Breast Cancer-metastases study
type: Dataset
description: The participants in this cohort are individuals with breast cancer and metastatic disease coming to the Department of Oncology in Lund for treatment since 2003. The data collection in the study is still ongoing. From all individuals, there is information about the status of the primary tumor, metastatic sites, tumor volume, and treatments. There are also paraffin-embedded tissue from primary tumor saved from all individuals, and for a subset of the cohort also frozen primary tumor tissue saved. There is DNA, plasma and serum saved from all individuals. Purpose: To find tumor markers or tumor cells in the blood from patients with metastatic breast cancer. Data collection was started in 2003 and is ongoing (in 2010 there were over 300 individuals included in the study).
citation: CreativeWork
  name: Carlsson MC, Cederfur C, Schaar V, Balog CI, Lepur A, Touret F, Salomonsson E, Deelder AM, Fernö M, Olsson H, Wuhrer M, Leffler H. Galectin-1-binding glycoforms of haptoglobin with altered intracellular trafficking, and increase in metastatic breast cancer patients. PLoS One. 2011;6(10):e26560. doi: 10.1371/journal.pone.0026560. Epub 2011 Oct 18.
citation: CreativeWork
  name: Carlsson A, Wingren C, Kristensson M, Rose C, Fernö M, Olsson H, Jernström H, Ek S, Gustavsson E, Ingvar C, Ohlsson M, Peterson C, Borrebaecka C A.K. Molecular serum portraits in patients with primary breast cancer predict the development of distant metastases. Proc Natl Acad Sci U S A. Aug 23, 2011; 108(34): 14252-14257. doi: 10.1073/pnas.1103125108. Published online Aug 15, 2011.
citation: CreativeWork
  name: Carlsson A, Wingren C, Ingvarsson J, Ellmark P, Baldertorp B, Fernö M, Olsson H, Borrebaeck CA. Serum proteome profiling of metastatic breast cancer using recombinant antibody microarrays. Eur J Cancer. 2008 Feb;44(3):472-80. doi: 10.1016/j.ejca.2007.11.025. Epub 2008 Jan 2.
citation: CreativeWork
  name: Carlsson MC, Balog CI, Kilsgård O, Hellmark T, Bakoush O, Segelmark M, Fernö M, Olsson H, Malmström J, Wuhrer M, Leffler H. Different fractions of human serum glycoproteins bind galectin-1 or galectin-8, and their ratio may provide a refined biomarker for pathophysiological conditions in cancer and inflammatory disease. Biochim Biophys Acta. 2012 Sep;1820(9):1366-72. doi: 10.1016/j.bbagen.2012.01.007. Epub 2012 Jan 17.
conditions of access: https://publications.europa.eu/resource/authority/access-right/NON_PUBLIC
conditions of access: info:eu-repo/semantics/restrictedAccess
creative work status: completed
  type: DefinedTerm
  in defined term set: http://publications.europa.eu/resource/authority/dataset-status
  term code: COMPLETED
creator: Håkan Olsson
  type: Person
  affiliation: Lund University
  family name: Olsson
  given name: Håkan
date modified: 2017-03-21
date published: 2014-09-05
keywords: HEALTH
keywords: Clinical Medicine
  type: DefinedTerm
  term code: 302
keywords: Cancer and Oncology
  type: DefinedTerm
  description: Including: Precision Medicine
  term code: 30203
keywords: Blood Specimen Collection
keywords: Neoplasms
keywords: Biomarkers
keywords: Breast Neoplasms
keywords: DNA
keywords: Serum
keywords: Biomarkers, Tumor
keywords: Plasma
keywords: Paraffin Embedding
keywords: Tissue Embedding
keywords: Scania
keywords: frozen tissue
keywords: EpiHealth
keywords: EpiHealth_Skåne
publisher: Region Skåne
size: QuantitativeValue
  unit text: cases
  value: 310
temporal coverage: 2003
version: 1

Lund University
type: Organization
department: Faculty of Medicine, The Division of Oncology and Pathology

HEALTH
type: DefinedTerm
term code: Health

CANCER
type: DefinedTerm

Blood Specimen Collection
type: DefinedTerm
description: The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.
term code: D001800

Neoplasms
type: DefinedTerm
description: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
term code: D009369

Biomarkers
type: DefinedTerm
description: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, ENVIRONMENTAL EXPOSURE and its effects, disease diagnosis; METABOLIC PROCESSES; SUBSTANCE ABUSE; PREGNANCY; cell line development; EPIDEMIOLOGIC STUDIES; etc.
term code: D015415

Breast Neoplasms
type: DefinedTerm
description: Tumors or cancer of the human BREAST.
term code: D001943

DNA
type: DefinedTerm
description: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
term code: D004247

Serum
type: DefinedTerm
description: The clear portion of BLOOD that is left after BLOOD COAGULATION to remove BLOOD CELLS and clotting proteins.
term code: D044967

Biomarkers, Tumor
type: DefinedTerm
description: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or BODY FLUIDS. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including HORMONES; ANTIGENS; amino and NUCLEIC ACIDS; ENZYMES; POLYAMINES; and specific CELL MEMBRANE PROTEINS and LIPIDS.
term code: D014408

Plasma
type: DefinedTerm
description: The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION.
term code: D010949

Paraffin Embedding
type: DefinedTerm
description: The infiltrating of tissue specimens with paraffin, as a supporting substance, to prepare for sectioning with a microtome.
term code: D016612

Tissue Embedding
type: DefinedTerm
description: The technique of placing cells or tissue in a supporting medium so that thin sections can be cut using a microtome. The medium can be paraffin wax (PARAFFIN EMBEDDING) or plastics (PLASTIC EMBEDDING) such as epoxy resins.
term code: D016610