DIWA - Diabetes and Impaired glucose tolerance in Women and Atherosclerosis development study
All 64-year old women in the county of Gothenburg were invited to a screening examination including an OGTT. Glucose tolerance was defined for each participant according to the World Health Organization (WHO) criteria. Patients were divided in three sub-groups according to metabolic status and a randomized sample of patients were recruited from each group for a longitudinal follow-up study: diabetes mellitus (n = 220), impaired glucose tolerance (IGT, n = 204) or normal glucose tolerance (NGT, n = 188). Baseline examination was performed between 2002-2004 and follow-up examination in 2007-2009 (mean follow-up 5.5 years). Datasets from papers published in open access is made available on request. Purpose: The aim of the DIWA-study is to investigate the development of atherosclerosis in women with different degrees of glucose control.
Fagerberg B, Prahl Gullberg U, Alm R, Nilsson J, Nordin Fredrikson G. Circulating autoantibodies against the apolipoprotein B-100 peptides p45 and p210 in relation to the occurrence of carotid plaques in 64-year-old women. PLoS ONE 2015;10(3): e0120744. doi:10.1371/journal.pone.0120744
Bergström G, Fagerberg B, Sallsten G, Lundh T, Barregard L. Is cadmium exposure associated with the burden, vulnerability and rupture of human atherosclerotic plaques? PLOS ONE (in press).
University of Gothenburg, The Sahlgrenska Academy
Studies in which variables relating to an individual or group of individuals are assessed over a period of time.
A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).
Human females as cultural, psychological, sociological, political, and economic entities.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Organized periodic procedures performed on large groups of people for the purpose of detecting disease.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.