Effect of food intake on 92 biomarkers for cardiovascular disease
type: Dataset
description: Objective: The present study evaluates the effect of food intake on 92 biomarkers for cardiovascular disease (CVD). Methods: Twenty two healthy subjects (11 male and 11 female aged 25.9±4.2 years) were investigated. A total of 92 biomarkers were measured before a standardized meal as well as 30 and 120 minutes afterwards with the Proseek Multiplex CVD III kit. Results: The levels for eight biomarkers decreased significantly (P<0.05) 30 minutes after food intake. The levels for seven biomarkers remained significantly decreased 120 minutes after food intake. Nine biomarker decreased significantly at 120 minutes after food intake. The changes were between 4-30%, most commonly around 5%. Only six biomarkers showed a difference of 10% or more due to food intake. The biggest differences were observed for Insulin-like growth factor-binding protein 1 (30%); Azurocidin, Cystatin-B, and Myeloperoxidase (13%); Monocyte chemotactic protein 1 (11%); and Myeloblastin (10%), all 120 minutes after food intake. Conclusions: This study shows that food intake affects several different CVD biomarkers, but the effect is predominantly modest. Timing of blood sampling in relation to food intake, therefore, appears not to be a major concern. Further studies are warranted in older healthy subjects and in patients with various cardiac diseases to determine whether the findings are reproducible. Purpose: The present study evaluates the effect of food intake on 92 biomarkers for cardiovascular disease with the Proseek Multiplex CVD III kit.
citation: Dencker M. Effect of food intake on 92 biomarkers for cardiovascular disease. PONE-D-17-02534R1
conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
conditions of access: info:eu-repo/semantics/openAccess
creative work status: completed
  type: DefinedTerm
  in defined term set: http://publications.europa.eu/resource/authority/dataset-status
  term code: COMPLETED
creator: Magnus Dencker
  type: Person
  affiliation: Skåne University Hospital, Malmö, Lund University
  family name: Dencker
  given name: Magnus
date modified: 2017-06-09
date published: 2017-05-29
language: English
is part of: https://doi.org/10.5878/002890
keywords: HEALTH
keywords: Medical and Health Sciences
  type: DefinedTerm
  term code: 3
keywords: biomarkers
keywords: cardiovascular disease
keywords: food intake
publisher: Lund University
size: QuantitativeValue
  unit text: cases
  value: 22
size: QuantitativeValue
  unit text: variables
  value: 281
spatial coverage: Sweden
spatial coverage: Skåne County
temporal coverage: 2009-01/2009-09
distribution: data/1024-001-v1.zip
  type: DataDownload
  additional type: data
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 205311
  encoding format: application/zip
distribution: documentation/List of variables.pdf
  type: DataDownload
  additional type: documentation
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 721786
  encoding format: application/pdf
version: 1.0

PropertyValue
property ID: DOI
value: 10.5878/002891

English
type: Language
alternate name: eng

HEALTH
type: DefinedTerm
term code: Health

Lund University
type: Organization

Sweden
type: Place

Skåne County
type: Place