Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children
type: Dataset
description: Objective: This study investigated potential associations between novel biomarkers for cardiovascular disease and other surrogate markers for health. Methods: Community sample of 170 (92 boys and 78 girls) children aged 8-11 years. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for cystatin B, cathepsin L and cathepsin D. Results: Partial correlations between cystatin B versus lnTBF, lnBF%, lnAFM, AFM/TBF, VO2PEAK and PP were; r=0.38, 0.36, 0.38, 0.29, -0.25 and 0.25, P=0.001 or less for all. Weaker predominantly non-significant correlations were found for cathepsin L, whereas cathepsin D was not related to any surrogate markers for health. No significant correlations were found between biomarkers and change in body fat over 2 years. Conclusion: Findings from this community-based cohort of young children show that surrogate markers for cardiovascular disease such as total fat mass, percent body fat, abdominal fat, body fat distribution, maximal oxygen uptake and pulse pressure were all associated with cystatin B. This was not found for cathepsin L or cathepsin D. Purpose: This study investigated potential associations between novel biomarkers for cardiovascular disease (Cystatin B, cathepsin L and D9 and other surrogate markers for health. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM…
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conditions of access: info:eu-repo/semantics/openAccess
creative work status: completed
  type: DefinedTerm
  in defined term set: http://publications.europa.eu/resource/authority/dataset-status
  term code: COMPLETED
creator: Magnus Dencker
  type: Person
  family name: Dencker
  given name: Magnus
date modified: 2017-10-09
date published: 2017-10-09
language: English
is part of: https://doi.org/10.5878/002920
keywords: DEMOGRAPHY (POPULATION, VITAL STATISTICS, AND CENSUSES)
keywords: Medical and Health Sciences
  type: DefinedTerm
  term code: 3
keywords: Risk Factors
keywords: Child
keywords: Cardiovascular Diseases
keywords: Cathepsin D
keywords: Skinfold Thickness
keywords: Cystatin B
keywords: Cathepsin L
publisher: Lund University
size: QuantitativeValue
  unit text: cases
  value: 248
size: QuantitativeValue
  unit text: variables
  value: 33
spatial coverage: Sweden
spatial coverage: Skåne County
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PropertyValue
property ID: DOI
value: 10.5878/002921

English
type: Language
alternate name: eng

DEMOGRAPHY (POPULATION, VITAL STATISTICS, AND CENSUSES)
type: DefinedTerm
term code: Demography

Risk Factors
type: DefinedTerm
description: An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent.
term code: D012307

Child
type: DefinedTerm
description: A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.
term code: D002648

Cardiovascular Diseases
type: DefinedTerm
description: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
term code: D002318

Cathepsin D
type: DefinedTerm
description: An intracellular proteinase found in a variety of tissue. It has specificity similar to but narrower than that of pepsin A. The enzyme is involved in catabolism of cartilage and connective tissue. EC 3.4.23.5. (Formerly EC 3.4.4.23).
term code: D002402

Skinfold Thickness
type: DefinedTerm
description: The measurement of subcutaneous fat located directly beneath the skin by grasping a fold of skin and subcutaneous fat between the thumb and forefinger and pulling it away from the underlying muscle tissue. The thickness of the double layer of skin and subcutaneous tissue is then read with a caliper. The five most frequently measured sites are the upper arm, below the scapula, above the hip bone, the abdomen, and the thigh. Its application is the determination of relative fatness, of changes in physical conditioning programs, and of the percentage of body fat in desirable body weight. (From McArdle, et al., Exercise Physiology, 2d ed, p496-8)
term code: D012885

Cystatin B
type: DefinedTerm
description: An intracellular cystatin subtype that is found in a broad variety of cell types. It is a cytosolic enzyme inhibitor that protects the cell against the proteolytic action of lysosomal enzymes such as CATHEPSINS.
term code: D055313

Cathepsin L
type: DefinedTerm
description: A ubiquitously-expressed cysteine protease that plays an enzymatic role in POST-TRANSLATIONAL PROTEIN PROCESSING of proteins within SECRETORY GRANULES.
term code: D056668

Lund University
type: Organization

Sweden
type: Place

Skåne County
type: Place