Data showing how Repeated Lumbar Punctures within 3 days may affect CSF Biomarker Levels
type: Dataset
description: As an extension of a study on the relationship between sleep deprivation and cerebrospinal fluid (CSF) biomarkers for Alzheimer’s disease, we performed two Lumbar punctures (LPs) within three days in 13 healthy volunteers (N=13). Our aim was to investigate CSF biomarker dynamics in relation to sleep deprivation. An unexpected sharp rise in biomarker concentrations in the second sample made us consider an artifact and we therefore repeated the experiment, but without sleep restriction, in four additional individuals (N=4). A similar rise in biomarker levels were evident, suggesting an inherent methodological problem with repeated LPs. Experiment 1: Repeated lumbar punctures within 3 days without sleep intervention. Participants with controled normal sleep. Biomarker concentrations from each individual lumbar puncture. Experiment 2: After sleep deprivation and 3 days later, after recovery sleep. Biomarker concentrations from each individual lumbar puncture. First puncture immediately after sleep deprivation. Second puncture three days later, after recovery sleep.
citation: Olsson M, Arlig J, Hedner J, Blennow K, Zetterberg H. Sleep deprivation and cerebrospinal fluid biomarkers for Alzheimer's disease. Sleep. 2018;41(5). https://doi.org/10.1093/sleep/zsy025
citation: Olsson, M., Ärlig, J., Hedner, J. et al. Repeated lumbar punctures within 3 days may affect CSF biomarker levels. Fluids Barriers CNS 16, 37 (2019) doi:10.1186/s12987-019-0157-2
conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
conditions of access: info:eu-repo/semantics/openAccess
creative work status: completed
  type: DefinedTerm
  in defined term set: http://publications.europa.eu/resource/authority/dataset-status
  term code: COMPLETED
creator: Martin Olsson
creator: Johan Ärlig
  type: Person
  affiliation: University of Gothenburg
  family name: Ärlig
  given name: Johan
creator: Jan Hedner
  type: Person
  affiliation: University of Gothenburg
  family name: Hedner
  given name: Jan
creator: Kaj Blennow
  type: Person
  affiliation: University of Gothenburg
  family name: Blennow
  given name: Kaj
creator: Henrik Zetterberg
  type: Person
  affiliation: University of Gothenburg
  family name: Zetterberg
  given name: Henrik
date modified: 2024-08-08
date published: 2024-08-08
language: English
is part of: https://doi.org/10.5878/1esp-8265
keywords: Medical and Health Sciences
  type: DefinedTerm
  term code: 3
keywords: Cerebrospinal Fluid
keywords: Cerebrospinal Fluid Proteins
keywords: Amyloid beta-Peptides
keywords: CSF
keywords: tau
keywords: lumbar puncture
keywords: cerebrospinal fluid proteins
publisher: University of Gothenburg
size: QuantitativeValue
  unit text: cases
  value: 17
size: QuantitativeValue
  unit text: variables
  value: 8
temporal coverage: 2015-02-01/2016-02-29
distribution: data/Recovery sleep LP biomarker data.xlsx
  type: DataDownload
  additional type: data
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 13848
  encoding format: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
distribution: data/Repeated LP biomarker data.xlsx
  type: DataDownload
  additional type: data
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 11006
  encoding format: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
distribution: documentation/readme.txt
  type: DataDownload
  additional type: documentation
  conditions of access: http://publications.europa.eu/resource/authority/access-right/PUBLIC
  conditions of access: info:eu-repo/semantics/openAccess
  content size: 439
  encoding format: text/plain
version: 2

PropertyValue
property ID: DOI
value: 10.5878/14p1-3w07

PropertyValue
property ID: DOI
value: 10.1093/sleep/zsy025

PropertyValue
property ID: DOI
value: 10.1186/s12987-019-0157-2

Martin Olsson
type: Person
affiliation: University of Gothenburg
family name: Olsson
given name: Martin

University of Gothenburg
type: Organization
department: the Institute of Medicine
department: Institute of Neuroscience and Physiology

English
type: Language
alternate name: eng

Cerebrospinal Fluid
type: DefinedTerm
description: A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.
term code: D002555

Cerebrospinal Fluid Proteins
type: DefinedTerm
description: Proteins in the cerebrospinal fluid, normally albumin and globulin present in the ratio of 8 to 1. Increases in protein levels are of diagnostic value in neurological diseases. (Brain and Bannister's Clinical Neurology, 7th ed, p221)
term code: D002556

Amyloid beta-Peptides
type: DefinedTerm
description: Peptides generated from AMYLOID BETA-PEPTIDES PRECURSOR. An amyloid fibrillar form of these peptides is the major component of amyloid plaques found in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The peptide is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.
term code: D016229