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            <r:String xml:lang="sv">Populationsundersökningen av kvinnor i Göteborg (Kvinnoundersökningen, KVUS)</r:String>
            <r:String xml:lang="en">Prospective Population Study of Women in Göteborg (PPSW)</r:String>
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          <r:String xml:lang="sv">Göteborgs universitet</r:String>
          <r:String xml:lang="en">University of Gothenburg</r:String>
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        <r:SimpleDate>2015-04-22</r:SimpleDate>
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      <r:Content xml:lang="sv">H85-studien är en av de longitudinella studierna från Göteborg där representativa populationer av äldre har följts över lång tid (information om studierna H70, 95+ och Kvinnoundersökningen finns under Relaterade studier).
 
H85-studien koordineras gemensamt av flera forskargrupper men bedrivs huvudsakligen vid enheten för neuropsykiatrisk epidemiologi - EPINEP. 

Vid baslinjemätningens hälsoundersökning år 1986/87 inbjöds alla 85-åringar i Göteborg födda 1 juli 1901 till 30 juni 1902 till en hälsoundersökning, hälften av dessa undersöktes av psykiatriker (n=494). Deltagarna har följts upp vid 88-, 90-, 92-, 95-, 97, 99-, 100-, 101, 102- 103- , 104- och 105-års ålder. Svarsfrekvensen har omfattat omkring 65-80%. Studiens undersökningar har genomförts år 1986/87, 1989, 1991, 1993, 1996, 1998, 2000, 2001, 2002, 2003, 2004, 2005, och år 2006.

En andra kohort av 85-åringar födda mellan 1 juli 1923 till och med 30 juni 1924 bjöds in till att delta i studien. Baslinjemätningens undersökning genomfördes under 2008-2010. Antalet deltagare vid baslinjemätningen var 572, vilket motsvarade en svarsfrekvens på omkring 60 %. Deltagarna har därefter följts upp vid 88- och 90 års ålder. Studiens undersökningar har genomförts år 2008-2010, 2011, 2013 samt 2018. Deltagarna planeras att följas upp 2021.

En tredje kohort av 85-åringar födda 1930 inkluderades 2015-16 då 491 individer undersöktes. Deltagarna har följts upp vid 88 års ålder och planeras att undersökas 2021.

Undersökningen omfattar psykiatrisk intervju, somatiska undersökningar, tester av sjukgymnast, psykologtest, blodprov med omfattande laboratorieanalyser samt anhörigintervju. Vidare samlas data in relaterad till socioekonomisk status, civilstånd, levnadsvillkor, bostadssituation, utbildning, religiositet, hobbys och livshändelser. Slutligen ingår neurobiologisk undersökning i form av datortomografi (CT) och magnetröntgen (MR) av hjärnan samt lumbalpunktion och analys av hjärn-ryggmärgsvätska. Journaler från alla större sjukhus, geriatriska och psykiatriska institutioner samt polikliniska mottagningar i Göteborg granskas för att finna fall av psykiska och somatiska sjukdomar. Demens, depression, psykotiska sjukdomar, sömnproblem, ångestsjukdomar, och post-traumatiskt stresssyndrom (PTSS) diagnostiseras enligt DSM-III-R och DSM-IV. Somatiska sjukdomar klassificeras enligt etablerade kriterier.

Syftet är att undersöka frekvens av, samt vilka faktorer som är av betydelse för utveckling av psykisk- och somatisk sjukdom i en population som har följts longitudinellt från 85 års ålder.</r:Content>
      <r:Content xml:lang="en">'H85' is one of the longitudinal studies from Gothenburg where representative populations of older people has been followed over a long period (information about the studies H70, 95+ and Kvinnoundersökningen KVUS can be found under Related studies). This is a multidisciplinary study of representative samples of 85-year olds in Göteborg, which started in 1986.

At the baseline examination during 1986/87 all 85-year-olds born between July 1, 1901 and June 30, 1902 and living in Gothenburg were invited to a health examination. Half of them were also examined by a psychiatrist (n=494). Participants were followed up at age 88, 90, 92, 95, 97, 99, 100, 101, 102, 103, 104 and 105. The study surveys have been conducted in 1986/87, 1989, 1991, 1993, 1996, 1998, 2000, 2001, 2002, 2003, 2004, 2005 and 2006.

A second cohort of 85-year-olds born between July 1, 1923 and June 30, 1924 was invited to the study. At the baseline examination (2008-2010), 572 individuals participated, representing a response rate of 60 %. Participants were followed up at age 88 and 90. The study surveys have been conducted in 2008-2010, 2011, 2013 and 2018. Re-examinations are planned for 2021.

Cohort three of 85-year-olds was included in 2015‒16, where 491 persons born 1930 were examined.  Re-examinations are planned at ages 91 and 95.

The examination procedures at each study have been retained as identical as possible to provide results that can be compared over time. The study comprises a psychiatric interview, physical examination, psychological tests, blood samples with extensive laboratory analysis and a close informant interview. It also includes collecting data related to socioeconomic status, marital status, living conditions, housing situation, education, religion, hobbies and life events. Neurobiological investigations in the form of computed tomography (CT) and magnetic resonance imaging (MRI) of the brain and spinal puncture and analysis of brain-spinal fluid are also carried out. Medical records from all major hospitals, geriatric and psychiatric institutions and outpatient clinics in Gothenburg are evaluated to find cases of psychiatric and somatic diseases. Dementia, depression, psychotic disorders, sleep disorders, anxiety disorders, and post-traumatic stress disorder (PTSD) are diagnosed according to DSM-III-R and DSM-IV. Somatic diseases are classified according to established criteria.

The purpose is to investigate the frequency of, and which factors that are associated with psychiatric and somatic diseases in a population 85-years-old followed longitudinally.</r:Content>
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