BIG3 is a Scanian research project in which the name BIG3 is aiming at three major diseases: chronic obstructive pulmonary disease (COPD), cardiovascular diseases and lung cancer. The overall goal of BIG3 is to understand the mechanisms underlying these diseases in order to develop new treatments that can lead to earlier, better and more accurate diagnosis for better and more individualized treatment. BIG3 is an open prospective longitudinal cohort study in Sweden. As a first step, around 100 000 people in Scania between 45 and 75 years have the opportunity to answer a questionnaire about lifestyle, living environment and tobacco habits. Then about 10 000 individuals from the respondents will be summoned to undergo examinations. These include ECG, CT scan of the heart and lungs, pulmonary function tests and blood tests. The blood samples will be analyzed both directly for a number of markers and also stored in a biobank for later analysis. The goal is to try to get about 50% of smokers in the cohort. Ultimately, the study aims to find out which individuals that are at greater risk of developing one or more of the three diseases and why some individuals seem to be protected. Purpose: BIG3 aims to increase understanding and to reduce morbidity / mortality in chronic diseases such as COPD, lung cancer and cardiovascular diseases, and to improve the care and quality of life for individuals with these disorders.
INHALING AND EXHALING THE SMOKE OF BURNING TOBACCO
RECORD OF AN INDIVIDUAL'S ILLNESSES, MEDICAL TREATMENTS, ETC.
The technique that deals with the measurement of the size, weight, and proportions of the human or other primate body.
The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.
Typical way of life or manner of living characteristic of an individual or group. (From APA, Thesaurus of Psychological Index Terms, 8th ed)
Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
Studies in which variables relating to an individual or group of individuals are assessed over a period of time.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.
The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Pathological processes involving any part of the LUNG.
The periodic shedding of the ENDOMETRIUM and associated menstrual bleeding in the MENSTRUAL CYCLE of humans and primates. Menstruation is due to the decline in circulating PROGESTERONE, and occurs at the late LUTEAL PHASE when LUTEOLYSIS of the CORPUS LUTEUM takes place.
Support systems that provide assistance and encouragement to individuals with physical or emotional disabilities in order that they may better cope. Informal social support is usually provided by friends, relatives, or peers, while formal assistance such as COMMUNITY SUPPORT is provided by churches, groups, etc.
THE COMMUNICATION LINKS AMONG INDIVIDUALS THAT FUNCTION VIA FAMILY CONNECTIONS, NEIGHBOURHOOD, WORKPLACE, RECREATIONS, THE INTERNET AND SOCIAL MEDIA