Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin
type: Dataset
distribution: Landing page for the dataset
description: We tested a larger number of organic solvents with the same experimental set up, using skin from new-born piglets and static diffusion cells. Thirty-six common organic solvents were studied neat (and 31 of them also in water dilution): acetone, acetonitrile, n-butanol 2-butanone 2-butoxyethanol, 1-butoxy-2-propanol, n-butyl acetate, butyl acrylate, cyclohexane, cyclohexanone, 1,2-dichloroethane, dichloromethane, ethanol, 2-ethoxyethanol, ethyl acetate, ethyl acrylate, ethylbenzene, furfuryl alcohol, n-hexane, 2-hexanone, 2-isopropoxyethanol, methanol, 1-methoxy-2-propanol, methyl acrylate, 3-methyl-1-butanol, methyl tertiary butyl ether, 4-metyl-2-pentanol, methyl methacrylate, 2-propanol, 2-propen-1-ol, 2-propoxyethanol, 1-propoxy-2-propanol, styrene, trichloromethane, toluene and m-xylene. Experiments for one substance(dilution) are reported in one worksheet. We report peak areas for the gas chromatographic analyses and the calculated skin permeation parameters for each experiment.
description: We tested a larger number of organic solvents with the same experimental set up, using skin from new-born piglets and static diffusion cells. Thirty-six common organic solvents were studied neat (and 31 of them also in water dilution): acetone, acetonitrile, n-butanol 2-butanone 2-butoxyethanol, 1-butoxy-2-propanol, n-butyl acetate, butyl acrylate, cyclohexane, cyclohexanone, 1,2-dichloroethane, dichloromethane, ethanol, 2-ethoxyethanol, ethyl acetate, ethyl acrylate, ethylbenzene, furfuryl alcohol, n-hexane, 2-hexanone, 2-isopropoxyethanol, methanol, 1-methoxy-2-propanol, methyl acrylate, 3-methyl-1-butanol, methyl tertiary butyl ether, 4-metyl-2-pentanol, methyl methacrylate, 2-propanol, 2-propen-1-ol, 2-propoxyethanol, 1-propoxy-2-propanol, styrene, trichloromethane, toluene and m-xylene. Experimentella data för varje ämne och spädning rapporteras i ett excelark. Toppareor från gaskromatografiska analyser och beräknade hudupptagsparametrar för varje enskild experiment rapporteras. @sv
modified: 2026-04-09T08:05:45.808898Z
issued: 2018-09-28T00:00:00Z
publisher: Karolinska Institutet
theme: HEAL
access rights: NON PUBLIC
qualified attribution: Attribution
  had role: principalInvestigator
  agent: Gunnar Johanson
    type: Agent
    account: https://orcid.org/0000-0002-8759-9567
    type: PrivateIndividual(s)
keyword: Franz cell
keyword: permeability coefficient
keyword: dermal penetration
keyword: diffusion coefficient
keyword: flux
temporal: PeriodOfTime
  start date: 2005-01-01
  end date: 2012-01-01
language: ENG

Landing page for the dataset
type: Distribution
title: Landningssida för datasetet @sv
access URL: Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin
availability: stable

Karolinska Institutet
type: Agent
type: Academia-ScientificOrganisation
source: https://ror.org/056d84691