H85, kohort 3: 85-åringar födda 1930 H85, kohort 3: 85-year-olds born in 1930 ext0204-3-1 Swedish National Data Service Svensk nationell datatjänst http://neurophys.gu.se/digitalAssets/1533/1533661_avhanbo6_is.pdf H85, kohort 3: 85-åringar födda 1930 H85, kohort 3: 85-year-olds born in 1930 ext0204-3-1 Skoog, Ingmar Skoog, Ingmar Swedish National Data Service Svensk nationell datatjänst http://neurophys.gu.se/digitalAssets/1533/1533661_avhanbo6_is.pdf Aged Äldre Psychology Psykologi Physical Examination Hälsokontroll Dementia Demens Psychiatry Psykiatri Geriatric Psychiatry Äldrepsykiatri Geriatric Nursing Äldrevård Memory Minne Longitudinal Studies Longitudinella studier Risk Factors Riskfaktorer Mortality Dödlighet Health Hälsa HEALTH HÄLSA Elderly Äldre 'H85' is one of the longitudinal studies from Gothenburg where representative populations of older people has been followed over a long period. (Information about the studies H70, 95+ and Kvinnoundersökningen KVUS can be found under the tab Related studies.) This is a multidisciplinary study of representative samples of 85-year olds in Göteborg, which started in 1985 and is jointly managed by the Departments of Psychiatry and Psychology. In 1986-87 all 85-year-olds born between July 1, 1901 and June 30, 1902 and registered for census purposes in Gothenburg, Sweden, were invited to take part in a health control. Half of them were also examined by a psychiatrist (n=494). Follow-up studies have been done at ages 88, 90, 92, 95, 97, 99, 100, 101, 102, 103, 104 and and the response rate has remained at 65-80%. Another cohort of 85-year-olds born July 1, 1923 till June 30, 1924 were examined from 2008 to 2010 (N = 572, response rate 60%). These will be followed up in the same way as 85-year-olds born in 1901-02. A new H85 study of the birth cohort born in 1930 is planned during 2015. The studies include psychiatric, somatic, functional and social examinations, psychometric tests, personality inventories, DNA-analyses, laboratory tests, head CT-scan, and cerebrospinal fluid analyses. Purpose: To investigate the frequency of, and which factors that are associated with psychiatric and somatic diseases in a population 85 years old followed longitudinally. Studien H85 är en av de longitudinella studierna från Göteborg där representativa populationer av äldre har följts över lång tid. (Information om studierna H70, 95+ och Kvinnoundersökningen finns via fliken Relaterade studier.) H85-studien koordineras gemensamt av flera forskargrupper men bedrivs huvudsakligen vid enheten för neuropsykiatrisk epidemiologi - EPINEP. 1986-87 inbjöds alla 85-åringar i Göteborg födda 1 juli 1901 till 30 juni 1902 till en hälsoundersökning av vilka hälften undersöktes av psykiatriker (n=494). Uppföljande studier har gjorts vid 88-, 90-, 92-, 95-, 97-, 99-, 100-, 101-, 102-, 103-, 104- och 105 års ålder, med svarsfrekvens mellan 65-80 %. Ytterligare en kohort av 85-åringar födda 1 juli 1923 till 30 juni 1924 undersöktes mellan 2008-2010 och har därefter följts longitudinellt. En kommande studie av 85-åringar födda 1930 är planerad år 2015. Studierna omfattar psykiatrisk, social och somatisk undersökning, psykometriska tester, personlighetsundersökning, funktionsbedömning, DNA-analyser, laboratorieundersökningar, datortomografi av hjärna och likvorundersökning. Syfte: Att undersöka frekvens av, samt vilka faktorer som är av betydelse för utveckling av psykisk- och somatisk sjukdom i en population följd longitudinellt från 85 års ålder Sweden Sverige IndividualIndividual IndividIndivid The population originally consisted of a representative sample of 85-year-old men and women born in 1901/1902 and living in Gothenburg 1986/1987. Den ursprungliga populationen bestod av ett representativt urval av 85-åriga män och kvinnor födda 1901/1902 och boende i Göteborg 1986/1987, som sedan följts longitudinellt. Fler kohorter av 85-åringar har inkluderats i studien. Numeric Longitudinal: Cohort/Event-basedLongitudinal: Cohort/Event-based Longitudinell: Kohort/HändelsebaseradLongitudinell: Kohort/Händelsebaserad The study participants were mainly drawn as a representative, systematic sample from the population register.The study participants were mainly drawn as a representative, systematic sample from the population register. Deltagarna har huvudsakligen valts ut genom ett representativt, systematiskt urval från befolkningsregistret.Deltagarna har huvudsakligen valts ut genom ett representativt, systematiskt urval från befolkningsregistret. Probability: Systematic randomProbability: Systematic random Sannolikhetsurval: systematiskt slumpmässigt urvalSannolikhetsurval: systematiskt slumpmässigt urval Access to data through an external actor. Access to data is restricted. Åtkomst till data via extern aktör. Tillgång till data är begränsad. restrictedAccess Liebetrau M, Steen B, Skoog I. Depression as a risk factor for the incidence of first-ever stroke in 85-year-olds. Stroke 2008;39:1960-1965. Liebetrau M, Steen B, Skoog I. Depression as a risk factor for the incidence of first-ever stroke in 85-year-olds. Stroke 2008;39:1960-1965. 2008 Aevarsson O, Svanborg A, Skoog I. Seven-year survival after age 85 years. Relation to Alzheimer disease and vascular dementia. Arch Neurol 1998;55:1226-1232. Aevarsson O, Svanborg A, Skoog I. Seven-year survival after age 85 years. Relation to Alzheimer disease and vascular dementia. Arch Neurol 1998;55:1226-1232. 1998 Skoog I, Vanmechelen E, Andreasson L-A, Palmertz B, Davidsson P, Hesse C, Blennow K. A population-based study of tau protein and ubiquitin in cerebrospinal fluid in 85-year-olds: relation to severity of dementia and cerebral atrophy, but not to the apolipoprotein E4 allele. Neurodegeneration 1995;4:433-442. Skoog I, Vanmechelen E, Andreasson L-A, Palmertz B, Davidsson P, Hesse C, Blennow K. A population-based study of tau protein and ubiquitin in cerebrospinal fluid in 85-year-olds: relation to severity of dementia and cerebral atrophy, but not to the apolipoprotein E4 allele. Neurodegeneration 1995;4:433-442. 1995 Skoog I, Hesse C, Fredman P, Andreasson L-A, Palmertz B, Blennow K. Apolipoprotein E in cerebrospinal fluid in 85-year-olds. Relation to dementia, apolipoprotein E polymorphism, cerebral atrophy, and white-matter lesions. Arch Neurol 1997; 54: 267-272. Skoog I, Hesse C, Fredman P, Andreasson L-A, Palmertz B, Blennow K. Apolipoprotein E in cerebrospinal fluid in 85-year-olds. Relation to dementia, apolipoprotein E polymorphism, cerebral atrophy, and white-matter lesions. Arch Neurol 1997; 54: 267-272. 1997 Skoog I, Steen B, Persson G, Nilsson L, Aevarsson O, Larsson L, Östling S. A 15-year longitudinal cross-sectional population study on sleep in the elderly. Facts and research in gerontology 1993;7:137-146. Skoog I, Steen B, Persson G, Nilsson L, Aevarsson O, Larsson L, Östling S. A 15-year longitudinal cross-sectional population study on sleep in the elderly. Facts and research in gerontology 1993;7:137-146. 1993 Skoog I, Nilsson L, Landahl S, Steen B. Mental disorders and the use of psychotropic drugs in an 85-year-old urban population. Int Psychogeriatrics 1993;5:33-48. Skoog I, Nilsson L, Landahl S, Steen B. Mental disorders and the use of psychotropic drugs in an 85-year-old urban population. Int Psychogeriatrics 1993;5:33-48. 1993 Skoog I, Andreasson L-A, Palmertz B, Lernfeldt B, Landahl S, Steen B, Svanborg A. Vascular factors and dementia in 85-year-olds. In: Bergener M, Brocklehurst JC, Finkel SI (eds). Aging, Health, and Healing. New York: Springer Publishing Company Inc 1995; 49-55. Skoog I, Andreasson L-A, Palmertz B, Lernfeldt B, Landahl S, Steen B, Svanborg A. Vascular factors and dementia in 85-year-olds. In: Bergener M, Brocklehurst JC, Finkel SI (eds). Aging, Health, and Healing. New York: Springer Publishing Company Inc 1995; 49-55. 1995 Skoog I, Nilsson L, Svanborg A. The authors reply: A population-based study of dementia in 85-year-olds. N Engl J Med 1993;329:363. Skoog I, Nilsson L, Svanborg A. The authors reply: A population-based study of dementia in 85-year-olds. N Engl J Med 1993;329:363. 1993 Skoog I, Palmertz B, Andreasson L-A. The prevalence of white matter lesions on computed tomography of the brain in demented and non-demented 85-year-olds. J Geriatr Psychiatry Neurol 1994;7:169-175. Skoog I, Palmertz B, Andreasson L-A. The prevalence of white matter lesions on computed tomography of the brain in demented and non-demented 85-year-olds. J Geriatr Psychiatry Neurol 1994;7:169-175. 1994 Östling S, Johansson B, Skoog I. Cognitive test performance in relation to psychotic symptoms and paranoid ideation in non-demented 85-year-olds. Psychol Med 2004;34:443-450. Östling S, Johansson B, Skoog I. Cognitive test performance in relation to psychotic symptoms and paranoid ideation in non-demented 85-year-olds. Psychol Med 2004;34:443-450. 2004 Sacuiu S, Sjögren M, Gustafson D, Skoog I. Prodromal cognitive signs of dementia in 85-year-olds using four sources of information. Neurology 2005;65:1894-1900. Sacuiu S, Sjögren M, Gustafson D, Skoog I. Prodromal cognitive signs of dementia in 85-year-olds using four sources of information. Neurology 2005;65:1894-1900. 2005 Palsson S, Aevarsson O, Skoog I. Depression, cerebral atrophy, cognitive performance and incidence of dementia. Population study of 85-year-olds. Brit J Psychiatr 1999;174:249-253. Palsson S, Aevarsson O, Skoog I. Depression, cerebral atrophy, cognitive performance and incidence of dementia. Population study of 85-year-olds. Brit J Psychiatr 1999;174:249-253. 1999 Östling S, Gustafson D, Blennow K, Börjesson-Hanson A, Waern M. Psychotic symptoms in a population-based sample of 85-year-old individuals with dementia. J Geriatr Psychiatry Neurol. 2011 Mar;24(1):3-8. Östling S, Gustafson D, Blennow K, Börjesson-Hanson A, Waern M. Psychotic symptoms in a population-based sample of 85-year-old individuals with dementia. J Geriatr Psychiatry Neurol. 2011 Mar;24(1):3-8. 2011 Nilsson L, Persson G, Skoog I. Unik Svensk undersökning i Göteborg 85-åringar positiva till sexundersökningar. Ottar 1988;113-118. Nilsson L, Persson G, Skoog I. Unik Svensk undersökning i Göteborg 85-åringar positiva till sexundersökningar. Ottar 1988;113-118. 1988 Hellström L, Milsom I, Ekelund P, Skoog I. The influence of dementia on the prevalence of urinary and faecal incontinence in 85-year old men and women. Archives of Gerontology and Geriatrics 1994;19:11-20. Hellström L, Milsom I, Ekelund P, Skoog I. The influence of dementia on the prevalence of urinary and faecal incontinence in 85-year old men and women. Archives of Gerontology and Geriatrics 1994;19:11-20. 1994 Skoog I. Sex and Swedish 85-year-olds. N Engl J Med 1996;334:1140-1141. Skoog I. Sex and Swedish 85-year-olds. N Engl J Med 1996;334:1140-1141. 1996 Palsson S, Johansson B, Berg S, Skoog I. A population study on the influence of depression on neuropsychological functioning in 85-year-olds. Acta Psychiatr Scand 2000;101:185-193. Palsson S, Johansson B, Berg S, Skoog I. A population study on the influence of depression on neuropsychological functioning in 85-year-olds. Acta Psychiatr Scand 2000;101:185-193. 2000 Olesen PJ, Guo X, Gustafson D, Börjesson-Hanson A, Sacuíu S, Eckerström C, Bigler ED, Skoog I. A population-based study on the influence of brain atrophy on 20-year survival after age 85. Neurology 2011;76(10):879-86 Olesen PJ, Guo X, Gustafson D, Börjesson-Hanson A, Sacuíu S, Eckerström C, Bigler ED, Skoog I. A population-based study on the influence of brain atrophy on 20-year survival after age 85. Neurology 2011;76(10):879-86 2011 Liebetrau M, Steen B, Hamann GF, Skoog I. Silent and symptomatic infarcts on cranial computerized tomography in relation to dementia and mortality. A populationbased study in 85-year-olds. Stroke 2004;35:1816-1820. Liebetrau M, Steen B, Hamann GF, Skoog I. Silent and symptomatic infarcts on cranial computerized tomography in relation to dementia and mortality. A populationbased study in 85-year-olds. Stroke 2004;35:1816-1820. 2003 Skoog I, Hesse C, Aevarsson O, Landahl S, Wahlström J, Fredman P, Blennow K. A population study of Apo E genotype at the age of 85: relation to dementia, cerebrovascular disease and mortality. J Neurol Neurosur Psychiatr 1998;64:37-43. Skoog I, Hesse C, Aevarsson O, Landahl S, Wahlström J, Fredman P, Blennow K. A population study of Apo E genotype at the age of 85: relation to dementia, cerebrovascular disease and mortality. J Neurol Neurosur Psychiatr 1998;64:37-43. 1998 Skoog I, Berg S, Johansson B, Palmertz B, Andreasson L-A. The influence of white matter lesions on neuropsychological functioning in demented and non-demented 85-year-olds. Acta Neurol Scand 1996;93:142-148. Skoog I, Berg S, Johansson B, Palmertz B, Andreasson L-A. The influence of white matter lesions on neuropsychological functioning in demented and non-demented 85-year-olds. Acta Neurol Scand 1996;93:142-148. 1996 Skoog I, Aevarsson O, Beskow J, Larsson L, Palsson S, Waern M, Landahl S, Östling, S. Suicidal feelings in a population sample of non-demented 85-year-olds. Am J Psychiatry 1996;153:1015-1020. Skoog I, Aevarsson O, Beskow J, Larsson L, Palsson S, Waern M, Landahl S, Östling, S. Suicidal feelings in a population sample of non-demented 85-year-olds. Am J Psychiatry 1996;153:1015-1020. 1996 Liebetrau M, Steen B, Skoog I. Stroke in 85-year-olds. Prevalence, incidence, risk factors and relation to mortality and dementia. Stroke 2003;34:2617-2622. Liebetrau M, Steen B, Skoog I. Stroke in 85-year-olds. Prevalence, incidence, risk factors and relation to mortality and dementia. Stroke 2003;34:2617-2622. 2003 Skoog I. The prevalence of psychotic, depressive and anxiety syndromes in demented and non-demented 85-year-olds. Int J Geriatric Psychiatry 1993;8:247-253. Skoog I. The prevalence of psychotic, depressive and anxiety syndromes in demented and non-demented 85-year-olds. Int J Geriatric Psychiatry 1993;8:247-253. 1993 Johansson C, Skoog I. A population-based study on the association between dementia and hip fractures in 85-year-olds. Aging Clin Exp Res 1996;8:189-196. Johansson C, Skoog I. A population-based study on the association between dementia and hip fractures in 85-year-olds. Aging Clin Exp Res 1996;8:189-196. 1996 Skoog I. Andresson L-A, Palmertz B, Landahl S, Lernfelt B. A population-based study on blood pressure and brain atrophy in 85-year-olds. Hypertension 1998; 32: 404-409. Skoog I. Andresson L-A, Palmertz B, Landahl S, Lernfelt B. A population-based study on blood pressure and brain atrophy in 85-year-olds. Hypertension 1998; 32: 404-409. 1998 Skoog I, Davidsson P, Aevarsson O, Vanderstichele H, Vammechelen E, Blennow K. Cerebrospinal Fluid Beta-Amyloid 42 Is Reduced before the Onset of Sporadic Dementia: A Population-Based Study in 85-Year-Olds. Dement geriatr Cogn Disord 2003;15:169-176. Skoog I, Davidsson P, Aevarsson O, Vanderstichele H, Vammechelen E, Blennow K. Cerebrospinal Fluid Beta-Amyloid 42 Is Reduced before the Onset of Sporadic Dementia: A Population-Based Study in 85-Year-Olds. Dement geriatr Cogn Disord 2003;15:169-176. 2003 Skoog I, Nilsson L, Palmertz B, Andreasson L-A, Svanborg A. A population-based study of dementia in 85-year-olds. N Engl J Med 1993; 328:153-158 Skoog I, Nilsson L, Palmertz B, Andreasson L-A, Svanborg A. A population-based study of dementia in 85-year-olds. N Engl J Med 1993; 328:153-158 1993 Skoog I, Wallin A, Fredman P, Hesse C, Aevarsson O, Karlsson I, Gottfries CG, Blennow K. A population-study on blood-brain barrier function in 85-year-olds. Relation to Alzheimer’s disease and vascular dementia. Neurology 1998;50:966-971. Skoog I, Wallin A, Fredman P, Hesse C, Aevarsson O, Karlsson I, Gottfries CG, Blennow K. A population-study on blood-brain barrier function in 85-year-olds. Relation to Alzheimer’s disease and vascular dementia. Neurology 1998;50:966-971. 1998