The PEAK-25 cohort
type: Dataset
description: The PEAK25-cohort, women 25 yrs at inclusion, addresses factors contributing to peak bone mass. In 2014 the PEAK25 cohort is still unique since there are no cohorts nationally or internationally which have been specifically designed to identify genetic and other risk factors for bone strength at this critical age or which has been followed longitudinally. By investigating 10yr change in BMD we have the potential to identify genes important for bone homeostasis, without confounding from perimenopausal hormonal changes. Parents and grand-parents have also been collected. This cohort is an important resource in terms of providing normative data for young Swedish women, providing reference data for future studies in women and investigating long-term changes in risk factors in pre-menopausal women. In PEAK-25, a total of 1,061 (response rate 49 %) underwent baseline investigation (1999-2004). Enrollment was continuous throughout the year to avoid seasonal bias. All women were 25 years old at inclusion. Exclusion criteria was pregnancy at the time of the baseline investigation or during the 12 months prior to inclusion. The cohort was followed up at 10-years. The investigations included bone mineral density (BMD) and body composition measurements, anthropometrics and BioDex isokinetic muscle force. Questionnaires provide information on lifestyle, recreational physical activity, health, food/nutrition, birthweight and hormonal function. Validated instruments for outcome (SF-36, EQ5D and Qualeffo-radius), ADL-function are also available. Information on fractures sustained prior to baseline and during followup were collected. Blood and urine samples were collected. Extensive phenotyping includes: bone turnover markers and a number of serum markers GWAS genotyping will be available in Spring 2017 (Illumina GSA Arrays “Infinium iSelect 24x1 HTS Custom Beadchip Kit”). Purpose: This cohort was designed to include women at an age closely representing ‘pure’ peak bone mass, prior …
alternate name: PEAK25-kohorten
conditions of access: https://publications.europa.eu/resource/authority/access-right/NON_PUBLIC
conditions of access: info:eu-repo/semantics/restrictedAccess
contributor: Region Skåne
creative work status: completed
  type: DefinedTerm
  in defined term set: http://publications.europa.eu/resource/authority/dataset-status
  term code: COMPLETED
creator: Kristina Åkesson
date modified: 2024-10-30
date published: 2017-03-02
funding: Grant
  funder: Swedish Research Council
keywords: HEALTH
keywords: Medical and Health Sciences
  type: DefinedTerm
  term code: 3
keywords: Activities of Daily Living
keywords: Blood Specimen Collection
keywords: Body Composition
keywords: Longitudinal Studies
keywords: Osteoporosis
keywords: Urine Specimen Collection
keywords: Women
keywords: Phenotype
keywords: Bone Density
keywords: Anthropology
keywords: Premenopause
keywords: EpiHealth_Skåne
keywords: Cohorts.se
publisher: Lund University
size: QuantitativeValue
  unit text: cases
  value: 1061
spatial coverage: Sweden
spatial coverage: Skåne County
temporal coverage: 1999-01-01
distribution: documentation/List of publicationsPEAK25.pdf
  type: DataDownload
  additional type: documentation
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 520694
  encoding format: application/pdf
version: 1

Kristina Åkesson
type: Person
affiliation: Lund University
family name: Åkesson
given name: Kristina

Lund University
type: Organization
department: Department of Clinical Sciences

HEALTH
type: DefinedTerm
term code: Health

Activities of Daily Living
type: DefinedTerm
description: The performance of the basic activities of self care, such as dressing, ambulation, or eating.
term code: D000203

Blood Specimen Collection
type: DefinedTerm
description: The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.
term code: D001800

Body Composition
type: DefinedTerm
description: The relative amounts of various components in the body, such as percentage of body fat.
term code: D001823

Longitudinal Studies
type: DefinedTerm
description: Studies in which variables relating to an individual or group of individuals are assessed over a period of time.
term code: D008137

Osteoporosis
type: DefinedTerm
description: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
term code: D010024

Urine Specimen Collection
type: DefinedTerm
description: Methods or procedures used to obtain samples of URINE.
term code: D059349

Women
type: DefinedTerm
description: Human females as cultural, psychological, sociological, political, and economic entities.
term code: D014930

Phenotype
type: DefinedTerm
description: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
term code: D010641

Bone Density
type: DefinedTerm
description: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
term code: D015519

Anthropology
type: DefinedTerm
description: The science devoted to the comparative study of man.
term code: D000883

Premenopause
type: DefinedTerm
description: The period before MENOPAUSE. In premenopausal women, the climacteric transition from full sexual maturity to cessation of ovarian cycle takes place between the age of late thirty and early fifty.
term code: D017697

Sweden
type: Place

Skåne County
type: Place