Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children
type: Dataset
distribution: Landing page for the dataset
title: Cystatin B, cathepsin L och D relaterat till andra riskfaktorer för hjärt-och kärlsjukdom hos barn @sv
description: Objective: This study investigated potential associations between novel biomarkers for cardiovascular disease and other surrogate markers for health. Methods: Community sample of 170 (92 boys and 78 girls) children aged 8-11 years. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for cystatin B, cathepsin L and cathepsin D. Results: Partial correlations between cystatin B versus lnTBF, lnBF%, lnAFM, AFM/TBF, VO2PEAK and PP were; r=0.38, 0.36, 0.38, 0.29, -0.25 and 0.25, P=0.001 or less for all. Weaker predominantly non-significant correlations were found for cathepsin L, whereas cathepsin D was not related to any surrogate markers for health. No significant correlations were found between biomarkers and change in body fat over 2 years. Conclusion: Findings from this community-based cohort of young children show that surrogate markers for cardiovascular disease such as total fat mass, percent body fat, abdominal fat, body fat distribution, maximal oxygen uptake and pulse pressure were all associated with cystatin B. This was not found for cathepsin L or cathepsin D. Purpose: This study investigated potential associations between novel biomarkers for cardiovascular disease (Cystatin B, cathepsin L and D9 and other surrogate markers for health. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM…
description: Studien studerade relationen mellan traditionella och nya riskfaktorer för hjärt-och kärlsjukdom som Cystatin B, cathepsin L and D hos barn. Totalt studerade 170 bran i åldern 8-11 år. Cystatin B var svagt-måttligt relaterat till kropps fett och kondition medan cathepsin L and D inte var det. Syfte: Studera relationen mellan traditionella och nya riskfaktorer för hjärt-och kärlsjukdom som Cystatin B, cathepsin L and D hos barn Följande mätningar är gjorda; Blodtryck, Fysisk prestationsförmåga, Ekokardiografi, DXA, Blodprov analyserade för cystatin B, cathepsin L och cathepsin D. @sv
modified: 2017-10-09T11:11:53Z
issued: 2017-10-09T00:00:00Z
publisher: Lund University
theme: HEAL
access rights: PUBLIC
qualified attribution: Attribution
  had role: principalInvestigator
  agent: Magnus Dencker
    type: Agent
    type: PrivateIndividual(s)
keyword: Risk Factors
keyword: Riskfaktorer @sv
keyword: Child
keyword: Barn @sv
keyword: Cardiovascular Diseases
keyword: Kardiovaskulära sjukdomar @sv
keyword: Cathepsin D
keyword: Katepsin D @sv
keyword: Skinfold Thickness
keyword: Kroppsfettsmätning @sv
keyword: Cystatin B
keyword: Cathepsin L
keyword: Katepsin L @sv
language: ENG
spatial: Sweden
spatial: Skåne County

Landing page for the dataset
type: Distribution
title: Landningssida för datasetet @sv
access URL: Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children
availability: stable

Lund University
type: Agent
name: Lunds universitet @sv
type: Academia-ScientificOrganisation
source: 012a77v79

Sweden
type: Location
label: Sverige @sv

Skåne County
type: Location
label: Skåne län @sv