<ddi:DDIInstance xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="ddi:instance:3_3 http://ddialliance.org/Specification/DDI-Lifecycle/3.3/XMLSchema/instance.xsd" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:ddi="ddi:instance:3_3" xmlns:r="ddi:reusable:3_3" xmlns:s="ddi:studyunit:3_3" xmlns:d="ddi:datacollection:3_3" xmlns:a="ddi:archive:3_3" xmlns:c="ddi:conceptualcomponent:3_3" xmlns:cm="ddi:comparative:3_3" xmlns:g="ddi:group:3_3" xmlns:l="ddi:logicalproduct:3_3" xmlns:p="ddi:physicaldataproduct:3_3" xmlns:pi="ddi:physicalinstance:3_3" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xhtml="http://www.w3.org/1999/xhtml" xmlns:xml="http://www.w3.org/XML/1998/namespace" isMaintainable="true" scopeOfUniqueness="Agency">
  <r:URN>urn:ddi:se.researchdata:snd1084-1:1.0</r:URN>
  <r:Agency>SND</r:Agency>
  <r:ID>snd1084-1</r:ID>
  <r:Version>1.0</r:Version>
  <g:ResourcePackage>
    <r:URN>urn:ddi:se.researchdata:snd1084-1.ResourcePackage:2.0</r:URN>
    <r:OtherMaterialScheme>
      <r:URN>urn:ddi:se.researchdata:snd1084-1.OtherMaterialScheme:2.0</r:URN>
    </r:OtherMaterialScheme>
    <a:OrganizationScheme>
      <r:URN>urn:ddi:se.researchdata:snd1084-1.OrganizationScheme-0:2.0</r:URN>
      <a:Individual>
        <r:URN>urn:ddi:se.researchdata:snd1084-1.Individual-0:2.0</r:URN>
        <r:UserAttributePair>
          <r:AttributeKey>affiliation</r:AttributeKey>
          <r:AttributeValue>Lund University and Region Skåne</r:AttributeValue>
        </r:UserAttributePair>
        <a:IndividualIdentification>
          <a:IndividualName>
            <a:FirstGiven>Morten</a:FirstGiven>
            <a:LastFamily>Kraen</a:LastFamily>
            <a:FullName>
              <r:String>Morten Kraen</r:String>
            </a:FullName>
          </a:IndividualName>
        </a:IndividualIdentification>
      </a:Individual>
    </a:OrganizationScheme>
  </g:ResourcePackage>
  <s:StudyUnit>
    <r:URN>urn:ddi:se.researchdata:snd1084-1.StudyUnit:2.0</r:URN>
    <r:UserID typeOfUserID="datasetIdentifier">snd1084-1</r:UserID>
    <r:Citation>
      <r:Title>
        <r:String xml:lang="sv">Matrix Metalloproteinases vid kronisk obstruktiv lungsjukdom och åderförkalkning</r:String>
        <r:String xml:lang="en">Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking</r:String>
      </r:Title>
      <r:Creator>
        <r:CreatorReference>
          <r:URN>urn:ddi:se.researchdata:snd1084-1.Individual-0:2.0</r:URN>
          <r:TypeOfObject>Individual</r:TypeOfObject>
        </r:CreatorReference>
      </r:Creator>
      <r:Publisher>
        <r:PublisherName>
          <r:String xml:lang="sv">Lunds universitet</r:String>
          <r:String xml:lang="en">Lund University</r:String>
        </r:PublisherName>
      </r:Publisher>
      <r:Publisher>
        <r:PublisherName>
          <r:String xml:lang="sv">Lunds universitet</r:String>
          <r:String xml:lang="en">Lund University</r:String>
        </r:PublisherName>
      </r:Publisher>
      <r:PublicationDate>
        <r:SimpleDate>2019-02-06</r:SimpleDate>
      </r:PublicationDate>
      <r:InternationalIdentifier>
        <r:IdentifierContent>10.5878/eybp-ex91</r:IdentifierContent>
        <r:ManagingAgency controlledVocabularyAgencyName="DOI">DOI</r:ManagingAgency>
      </r:InternationalIdentifier>
    </r:Citation>
    <r:Abstract>
      <r:Content xml:lang="sv">Mätning av blodnivå av Matrix Metalloproteinases vid kronisk obstruktiv lungsjukdom och åderförkalkning och rökning.</r:Content>
      <r:Content xml:lang="en">Matrix metalloproteinases (MMP´s) are known biomarkers of atherosclerosis. MMP´s are also involved in the pathophysiological processes underlying chronic obstructive pulmonary disease (COPD).  Cigarette smoking plays an important role in both disease states and is also known to affect the concentration and activity of MMP´s systemically. Unfortunately, the epidemiological data concerning the value of MMP´s as biomarkers of COPD and atherosclerosis with special regards to smoking habits are limited. Methods:  417  subjects with records of smoking habits and tobacco consumption were examined with comprehensive spirometry, carotid ultrasound examination and biomarker analysis of MMP-1, -3, -7, -10 and   -12</r:Content>
    </r:Abstract>
    <r:Coverage>
      <r:TopicalCoverage>
        <r:URN>urn:ddi:se.researchdata:snd1084-1.TopicalCoverage:2.0</r:URN>
        <r:Subject xml:lang="en" controlledVocabularyID="302" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Clinical Medicine</r:Subject>
        <r:Subject xml:lang="sv" controlledVocabularyID="302" controlledVocabularyName="Standard för svensk indelning av forskningsämnen 2025">Klinisk medicin</r:Subject>
        <r:Keyword xml:lang="en" controlledVocabularyID="D050197" controlledVocabularyName="MeSH">Atherosclerosis</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="D050197" controlledVocabularyName="MeSH">Ateroskleros</r:Keyword>
        <r:Keyword xml:lang="en" controlledVocabularyID="D029424" controlledVocabularyName="MeSH">Pulmonary Disease, Chronic Obstructive</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="D029424" controlledVocabularyName="MeSH">Kroniskt obstruktiv lungsjukdom</r:Keyword>
        <r:Keyword xml:lang="en" controlledVocabularyID="D019278" controlledVocabularyName="MeSH">Matrix Metalloproteinase 3</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="D019278" controlledVocabularyName="MeSH">Matrixmetalloproteinas 3</r:Keyword>
        <r:Keyword xml:lang="en" controlledVocabularyID="D020781" controlledVocabularyName="MeSH">Matrix Metalloproteinase 1</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="D020781" controlledVocabularyName="MeSH">Matrixmetalloproteinas 1</r:Keyword>
        <r:Keyword xml:lang="en" controlledVocabularyID="D020783" controlledVocabularyName="MeSH">Matrix Metalloproteinase 7</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="D020783" controlledVocabularyName="MeSH">Matrixmetalloproteinas 7</r:Keyword>
        <r:Keyword xml:lang="en" controlledVocabularyID="D053506" controlledVocabularyName="MeSH">Matrix Metalloproteinase 10</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="D053506" controlledVocabularyName="MeSH">Matrixmetalloproteinas 10</r:Keyword>
        <r:Keyword xml:lang="en" controlledVocabularyID="D053508" controlledVocabularyName="MeSH">Matrix Metalloproteinase 12</r:Keyword>
        <r:Keyword xml:lang="sv" controlledVocabularyID="D053508" controlledVocabularyName="MeSH">Matrixmetalloproteinas 12</r:Keyword>
      </r:TopicalCoverage>
      <r:SpatialCoverage />
    </r:Coverage>
    <a:Archive>
      <r:URN>urn:ddi:se.researchdata:snd1084-1.Archive:2.0</r:URN>
      <a:ArchiveSpecific>
        <a:Item>
          <a:Access>
            <r:URN>urn:ddi:se.researchdata:snd1084-1.Archive-ArchiveSpecificType-AccessType:2.0</r:URN>
            <a:TypeOfAccess controlledVocabularyName="info:eu-repo-Access-Terms vocabulary">openAccess</a:TypeOfAccess>
          </a:Access>
          <a:DataFileQuantity>1</a:DataFileQuantity>
        </a:Item>
      </a:ArchiveSpecific>
    </a:Archive>
  </s:StudyUnit>
</ddi:DDIInstance>