M, Pershagen G. Strategies for preventing wheezing and asthma in small children. Allergy 2003; 58(8): 742-747. Ballardini N., Kull I., Lind T., Hallner E., Almqvist C., Ostblom E., Melén E., Pershagen G., Lilja G., Bergström A., Wickman M. Development and comorbidity of eczema, asthma and rhinitis to age 12 - data from the BAMSE birth cohort. Allergy 2012 Feb 16. Ballardini N., Kull I., Lind T., Hallner E., Almqvist C., Ostblom E., Melén E., Pershagen G., Lilja G., Bergström A., Wickman M. Development and comorbidity of eczema, asthma and rhinitis to age 12 - data from the BAMSE birth cohort. Allergy 2012 Feb 16. Westman M., Stjärne P., Asarnoj A., Kull I., van Hage M., Wickman M., Toskala E. Natural course and comorbidities of allergic and nonallergic rhinitis in children. Journal of Allergy and Clinical Immunology 2012 Feb;129(2):403-8. Westman M., Stjärne P., Asarnoj A., Kull I., van Hage M., Wickman M., Toskala E. Natural course and comorbidities of allergic and nonallergic rhinitis in children. Journal of Allergy and Clinical Immunology 2012 Feb;129(2):403-8. Vrijheid M., Casas M., Bergström A., Carmichael A., Cordier S., Eggesbø M., Eller E., Fantini MP., Fernández MF., Fernández-Somoano A., Gehring U., Grazuleviciene R., Hohmann C., Karvonen AM., Keil T., Kogevinas M., Koppen G., Krämer U., Kuehni CE., Magnus P., Majewska R., Andersen AM., Patelarou E., Petersen MS., Pierik FH., Polanska K., Porta D., Richiardi L., Santos AC., Slama R., Sram RJ., Thijs C., Tischer C., Toft G., Trnovec T., Vandentorren S., Vrijkotte TG., Wilhelm M., Wright J., Nieuw Vrijheid M., Casas M., Bergström A., Carmichael A., Cordier S., Eggesbø M., Eller E., Fantini MP., Fernández MF., Fernández-Somoano A., Gehring U., Grazuleviciene R., Hohmann C., Karvonen AM., Keil T., Kogevinas M., Koppen G., Krämer U., Kuehni CE., Magnus P., Majewska R., Andersen AM., Patelarou E., Petersen MS., Pierik FH., Polanska K., Porta D., Richiardi L., Santos AC., Slama R., Sram RJ., Thijs C., Tischer C., Toft G., Trnovec T., Vandentorren S., Vrijkotte TG., Wilhelm M., Wright J., Nieuw Gruzieva O., Bellander T., Eneroth K., Kull I., Melén E., Nordling E., van Hage M., Wickman M., Moskalenko V., Hulchiy O., Pershagen G. Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of life. Journal of Allergy and Clinical Immunology 2012 Jan; 129(1): 240-6 Gruzieva O., Bellander T., Eneroth K., Kull I., Melén E., Nordling E., van Hage M., Wickman M., Moskalenko V., Hulchiy O., Pershagen G. Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of life. Journal of Allergy and Clinical Immunology 2012 Jan; 129(1): 240-6 Magnusson JÖ., Kull I., Mai XM., Wickman M., Bergström A. Early childhood overweight and asthma and allergic sensitization at 8 years of age. Pediatrics. 2012 Jan;129(1):70-6. Magnusson JÖ., Kull I., Mai XM., Wickman M., Bergström A. Early childhood overweight and asthma and allergic sensitization at 8 years of age. Pediatrics. 2012 Jan;129(1):70-6. Panasevich S., Lindgren C., Kere J., Wickman M., Pershagen G., Nyberg F., Melén E. Interaction between early maternal smoking and variants in TNF and GSTP1 in childhood wheezing. Clin Exp Allergy 2010 Mar;40(3):458-67. Panasevich S., Lindgren C., Kere J., Wickman M., Pershagen G., Nyberg F., Melén E. Interaction between early maternal smoking and variants in TNF and GSTP1 in childhood wheezing. Clin Exp Allergy 2010 Mar;40(3):458-67. Neumann A., Söderhäll C., Fölster-Holst R., Baurecht H., Harde V., Müller-Wehling K., Rodríguez E., Ruether A., Franke A., Wagenpfeil S., Novak N., Mempel M., Kalali BN., Allgaeuer M., Koch J., Gerhard M., Melén E., Wahlgren CF., Kull I., Stahl C., Pershagen G., Lauener R., Riedler J., Doekes G., Scheynius A., Illig T., von Mutius E., Schreiber S., Kere J., Kabesch M., Weidinger S. A comprahensive analysis of the COL29A1 gene does not support a role in eczema. Journal of Allergy and Clinical Imm Neumann A., Söderhäll C., Fölster-Holst R., Baurecht H., Harde V., Müller-Wehling K., Rodríguez E., Ruether A., Franke A., Wagenpfeil S., Novak N., Mempel M., Kalali BN., Allgaeuer M., Koch J., Gerhard M., Melén E., Wahlgren CF., Kull I., Stahl C., Pershagen G., Lauener R., Riedler J., Doekes G., Scheynius A., Illig T., von Mutius E., Schreiber S., Kere J., Kabesch M., Weidinger S. A comprahensive analysis of the COL29A1 gene does not support a role in eczema. Journal of Allergy and Clinical Imm Rosenlund H., Kull I., Pershagen G., Wolk A., Wickman M., Bergström A. Fruit and vegetable consumption in relation to allergy: disease-related modification of consumption? Journal of Allergy and Clinical Immunology 2011 May;127(5):1219-25. Rosenlund H., Kull I., Pershagen G., Wolk A., Wickman M., Bergström A. Fruit and vegetable consumption in relation to allergy: disease-related modification of consumption? Journal of Allergy and Clinical Immunology 2011 May;127(5):1219-25. Nydert P., Kimland E., Kull I., Lindemalm S. Over-the-counter drug use - estimations within the Swedish paediatric population. European Journal of Pediatrics 2011 May;170(5):583-8 Nydert P., Kimland E., Kull I., Lindemalm S. Over-the-counter drug use - estimations within the Swedish paediatric population. European Journal of Pediatrics 2011 May;170(5):583-8 Brew BK., Kull I., Garden F., Almqvist C., Bergström A., Lind T., Webb K., Wickman M., Marks GB. Breastfeeding, asthma and allergy: a tale of two cities Pediatric Allergy and Immunology 2012 Feb;23(1):75-82 Brew BK., Kull I., Garden F., Almqvist C., Bergström A., Lind T., Webb K., Wickman M., Marks GB. Breastfeeding, asthma and allergy: a tale of two cities Pediatric Allergy and Immunology 2012 Feb;23(1):75-82 Bunyavanich S., Melen E., Wilk JB., Granada M., Soto-Quiros ME., Avila L., Lasky-Su J., Hunninghake GM., Wickman M., Pershagen G., O'Connor GT., Weiss ST., Celedón JC. Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma. Clinical and Molecular Allergy 2011 Jan 18;9:1 Bunyavanich S., Melen E., Wilk JB., Granada M., Soto-Quiros ME., Avila L., Lasky-Su J., Hunninghake GM., Wickman M., Pershagen G., O'Connor GT., Weiss ST., Celedón JC. Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma. Clinical and Molecular Allergy 2011 Jan 18;9:1 Asarnoj A., Movérare R, Ostblom E., Poorafshar M., Lilja G., Hedlin G., van Hage M., Ahlstedt S., Wickman M. IgE to peanut allergen components: relation to peanut symptoms and pollen sensitization in 8-year-olds. Allergy 2010 Sep;65(9):1189-95. Asarnoj A., Movérare R, Ostblom E., Poorafshar M., Lilja G., Hedlin G., van Hage M., Ahlstedt S., Wickman M. IgE to peanut allergen components: relation to peanut symptoms and pollen sensitization in 8-year-olds. Allergy 2010 Sep;65(9):1189-95. Asarnoj A., Östblom E., Ahlstedt S., Hedlin G., Lilja G., van Hage M., Wickman M. Reported symptoms to peanut between 4 and 8 years among children sensitized to peanut and birch pollen - results from the BAMSE birth cohort. Allergy 2010; 65: 213-219 Asarnoj A., Östblom E., Ahlstedt S., Hedlin G., Lilja G., van Hage M., Wickman M. Reported symptoms to peanut between 4 and 8 years among children sensitized to peanut and birch pollen - results from the BAMSE birth cohort. Allergy 2010; 65: 213-219 Saarne T., Grönlund H., Kull I., Almqvist C., Wickman M., van Hage M. Cat sensitization identified by recombinant Fel d 1 several years before symptoms - results from the bamse cohort. Pediatric Allergy and Immunology 2010; 21: 277-283 Saarne T., Grönlund H., Kull I., Almqvist C., Wickman M., van Hage M. Cat sensitization identified by recombinant Fel d 1 several years before symptoms - results from the bamse cohort. Pediatric Allergy and Immunology 2010; 21: 277-283 Hallberg J., Anderson M., Wickman M., Svartengren M. Factors in Infancy and Childhood Related to Reduced Lung Function in Asthmatic Children: A Birth Cohort Study (BAMSE). Pediatric Pulmonology 2010; 45: 341-348 Hallberg J., Anderson M., Wickman M., Svartengren M. Factors in Infancy and Childhood Related to Reduced Lung Function in Asthmatic Children: A Birth Cohort Study (BAMSE). Pediatric Pulmonology 2010; 45: 341-348 Donner J., Haapakoski R., Ezer S., Melén E., Pirkola S., Gratacòs M., Zucchelli M., Anedda F., Johansson L. E., Söderhäll C., Orsmark-Pietras C., Suvisaari J., Martín-Santos R., Torrens M., Silander K., Terwilliger J. D., Wickman M., Pershagen G., Lönnqvist J., Peltonen L., Estivill X., D'Amato M., Kere J., Alenius H., Hovatta I. Assessment of the Neuropeptide S System in Anxiety Disorders. Biological Psychiatry 2010;68:474-483 Donner J., Haapakoski R., Ezer S., Melén E., Pirkola S., Gratacòs M., Zucchelli M., Anedda F., Johansson L. E., Söderhäll C., Orsmark-Pietras C., Suvisaari J., Martín-Santos R., Torrens M., Silander K., Terwilliger J. D., Wickman M., Pershagen G., Lönnqvist J., Peltonen L., Estivill X., D'Amato M., Kere J., Alenius H., Hovatta I. Assessment of the Neuropeptide S System in Anxiety Disorders. Biological Psychiatry 2010;68:474-483 Böhme M., Kull I., Bergström A., Wickman M., Nordvall L., Pershagen G., Wahlgren CF. Parental smoking increases the risk for eczema with sensitization in 4-year-old children. Journal of Allergy and Clinical Immunology 2010 Apr;125(4):941-3. Böhme M., Kull I., Bergström A., Wickman M., Nordvall L., Pershagen G., Wahlgren CF. Parental smoking increases the risk for eczema with sensitization in 4-year-old children. Journal of Allergy and Clinical Immunology 2010 Apr;125(4):941-3. Marmsjö K., Rosenlund H., Kull I., Håkansson N., Wickman M., Pershagen G., Bergström A. Use of multivitamin supplements in relation to allergic disease in 8-y-old children. The American Journal of Clinical Nutrition 2009 Dec;90(6):1693-8. Marmsjö K., Rosenlund H., Kull I., Håkansson N., Wickman M., Pershagen G., Bergström A. Use of multivitamin supplements in relation to allergic disease in 8-y-old children. The American Journal of Clinical Nutrition 2009 Dec;90(6):1693-8. Hunninghake GM., Cho MH., Tesfaigzi Y., Soto-Quiros ME., Avila L., Lasky-Su J., Stidley C., Melén E., Söderhäll C., Hallberg J., Kull I., Kere J., Svartengren M., Pershagen G., Wickman M., Lange C., Demeo DL., Hersh CP., Klanderman BJ., Raby BA., Sparrow D., Shapiro SD., Silverman EK., Litonjua AA., Weiss ST., Celedón JC. MMP12, lung function, and COPD in high-risk populations. The New England Journal of Medicine 2009 Dec 31;361(27):2599-608 Hunninghake GM., Cho MH., Tesfaigzi Y., Soto-Quiros ME., Avila L., Lasky-Su J., Stidley C., Melén E., Söderhäll C., Hallberg J., Kull I., Kere J., Svartengren M., Pershagen G., Wickman M., Lange C., Demeo DL., Hersh CP., Klanderman BJ., Raby BA., Sparrow D., Shapiro SD., Silverman EK., Litonjua AA., Weiss ST., Celedón JC. MMP12, lung function, and COPD in high-risk populations. The New England Journal of Medicine 2009 Dec 31;361(27):2599-608 Janzi M., Kull I., Sjöberg R., Wan J., Melén E., Bayat N., Östblom E., Pan-Hammarström Q., Nilsson P., Hammarström L. Selective IgA deficiency in early life: Association to infections and allergic diseases during childhood. Clinical Immunology 2009; 133: 78-85 Janzi M., Kull I., Sjöberg R., Wan J., Melén E., Bayat N., Östblom E., Pan-Hammarström Q., Nilsson P., Hammarström L. Selective IgA deficiency in early life: Association to infections and allergic diseases during childhood. Clinical Immunology 2009; 133: 78-85 Panasevich S., Leander K., Rosenlund M., Ljungman P., Bellander T., de Faire U., Pershagen G., Nyberg F. Associations of long- and short-term air pollution exposure with markers of inflammation and coagulation in a population sample. Occup Environ Med. 2009 Nov;66(11):747-53. Panasevich S., Leander K., Rosenlund M., Ljungman P., Bellander T., de Faire U., Pershagen G., Nyberg F. Associations of long- and short-term air pollution exposure with markers of inflammation and coagulation in a population sample. Occup Environ Med. 2009 Nov;66(11):747-53. Melén E., Nyberg F., Lindgren CM., Berglind N., Zucchelli M., Nordling E., Hallberg J., Svartengren M., Morgenstern R., Kere J., Bellander T., Wickman M., Pershagen G. Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease. Environmental Health Perspectives 2008 Aug;116(8):1077-84. Melén E., Nyberg F., Lindgren CM., Berglind N., Zucchelli M., Nordling E., Hallberg J., Svartengren M., Morgenstern R., Kere J., Bellander T., Wickman M., Pershagen G. Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease. Environmental Health Perspectives 2008 Aug;116(8):1077-84. Nordling E., Berglind N., Melén E., Emenius G., Hallberg J., Nyberg F., Pershagen G., Svartengren M., Wickman M., Bellander T. Traffic-related air pollution and childhood respiratory symptoms, function and allergies. Epidemiology 2008 May;19(3):401-8 Nordling E., Berglind N., Melén E., Emenius G., Hallberg J., Nyberg F., Pershagen G., Svartengren M., Wickman M., Bellander T. Traffic-related air pollution and childhood respiratory symptoms, function and allergies. Epidemiology 2008 May;19(3):401-8 Asarnoj A., Östblom E., Kull I., Lilja G., Pershagen G., Hedlin G., van Hage M., Wickman M. Sensitization to inhalant allergens between 4 and 8 years of age is a dynamic process: results from the BAMSE birth cohort. Clinical and Experimental Allergy 2008; 38: 1507-1513 Asarnoj A., Östblom E., Kull I., Lilja G., Pershagen G., Hedlin G., van Hage M., Wickman M. Sensitization to inhalant allergens between 4 and 8 years of age is a dynamic process: results from the BAMSE birth cohort. Clinical and Experimental Allergy 2008; 38: 1507-1513 Mai X.-M., Neuman Å., Östblom E., Pershagen G., Nordvall L., Almqvist C., van Hage M., Wickman M. Symptoms to pollen and fruits early in life and allergic disease at 4 years of age. Allergy 2008; 63: 1499-1504 Mai X.-M., Neuman Å., Östblom E., Pershagen G., Nordvall L., Almqvist C., van Hage M., Wickman M. Symptoms to pollen and fruits early in life and allergic disease at 4 years of age. Allergy 2008; 63: 1499-1504 Lannerö E., Wickman M., van Hage M., Bergström A., Pershagen G., Nordvall.L. Exposure to environmental tobacco smoke and sensitisation in children. Thorax 2008; 63: 172-176 Lannerö E., Wickman M., van Hage M., Bergström A., Pershagen G., Nordvall.L. Exposure to environmental tobacco smoke and sensitisation in children. Thorax 2008; 63: 172-176 Östblom E., Egmar A.-C., Gardulf A., Lilja G., Wickman M. The impact of food hypersensitivity reported in 9-year-old children by their parents on health-related quality of life. Allergy 2008: 63: 211-218 Östblom E., Egmar A.-C., Gardulf A., Lilja G., Wickman M. The impact of food hypersensitivity reported in 9-year-old children by their parents on health-related quality of life. Allergy 2008: 63: 211-218 Mai X-M., Almqvist C., Nilsson L., Wickman M. Birth anthropometric measures, body mass index and allergic diseases in a birth cohort study (BAMSE). Archives of Disease in Childhood 2007; 92: 881-886 Mai X-M., Almqvist C., Nilsson L., Wickman M. Birth anthropometric measures, body mass index and allergic diseases in a birth cohort study (BAMSE). Archives of Disease in Childhood 2007; 92: 881-886 Kull I., Bergström A., Melén E., Lilja G., van Hage M., Pershagen G., Wickman M. Early-life supplementation of vitamins A and D, in water-soluble form or in peanut oil, and allergic diseases during childhood. Journal of Allergy and Clinical Immunology 2006 Dec;118(6):1299-304. Kull I., Bergström A., Melén E., Lilja G., van Hage M., Pershagen G., Wickman M. Early-life supplementation of vitamins A and D, in water-soluble form or in peanut oil, and allergic diseases during childhood. Journal of Allergy and Clinical Immunology 2006 Dec;118(6):1299-304. Lannerö E., Pershagen G., Wickman M., Nordvall L. Maternal smoking during pregnancy increases the risk of recurrent wheezing during the first years of life (BAMSE). Respiratory Research -On line. 2006; 7:3 Lannerö E., Pershagen G., Wickman M., Nordvall L. Maternal smoking during pregnancy increases the risk of recurrent wheezing during the first years of life (BAMSE). Respiratory Research -On line. 2006; 7:3 Hallberg J., Anderson M., Wickman M., Svartengren M. Sex influences on lung function and medication in childhood asthma. Acta Pædiatrica, 2006; 95: 1191-1196 Hallberg J., Anderson M., Wickman M., Svartengren M. Sex influences on lung function and medication in childhood asthma. Acta Pædiatrica, 2006; 95: 1191-1196 Ghunaim N., Wickman M., Almqvist C., Söderström L., Ahlstedt S., van Hage M. Sensitization to different pollens and allergic disease in 4-year-old Swedish children. Clinical and Experimental Allergy 2006; 36: 722-727 Ghunaim N., Wickman M., Almqvist C., Söderström L., Ahlstedt S., van Hage M. 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M., Riedler J., Scheynius A., van Hage-Hamsten M., Kere J., Pershagen G., Wickman M., Nyberg F., and the PARSIFAL Genetics Study Group. Haplotypes of G Protein-coupled Receptor 154 Are Associated with Childhood Allergy and Asthma. American Journal of Respiratory and Critical Care Medicine 2005; 171 Sidorchuk A., Wickman M., Pershagen G., Lagarde F., Linde A. Cytomegalovirus infection and development of allergic diseases in early childhood: interaction with EBV infection? Journal of Allergy and Clinical Immunology 2004 Dec;114(6):1434-40 Sidorchuk A., Wickman M., Pershagen G., Lagarde F., Linde A. Cytomegalovirus infection and development of allergic diseases in early childhood: interaction with EBV infection? Journal of Allergy and Clinical Immunology 2004 Dec;114(6):1434-40 Melén E, Kere J, Pershagen G, Svartengren M, Wickman M. Influence of male sex and parental allergic disease on childhood wheezing: role of interactions. Clinical and Experimental Allergy 2004 Jun;34(6):839-44. 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Epstein-Barr virus infection is not associated with development of allergy in children. The Pediatric Infectious Disease Journal 2003 Jul;22(7):642-7 Sidorchuk A., Lagarde F., Pershagen G., Wickman M., Linde A. Epstein-Barr virus infection is not associated with development of allergy in children. The Pediatric Infectious Disease Journal 2003 Jul;22(7):642-7 Wickman M, Ahlstedt S, Lilja G, van Hage-Hamsten M. Quantification of IgE antibodies simplifies the classification of allergic diseases in 4-year-old children. A report from the prospective birth cohort study - BAMSE. Pediatric Allergy and Immunology 2003; 14: 441-447. Wickman M, Ahlstedt S, Lilja G, van Hage-Hamsten M. Quantification of IgE antibodies simplifies the classification of allergic diseases in 4-year-old children. A report from the prospective birth cohort study - BAMSE. Pediatric Allergy and Immunology 2003; 14: 441-447. 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