WOLF - Psykisk arbetsbelastning och indikatorer för kronisk hjärt- och kärlsjukdom WOLF - Mental workload and indicators of chronic cardiovascular diseases snd0847-1-1 Swedish National Data Service Svensk nationell datatjänst http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-627 http://swepub.kb.se/bib/swepub:oai:DiVA.org:umu-19144 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-19144 http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-3137 http://swepub.kb.se/bib/swepub:oai:DiVA.org:miun-3137 WOLF - Psykisk arbetsbelastning och indikatorer för kronisk hjärt- och kärlsjukdom WOLF - Mental workload and indicators of chronic cardiovascular diseases snd0847-1-1 Westerlund, Hugo Westerlund, Hugo Åkerstedt, Torbjörn Åkerstedt, Torbjörn Alfredsson, Lars Alfredsson, Lars Westerholm, Peter Westerholm, Peter Knutsson, Anders Knutsson, Anders Fahlén, Göran Fahlén, Göran Goine, Hans Goine, Hans Nordin, Maria Nordin, Maria Karlsson, Bernt Karlsson, Bernt Fransson, Eleonor Fransson, Eleonor Theorell, Töres Theorell, Töres Swedish National Data Service Svensk nationell datatjänst Swedish Cohort Consortium (Cohorts.se) The Swedish Cohort Consortium (Cohorts.se) is a project aimed at improving management and increasing the use of Swedish population-based cohorts (research databases with sensitive person data) for world-leading research. Coordination of all Swedish prospective population-based cohorts in a common infrastructure will enable more precise research findings and facilitate research on rare diseases and exposures, leading to better utilization of study participants’ data, better return of funders’ investments, and higher benefit to patients and populations. Cohorts.se will support some aspects of single cohort operations and all aspects of collaborations between cohorts. Important components of the infrastructure involve data curation and management, cataloguing of variables, presentation of and access to data, harmonization of variables for research projects, linkage of cohorts and official registries, and statistical analysis including a novel method for distributed data analysis eliminating the need to share data. The project aims to increase collaboration between Swedish universities and with international cohort consortia, and to be a node for researchers who want to collaborate, perhaps extra important for young researchers without a large contact network. SND collaborates with Cohorts.se. Partly through training of data managers and statisticians in the Maelstrom system (maelstrom-research.org), which is tailored for cohort collaboration and will be used in this infrastructure; partly through collaboration around logistics by forwarding researchers seeking access to person data from cohorts to Cohorts.se and the Maelstrom repository. Contact for Cohorts.se: Johan Sundström, Professor at UCR-Uppsala Clinical Research center johan.sundstrom@ucr.uu.se The Swedish Cohort Consortium (Cohorts.se) är ett projekt som syftar till att förbättra förvaltningen och öka utnyttjandet av svenska populationsbaserade kohorter (forskningsdatabaser med känsliga individdata) för världsledande forskning. Genom samutnyttjande av många kohorter kan vi skapa säkrare forskningsresultat till bättre nytta för patienter och allmänhet. Infrastrukturen kommer att omfatta kohorter med känsliga individdata och metadata, mjukvara, och servicetjänster. Infrastrukturen kommer att kurera data, katalogisera kohorter, förvalta kohorter, administrera datauttag och -insättningar och länkningar till andra register, harmonisera variabler vid sammanläggningsprojekt, genomföra statistisk analys, och genomföra utbildningsinsatser. Långsiktig professionell kohortförvaltning som inte är personberoende ger ökad säkerhet och kvalitet. Uniform katalogisering och dokumentation och uniforma uttagsprocesser ger ökad tillgänglighet. Infrastrukturen ger ökat utnyttjande av redan insamlade kohorter, och därmed ökat värde för skattebetalarnas grundinvesteringar i kohorterna. Infrastrukturen kan öka samarbeten mellan svenska lärosäten och med internationella kohortkonsortier, och den kan vara en nod för forskare som vill samarbeta, kanske extra viktigt för unga forskare utan stort kontaktnät. SND samarbetar med Cohorts.se. Dels genom utbildning av data managers och statistiker i den för ändamålet designade mjukvara som framförallt används i infrastrukturen, Maelstrom (maelstrom-research.org). Dels genom att forskare som vill ha tillgång till individdata från kohorter lotsas vidare från SND till Cohorts.se och Maelstrom-katalogen. Kontaktperson Cohorts.se: Johan Sundström, Professor vid Institutionen för medicinska vetenskaper, Uppsala universitet johan.sundstrom@ucr.uu.se http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-627 http://swepub.kb.se/bib/swepub:oai:DiVA.org:umu-19144 http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-19144 http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-3137 http://swepub.kb.se/bib/swepub:oai:DiVA.org:miun-3137 Blood Pressure Blodtryck Blood Specimen Collection Blodprovstagning Heart Failure Hjärtsvikt Exercise Träning Socioeconomic Factors Socioekonomiska faktorer Emotions Emotioner Anxiety Ångest Myocardial Infarction Hjärtinfarkt Stroke Stroke Diet Kost Alcohol Drinking Alkoholkonsumtion Alcohol-Related Disorders Alkoholmissbruk Medical History Taking Anamnes Work Arbete Workload Arbetsbelastning Psychology, Industrial Arbetspsykologi Job Satisfaction Arbetstillfredsställelse Decision Making Beslutsfattande Chest Pain Bröstsmärta Noise Buller Diabetes Mellitus Diabetes Lipids Fetter Fibrinogen Fibrinogen Leisure Activities Fritidsaktiviteter Parturition Födande Intermittent Claudication Kärlkramp i benen Pregnancy Graviditet Cardiovascular Diseases Kardiovaskulära sjukdomar Health Hälsa Hypertension Högt blodtryck Cholesterol Kolesterol Angina Pectoris Kärlkramp Life Change Events Livsavgörande händelser Air Pollutants Luftförorenande ämnen Drug Utilization Läkemedelsförsörjning Menstruation Menstruation Environmental Exposure Miljöexponering Interpersonal Relations Mellanmänskliga relationer Personality Personlighet Contraceptives, Oral P-piller Smoking Rökning Self Concept Självuppfattning Social Support Socialt stöd Stress, Psychological Psykologisk stress Sleep Sömn Occupational Exposure Yrkesmässig exponering DRUG ABUSE DROGMISSBRUK OCH MEDICINMISSBRUK HEALTH HÄLSA Specific diseases, disorders and medical conditions Specifika sjukdomar, störningar och medicinska tillstånd General health and well-being Allmän hälsa och välbefinnande Working conditions Arbetsförhållanden Social behaviour and attitudes Socialt beteende och attityder Diet and nutrition Kost och näring WOLF is a study that started in Stockholm in 1993. The acronym WOLF stands for Work-Lipids-Fibrinogen. The study is a collaboration between the former Working Environment Institute, the Institute of Environmental Health and the Institute of Psychosocial Environmental Health at Karolinska Institute and the Institute of Social Medicine in Sundbyberg. WOLF makes up a collaboration program with the included partial projects WOLF-Stockholm, WOLF-Norrland and WOLF-F (The importance of work organisation and psychosocial strain factors to stress related poor health, five year follow up of WOLF-Norrland). Main question formulation: Mental work load (stress) and indications for chronic cardiovascular disease. This original and general program idea has been developed and detailed in the partial projects WOLF-Stockholm (WOLF-S), WOLF-Norrland (WOLF-N) and WOLF-F (the five year follow up of WOLF-N). WOLF-Stockholm (WOLF-S) Project term: The importance of psychosocial working environment for the risk factors for heart attack. A study in psychosocial working environment, blood pressure, blood lipids, fibrinogen etc. (WOLF-Stockholm). Project manager: Lars Alfredsson, the Institute of Environmental Health, Karolinska Institute, Stockholm. Study population: 5 698 employees at companies connected to occupational health care. Studied from June 1993 to June 1995. Method: Health examination with focus on cardiovascular disease, blood pressure measurement. Blood samples for biochemical analysis (the laboratory concern CALAB, Stockholm) + questionnaires. WOLF-Norrland (WOLF-N) In 1995 WOLF established cooperation with the University of Umeå and started the project WOLF-N with the operative management located at the occupational and environmental medicine clinic at the University Hospital of Norrland (Anders Knutsson). Project term: Questions on associations between risk indicators of heart attack and mental work strain related to factors in work organisation, working environment and work content (WOLF-Norrland). Project manager: Anders Knutsson, Mittuniversitetet, Sundsvall, (former University of Umeå). Study population: 4 715 employees at companies connected to occupational health care. Studied from September 1996 to April 1998. Method and organisation with some modifications and additions, same as for WOLF-Stockholm. WOLF-F (WOLF-Follow up project, continuation of WOLF-N) During year 2000 WOLF-F was planned with field organisations and investigational populations in northern Sweden (Norrland). WOLF-F was given two directions: 1) WOLFF - Individual follow-up (WOLFF-I) consisted of a follow-up of the earlier examined population of WOLF-Norrland. Project term: The importance of work organisation and psychosocial factors for stress related poor health. A five year follow-up of WOLF-Norrland. Project manager: Anders Knutsson, Mittuniversitetet, Sundsvall. 2) WOLF - Healthy Work Places - Work Organisation (arbetsorganisation) (WOLF-AO) with focus on questions on work organisation and health with elaboration and widening of data collection and interview material. Project term: Healthy workplaces - A study on relations of organisations and individuals and health. Project manager: Staffan Marklund and Annika Härenstam, Working Life Institute (Arbetslivsinstitutet), Stockholm. Study population: 32 selected companies, 90 work places and about 4300 employees. To a large extent coinciding with the examined population of WOLF-Norrland. WOLF U (WOLF Follow up) In 2009, all participants who previously responded to a WOLF-questionnaire were asked to fill in a follow-up questionnaire (WOLF-U). The survey included questions about work environment, lifestyle and health. The response was positive and about 6 500 people answered the survey. The follow up did not include a health examination. Purpose: To study effect of work and lifestyle on health WOLF är paraplybenämningen på ett FoU-program som har en historik i ett projekt WOLF-Stockholm (Work-Lipids-Fibrinogen) som inleddes i Stockholm 1993 som ett samarbetsprojekt mellan dåvarande Arbetsmiljöinstitutet, Karolinska Institutet, Institutet för Miljömedicin (IMM), Karolinska Institutet, Institutet för Psykosocial Miljömedicin (IPM) och Karolinska Institutet, Socialmedicinska Institutionen i Sundbyberg. WOLF utgör ett samarbetsprogram med de ingående delprojekten WOLF-Stockholm, WOLF-Norrland och WOLF-F (Arbetsorganisationens och psykosociala belastningsfaktorers betydelse för stressrelaterad ohälsa, en femårsuppföljning av WOLF-Norrland). Huvudfrågeställning/Inriktning: Psykisk arbetsbelastning (stress) och indikatorer för kronisk hjärt- och kärlsjukdom. Denna ursprungliga och övergripande programidé har utvecklats och preciserats i delprojekten WOLF-Stockholm (WOLF-S), WOLF-Norrland (WOLF-N) och WOLF-F (5-årsuppföljning av WOLF-N). WOLF-Stockholm (WOLF-S) Projektbenämning: Den psykosociala arbetsmiljöns betydelse för riskfaktorer för hjärtinfarkt. En undersökning om psykosocial arbetsmiljö, blodtryck, blodlipider, fibrinogen m m (WOLF-Stockholm). Projektledare: Lars Alfredsson, Institutet för Miljömedicin, Karolinska institutet, Stockholm och Peter Westerholm, Arbetslivsinstitutet, Stockholm. Studiepopulation: 5.698 anställda vid företag anslutna till företagshälsovård. Undersökta juli 1993 - juni 1995. Metod: Hälsoundersökning med inriktning mot hjärt- kärlsjukdom, blodtrycksmätning. Blodprov för biokemisk analys (Laboratorieföretaget CALAB, Stockholm) + enkätformulär. WOLF-Norrland (WOLF-N) WOLF etablerade 1995 ett samarbete med Umeå Universitet och inledde projektet WOLF-N med den operativa ledningen förlagd till yrkes- och miljömedicinska kliniken, Norrlands Universitetssjukhus (Anders Knutsson). Projektbenämning: Frågor om samband mellan hjärtinfarkts riskindikatorer och psykisk arbetsbelastning relaterad till faktorer i arbetsorganisation, arbetsmiljö och arbetsinnehåll (WOLF-Norrland). Projektledare: Anders Knutsson, Mittuniversitet, Sundsvall (tidigare Umeå Universitet). Studiepopulation: 4.715 anställda vid företag anslutna till företagshälsovård. Undersökta september 1996 - april 1998. Metod och organisation med vissa modifikationer och tillägg, samma som för WOLF-Stockholm. WOLF-F (WOLF-Fortsättningsprojekt, uppföljning av WOLF-N) Under år 2000 vidtog planering av WOLFF med fältorganisation och undersöknings-populationer i Norrland. WOLF-F gavs två inriktningar: 1) WOLFF-Individuppföljning (WOLFF-I) omfattande en uppföljning av den tidigare undersökta populationen i WOLF-Norrland. Projektbenämning: Arbetsorganisationens och psykosociala belastningsfaktorers betydelse för stressrelaterad ohälsa. En femårsuppföljning av WOLF-Norrland. Projektledare: Anders Knutsson, Mittuniversitetet, Sundsvall. 2) WOLFF-Friska arbetsplatser - Arbetsorganisation (WOLFF-AO) med inriktning mot frågor om arbetsorganisation och hälsa med fördjupning och breddning av datainsamling och intervjumaterial. Projektbenämning: Friska arbetsplatser - en studie av organisationsförhållanden, individförhållanden och hälsa. Projektledare: Staffan Marklund och Annika Härenstam, Arbetslivsinstitutet, Stockholm Studiepopulation: 32 utvalda företag, 90 arbetsplatser och ca 4.300 anställda. I stor utsträckning sammanfallande med undersökningspopulationen i WOLF-Norrland. WOLF-U (WOLF Uppföljning) År 2009 tillfrågades alla som någon gång fyllt i ett WOLF-formulär om de ville fylla i en uppföljningsenkät (WOLF-U). Enkäten innehöll frågor om arbetsmiljö, livsstil och hälsa. Responsen var positiv och ca 6 500 personer besvarade enkäten. I den här uppföljningsstudien ingick ingen hälsoundersökning. Syfte: Studera arbetslivets och livsstilens påverkan på hälsa 1993-07 1995-06 1993-07 1995-06 1995-09 1998-04 1995-09 1998-04 2000 2003 2000 2003 2009 2009 Sweden Sverige IndividualIndividual IndividIndivid Numeric LongitudinalLongitudinal LongitudinellLongitudinell WOLF-StockholmWOLF-Stockholm WOLF-StockholmWOLF-Stockholm Physical measurements and testsPhysical measurements and tests Fysiska mätningar och testerFysiska mätningar och tester WOLF-StockholmWOLF-Stockholm WOLF-StockholmWOLF-Stockholm Self-administered questionnaire: PaperSelf-administered questionnaire: Paper Självadministrerat frågeformulär: papperSjälvadministrerat frågeformulär: papper WOLF-NorrlandWOLF-Norrland WOLF-NorrlandWOLF-Norrland Physical measurements and testsPhysical measurements and tests Fysiska mätningar och testerFysiska mätningar och tester WOLF-NorrlandWOLF-Norrland WOLF-NorrlandWOLF-Norrland Self-administered questionnaire: PaperSelf-administered questionnaire: Paper Självadministrerat frågeformulär: papperSjälvadministrerat frågeformulär: papper WOLFF-AOWOLFF-AO WOLFF-AOWOLFF-AO Physical measurements and testsPhysical measurements and tests Fysiska mätningar och testerFysiska mätningar och tester WOLFF-AOWOLFF-AO WOLFF-AOWOLFF-AO Self-administered questionnaire: PaperSelf-administered questionnaire: Paper Självadministrerat frågeformulär: papperSjälvadministrerat frågeformulär: papper WOLF-UWOLF-U WOLF-UWOLF-U Self-administered questionnaireSelf-administered questionnaire Självadministrerat frågeformulärSjälvadministrerat frågeformulär Access to data through an external actor. Access to data is restricted. Åtkomst till data via extern aktör. Tillgång till data är begränsad. restrictedAccess Tsutsumi A, Iwata N, Watanabe N, de Jonge J, Pikhart H, Fernández-López JA, Xu L, Peter R, Knutsson A, Niedhammer I, Kawakami N, Siegrist J. Application of item response theory to achieve cross- cultural comparability of occupational stress measurement. Int J Methods Psychiatr Res. 2009 Feb 4;18(1):58-67. Tsutsumi A, Iwata N, Watanabe N, de Jonge J, Pikhart H, Fernández-López JA, Xu L, Peter R, Knutsson A, Niedhammer I, Kawakami N, Siegrist J. Application of item response theory to achieve cross- cultural comparability of occupational stress measurement. Int J Methods Psychiatr Res. 2009 Feb 4;18(1):58-67. Nordin M, Knutsson A, Sundbom E, Åkerstedt T, Westerholm P, Alfredsson L. Low social support and vulnerability in the association with disturbed sleep. Longitudinal results from the WOLF study. Submitted to J Occup Health Psychology. 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Nyberg ST, Heikkilä K, Fransson EI, Alfredsson L, De Bacquer D, Bjorner JB, Bonenfant S, Borritz M, Burr H, Casini A, Clays E, Dragano N, Erbel R, Geuskens GA, Goldberg M, Hooftman WE, Houtman IL, Jöckel KH, Kittel F, Knutsson A, Koskenvuo M, Leineweber C, Lunau T, Madsen IEH, Magnusson Hanson LL, Marmot MG, Nielsen ML, Nordin M, Oksanen T, Pentti J, Rugulies R, Siegrist J, Suominen S, Vahtera J, Virtanen M, Westerholm P, Westerlund H, Zins M, Ferrie JE, Theorell T, Steptoe A, Hamer M, Singh-Man Nyberg ST, Heikkilä K, Fransson EI, Alfredsson L, De Bacquer D, Bjorner JB, Bonenfant S, Borritz M, Burr H, Casini A, Clays E, Dragano N, Erbel R, Geuskens GA, Goldberg M, Hooftman WE, Houtman IL, Jöckel KH, Kittel F, Knutsson A, Koskenvuo M, Leineweber C, Lunau T, Madsen IEH, Magnusson Hanson LL, Marmot MG, Nielsen ML, Nordin M, Oksanen T, Pentti J, Rugulies R, Siegrist J, Suominen S, Vahtera J, Virtanen M, Westerholm P, Westerlund H, Zins M, Ferrie JE, Theorell T, Steptoe A, Hamer M, Singh-Man Karlson B, Knutsson A, Lindahl B, Alfredsson L. 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