<codeBook xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xsi:schemaLocation="ddi:codebook:2_5 http://www.ddialliance.org/Specification/DDI-Codebook/2.5/XMLSchema/codebook.xsd" xmlns="ddi:codebook:2_5">
  <docDscr>
    <citation>
      <titlStmt>
        <titl xml:lang="sv">Matrix Metalloproteinases vid kronisk obstruktiv lungsjukdom och åderförkalkning</titl>
        <parTitl xml:lang="en">Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking</parTitl>
        <IDNo agency="SND">snd1084-1-1.0</IDNo>
        <IDNo agency="DOI">https://doi.org/10.5878/eybp-ex91</IDNo>
      </titlStmt>
      <prodStmt>
        <producer xml:lang="en" abbr="SND">Swedish National Data Service</producer>
        <producer xml:lang="sv" abbr="SND">Svensk nationell datatjänst</producer>
      </prodStmt>
      <holdings URI="https://doi.org/10.5878/eybp-ex91">Landing page</holdings>
    </citation>
  </docDscr>
  <stdyDscr>
    <citation>
      <titlStmt>
        <titl xml:lang="sv">Matrix Metalloproteinases vid kronisk obstruktiv lungsjukdom och åderförkalkning</titl>
        <parTitl xml:lang="en">Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking</parTitl>
        <IDNo agency="SND">snd1084-1-1.0</IDNo>
        <IDNo agency="DOI">https://doi.org/10.5878/eybp-ex91</IDNo>
        <IDNo agency="DOI">10.1371/journal.pone.0211987</IDNo>
      </titlStmt>
      <rspStmt>
        <AuthEnty xml:lang="en" affiliation="Lund University and Region Skåne">Kraen, Morten</AuthEnty>
        <AuthEnty xml:lang="sv" affiliation="Lunds universitet och Region Skåne">Kraen, Morten</AuthEnty>
      </rspStmt>
      <prodStmt />
      <distStmt>
        <distrbtr xml:lang="en" abbr="SND" URI="https://snd.se">Swedish National Data Service</distrbtr>
        <distrbtr xml:lang="sv" abbr="SND" URI="https://snd.se">Svensk nationell datatjänst</distrbtr>
        <distDate xml:lang="en" date="2019-02-06" />
      </distStmt>
      <verStmt>
        <version elementVersion="1.0" elementVersionDate="2019-02-06" />
      </verStmt>
      <holdings URI="https://doi.org/10.5878/eybp-ex91">Landing page</holdings>
    </citation>
    <stdyInfo>
      <subject>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D050197">Atherosclerosis</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D050197">Ateroskleros</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D029424">Pulmonary Disease, Chronic Obstructive</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D029424">Kroniskt obstruktiv lungsjukdom</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D019278">Matrix Metalloproteinase 3</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D019278">Matrixmetalloproteinas 3</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D020781">Matrix Metalloproteinase 1</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D020781">Matrixmetalloproteinas 1</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D020783">Matrix Metalloproteinase 7</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D020783">Matrixmetalloproteinas 7</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D053506">Matrix Metalloproteinase 10</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D053506">Matrixmetalloproteinas 10</keyword>
        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D053508">Matrix Metalloproteinase 12</keyword>
        <keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D053508">Matrixmetalloproteinas 12</keyword>
      </subject>
      <abstract xml:lang="en" contentType="abstract">Matrix metalloproteinases (MMP´s) are known biomarkers of atherosclerosis. MMP´s are also involved in the pathophysiological processes underlying chronic obstructive pulmonary disease (COPD).  Cigarette smoking plays an important role in both disease states and is also known to affect the concentration and activity of MMP´s systemically. Unfortunately, the epidemiological data concerning the value of MMP´s as biomarkers of COPD and atherosclerosis with special regards to smoking habits are limited. Methods:  417  subjects with records of smoking habits and tobacco consumption were examined with comprehensive spirometry, carotid ultrasound examination and biomarker analysis of MMP-1, -3, -7, -10 and   -12</abstract>
      <abstract xml:lang="sv" contentType="abstract">Mätning av blodnivå av Matrix Metalloproteinases vid kronisk obstruktiv lungsjukdom och åderförkalkning och rökning.</abstract>
      <sumDscr>
        <dataKind xml:lang="en">Numeric</dataKind>
      </sumDscr>
    </stdyInfo>
    <method>
      <dataColl />
    </method>
    <dataAccs>
      <useStmt>
        <restrctn xml:lang="en">Access to data through SND. Data are freely accessible.</restrctn>
        <restrctn xml:lang="sv">Åtkomst till data via SND. Data är fritt tillgängliga.</restrctn>
        <conditions elementVersion="info:eu-repo-Access-Terms vocabulary">openAccess</conditions>
      </useStmt>
    </dataAccs>
    <othrStdyMat>
      <relPubl>
        <citation>
          <titlStmt>
            <titl xml:lang="sv">Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking
M. Kraen, S. Frantz, U. Nihlén, G. Engström, C. G. Löfdahl, P. Wollmer &amp; M. Dencker, 2019 Feb 21, In : PLoS ONE. 14, 2, e0211987.</titl>
            <parTitl xml:lang="en">Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking
M. Kraen, S. Frantz, U. Nihlén, G. Engström, C. G. Löfdahl, P. Wollmer &amp; M. Dencker, 2019 Feb 21, In : PLoS ONE. 14, 2, e0211987.</parTitl>
            <IDNo agency="DOI">10.1371/journal.pone.0211987</IDNo>
          </titlStmt>
          <distStmt>
            <distDate date="2019">2019</distDate>
          </distStmt>
        </citation>
      </relPubl>
    </othrStdyMat>
  </stdyDscr>
</codeBook>