Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children
Cystatin B, cathepsin L och D relaterat till andra riskfaktorer för hjärt-och kärlsjukdom hos barn
Objective: This study investigated potential associations between novel biomarkers for cardiovascular disease and other surrogate markers for health. Methods: Community sample of 170 (92 boys and 78 girls) children aged 8-11 years. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for cystatin B, cathepsin L and cathepsin D. Results: Partial correlations between cystatin B versus lnTBF, lnBF%, lnAFM, AFM/TBF, VO2PEAK and PP were; r=0.38, 0.36, 0.38, 0.29, -0.25 and 0.25, P=0.001 or less for all. Weaker predominantly non-significant correlations were found for cathepsin L, whereas cathepsin D was not related to any surrogate markers for health. No significant correlations were found between biomarkers and change in body fat over 2 years. Conclusion: Findings from this community-based cohort of young children show that surrogate markers for cardiovascular disease such as total fat mass, percent body fat, abdominal fat, body fat distribution, maximal oxygen uptake and pulse pressure were all associated with cystatin B. This was not found for cathepsin L or cathepsin D. Purpose: This study investigated potential associations between novel biomarkers for cardiovascular disease (Cystatin B, cathepsin L and D9 and other surrogate markers for health. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for cystatin B, cathepsin L and cathepsin D.
Studien studerade relationen mellan traditionella och nya riskfaktorer för hjärt-och kärlsjukdom som Cystatin B, cathepsin L and D hos barn. Totalt studerade 170 bran i åldern 8-11 år. Cystatin B var svagt-måttligt relaterat till kropps fett och kondition medan cathepsin L and D inte var det. Syfte: Studera relationen mellan traditionella och nya riskfaktorer för hjärt-och kärlsjukdom som Cystatin B, cathepsin L and D hos barn Följande mätningar är gjorda; Blodtryck, Fysisk prestationsförmåga, Ekokardiografi, DXA, Blodprov analyserade för cystatin B, cathepsin L och cathepsin D.
Risk Factors
Riskfaktorer
Child
Barn
Cardiovascular Diseases
Kardiovaskulära sjukdomar
Cathepsin D
Katepsin D
Skinfold Thickness
Kroppsfettsmätning
Cystatin B
Cathepsin L
Katepsin L
Landing page for the dataset
Landningssida för datasetet
Lund University
Lunds universitet
Sweden
Sverige
Skåne County
Skåne län