NorthPop – Barns hälsa i Västerbotten NorthPop: a prospective population-based birth cohort study snd1239-1-1 Swedish National Data Service Svensk nationell datatjänst NorthPop – Barns hälsa i Västerbotten NorthPop: a prospective population-based birth cohort study snd1239-1-1 oai:DiVA.org:umu-243534 urn:nbn:se:umu:diva-243534 10.1111/apa.70266 oai:DiVA.org:umu-225931 10.1111/acel.14194 urn:nbn:se:umu:diva-225931 oai:DiVA.org:umu-209775 10.3390/nu15112565 oai:DiVA.org:umu-242444 10.1111/pai.70148 urn:nbn:se:umu:diva-242444 oai:DiVA.org:umu-239103 10.1186/s13148-025-01858-4 urn:nbn:se:umu:diva-239103 oai:DiVA.org:umu-235075 10.1111/pai.70035 urn:nbn:se:umu:diva-235075 oai:DiVA.org:umu-233047 10.1371/journal.pone.0316747 urn:nbn:se:umu:diva-233047 oai:DiVA.org:umu-216206 urn:nbn:se:umu:diva-216206 10.1016/j.jaci.2023.08.037 oai:DiVA.org:umu-181575 urn:nbn:se:umu:diva-181575 10.1186/s12884-021-03627-6 oai:DiVA.org:oru-111020 urn:nbn:se:oru:diva-111020 10.1016/j.envint.2024.108440 oai:DiVA.org:umu-185572 10.3390/nu13072265 urn:nbn:se:umu:diva-185572 oai:DiVA.org:umu-200109 10.1111/pai.13848 oai:DiVA.org:umu-210213 10.1111/cea.14346 oai:DiVA.org:umu-234871 urn:nbn:se:umu:diva-234871 10.1016/j.jaci.2024.12.1080 oai:DiVA.org:umu-241898 urn:nbn:se:umu:diva-241898 10.1186/s12889-025-23561-y oai:DiVA.org:umu-216664 10.3390/nu15204318 urn:nbn:se:umu:diva-216664 Domellöf, Magnus Domellöf, Magnus West, Christina West, Christina Child and Adolescent Medical Center, Region Västerbotten Barn- och ungdomscentrum, Region Västerbotten Swedish National Data Service Svensk nationell datatjänst HEALTH HÄLSA CHILDREN BARN SLEEP SÖMN Cohort Studies Kohortstudier Dental Caries Karies Life Style Livsstil Risk Factors Riskfaktorer Overweight Övervikt Diet Kost Asthma Astma Child Barn Public Health Folkhälsa Pregnancy Graviditet OBSTETRICS OBSTETRIK ALLERGIES ALLERGIER Child Nutrition Sciences Barnnutrition Child Development Barns utveckling Energy Metabolism Energiomsättning Family Health Familjens hälsa Genetics, Medical Medicinsk genetik Infant Spädbarn Pediatrics Pediatrik Pregnancy Outcome Graviditetsutfall Actigraphy Aktigrafi Epigenomics Epigenomik Cognitive Dysfunction Kognitiv dysfunktion Accelerometry Accelerometri Microbiota Mikrobiota Noncommunicable Diseases Icke smittsamma sjukdomar GROWTH (PHYSIOLOGY) TILLVÄXT (FYSIOLOGISK) NorthPop is a research infrastructure at Region Västerbotten and Umeå University. It consists of a database and biobank containing extensive population-based, longitudinal data. These are collected from 30 000 individuals, which include 10 000 children and also their parents, who are 32 years of age on average at time of delivery. Region Västerbotten and Umeå University have a successful tradition of research based on databases and biobanks, but previously they were almost entirely focused on middle-aged and older individuals, or specific diseases. There is a great need for of a population-based infrastructure with a biobank for children and young adults, as the majority of our lifestyle-related diseases and behaviors are established early in life. Children and young adults account for 50% (130 000 individuals) of the population in Västerbotten. NorthPop therefore perfectly complements the Västerbotten Health Surveys (VHU), which cover the ages of 40 years and older, enabling completely new multi-generational research projects. Data collection consists of: 1. Questionnaires: During pregnancy, three questionnaires are answered by the each parent. A series of questionnaires are then sent out when the child is 4 months, 9 months, 18 months, 2 years, 3 years and 7 years old. 2. Samples: Biological samples are collected from the women during pregnancy, in gestational weeks 14-24, around gestational week 28, and 1 month postpartum. The children are sampled at birth, 48 hours postpartum, at 1, 9, 18 months as well as 3 and 7 years of age. Meconium, feces, oral swabs and breast milk are sampled either by the parents at home or at the hospital. - Urine: A 10 mL urine sample is collected from the mothers at the routine ultrasound examination, in gestational weeks 14-24. - Blood: Venous blood samples from the women at gestational week 28, at birth from the umbilical cord and from the children at 18 months and 7 years of age. - Meconium. Oral swabs: Parents collect oral swabs from the children at 48 hours postpartum, 1, 9, 18 months and at 3 and 7 years of age. - Feces: The parents collect fecal samples at home, at 1, 9, 18 months and at 3 and 7 years of age. - Breast milk: When the infant is 1 month old, breast milk is sampled at home at the first feeding in the morning. 3. Additional Measurements Actigraphy (Physical activity, light exposure, and sleep patterns) in a sub-cohort at 3 and 7 years of age. At age 7: Blood pressure, pulse, skin prick test, hand grip strength, height, weight, working memory. 4. Additional registers: Child health care records Dental records Maternity care center records School health care records The Longitudinal Integrated Database for Health Insurance and Labour Market Studies (LISA) The National Patient Register The National Prescribed Drug Register The Swedish Child Health Services registry (BHVQ) The Swedish Geographical Database The Swedish Neonatal Quality Register (SNQ) The Swedish Pregnancy Register The Swedish Quality Register for Caries and Periodontitis (SKaPa) The Swedish School Health Care Quality Register (EMQ) The Total Population Register NorthPop är en forskningsinfrastruktur vid Region Västerbotten och Umeå universitet. Den består av en databas och biobank som innehåller omfattande populationsbaserade, longitudinella data. Dessa samlas in från 30 000 individer, vilket inkluderar 10 000 barn och deras föräldrar, som i genomsnitt är 32 år gamla vid förlossningen. Region Västerbotten och Umeå universitet har en framgångsrik tradition av forskning baserad på databaser och biobanker, men tidigare har fokus nästan helt legat på medelålders och äldre individer eller specifika sjukdomar. Det finns ett stort behov av en befolkningsbaserad infrastruktur med en biobank för barn och unga vuxna, eftersom majoriteten av våra livsstilsrelaterade sjukdomar och beteenden etableras tidigt i livet. Barn och unga vuxna utgör 50% (130 000 individer) av befolkningen i Västerbotten. NorthPop kompletterar därför perfekt Västerbottens hälsoundersökningar (VHU), som täcker åldrarna 40 år och uppåt, och möjliggör helt nya fler-generations forskningsprojekt. Datainsamlingen består av: 1. Enkäter: Under graviditeten besvarar föräldrarna tre enkäter var. Enkäter skickas sedan ut när barnet är 4 månader, 9 månader, 18 månader, 2 år, 3 år och 7 år gammalt. 2. Provtagning: Biologiska prover samlas in från kvinnorna under graviditeten, i graviditetsveckorna 14-24, runt graviditetsvecka 28 och 1 månad efter förlossningen. Barnen provtas vid födseln, 48 timmar efter födseln, vid 1, 9, 18 månader samt vid 3 och 7 års ålder. Mekonium, avföring, munsvabb och bröstmjölk samlas antingen in av föräldrarna hemma eller på sjukhuset. - Urin: Ett urinprov på 10 ml samlas in från mödrarna vid det rutinmässiga ultraljudet, i graviditetsveckorna 14-24. - Blod: Venösa blodprover tas från kvinnorna i graviditetsvecka 28, från navelsträngen vid födseln och från barnen vid 18 månader och 7 års ålder. - Mekonium. - Munsvabb: Föräldrarna samlar in munsvabb från barnen 48 timmar efter födseln, vid 1, 9, 18 månader samt vid 3 och 7 års ålder. - Avföring: Föräldrarna samlar in avföringsprover hemma, vid 1, 9, 18 månader samt vid 3 och 7 års ålder. - Bröstmjölk: När barnet är 1 månad gammalt samlas bröstmjölk in hemma vid dagens första matning. 3. Ytterligare mätningar Aktigrafi (fysisk aktivitet, ljusexponering och sömnmönster) i en sub-kohort vid 3 och 7 års ålder. Vid 7 års ålder: Blodtryck, puls, pricktest, handgreppstyrka, längd, vikt, arbetsminne och tejp-prov på huden. 4. Ytterligare register: Barnhälsovårdsjournaler Tandvårdsjournaler Mödravårdsjournaler Elevhälsovårdsjournaler Longitudinell integrationsdatabas för sjukförsäkrings- och arbetsmarknadsstudier (LISA) Patientregistret Läkemedelsregistret Svenska barnhälsovårdsregistret (BHVQ) Svenska geografiska databasen Svenska neonatal kvalitetsregistret (SNQ) Graviditetsregistret Svenska kvalitetsregistret för karies och parodontit (SKaPa) Svenska skolhälsovårdens kvalitetsregister (EMQ) Befolkningsregistret (RTB) 2016 Sweden Sverige HouseholdHousehold HushållHushåll IndividualIndividual IndividIndivid FamilyFamily FamiljFamilj Housing unitHousing unit BostadsenhetBostadsenhet OtherOther ÖvrigtÖvrigt Pregnant women in Västerbotten county (and their partners) as well as their child/children with follow-up until the child/children are 7 years old. Gravida kvinnor i Västerbotten (och deras partners) samt deras barn som följs till 7 års ålder. Numeric Text Audio Other Longitudinal: Cohort/Event-basedLongitudinal: Cohort/Event-based Longitudinell: Kohort/HändelsebaseradLongitudinell: Kohort/Händelsebaserad Total universe/Complete enumerationTotal universe/Complete enumeration Hela populationen/total räkningHela populationen/total räkning Self-administered questionnaireSelf-administered questionnaire Självadministrerat frågeformulärSjälvadministrerat frågeformulär Access to data through an external actor. Access to data is restricted. Åtkomst till data via extern aktör. Tillgång till data är begränsad. restrictedAccess Backman, E., Lundberg Ulfsdotter, R., Silfverdal, S.-A., West, C. E., & Domellöf, M. (2025). Effects of the COVID-19 lockdowns on gross motor and fine motor neurodevelopment in toddlers. In Acta Paediatrica. https://doi.org/10.1111/apa.70266 Backman, E., Lundberg Ulfsdotter, R., Silfverdal, S.-A., West, C. E., & Domellöf, M. (2025). Effects of the COVID-19 lockdowns on gross motor and fine motor neurodevelopment in toddlers. In Acta Paediatrica. https://doi.org/10.1111/apa.70266 urn:nbn:se:umu:diva-243534 10.1111/apa.70266 oai:DiVA.org:umu-243534 2025 oai:DiVA.org:umu-243534 Yeung, E., Biedrzycki, R. J., Gómez Herrera, L. C., Issarapu, P., Dou, J., Marques, I. F., Mansuri, S. R., Page, C. M., Harbs, J., Khodasevich, D., Poisel, E., Niu, Z., Allard, C., Casey, E., Berstein, F. M., Mancano, G., Elliott, H. R., Richmond, R., He, Y., … Guan, W. (2024). Maternal age is related to offspring DNA methylation : a meta-analysis of results from the pace consortium. In Aging Cell (No. e14194; Vol. 23, Issue 8). https://doi.org/10.1111/acel.14194 Yeung, E., Biedrzycki, R. J., Gómez Herrera, L. C., Issarapu, P., Dou, J., Marques, I. F., Mansuri, S. R., Page, C. M., Harbs, J., Khodasevich, D., Poisel, E., Niu, Z., Allard, C., Casey, E., Berstein, F. M., Mancano, G., Elliott, H. R., Richmond, R., He, Y., … Guan, W. (2024). Maternal age is related to offspring DNA methylation : a meta-analysis of results from the pace consortium. In Aging Cell (No. e14194; Vol. 23, Issue 8). https://doi.org/10.1111/acel.14194 10.1111/acel.14194 urn:nbn:se:umu:diva-225931 oai:DiVA.org:umu-225931 2024 oai:DiVA.org:umu-225931 Lif Holgerson, P., Hasslöf, P., Esberg, A., Haworth, S., Domellöf, M., West, C. E., & Johansson, I. (2023). Genetic preference for sweet taste in mothers associates with mother-child preference and intake. In Nutrients (No. 2565; Vol. 15, Issue 11). https://doi.org/10.3390/nu15112565 Lif Holgerson, P., Hasslöf, P., Esberg, A., Haworth, S., Domellöf, M., West, C. E., & Johansson, I. (2023). Genetic preference for sweet taste in mothers associates with mother-child preference and intake. In Nutrients (No. 2565; Vol. 15, Issue 11). https://doi.org/10.3390/nu15112565 10.3390/nu15112565 oai:DiVA.org:umu-209775 2023 oai:DiVA.org:umu-209775 Österlund, J., Bodén, S., Granåsen, G., Lundberg Ulfsdotter, R., Domellöf, M., Winberg, A., Johansson, I., & West, C. E. (2025). Maternal dietary inflammatory index during pregnancy and the risk of offspring allergic disease. In Pediatric Allergy and Immunology (No. e70148; Vol. 36, Issue 7). https://doi.org/10.1111/pai.70148 Österlund, J., Bodén, S., Granåsen, G., Lundberg Ulfsdotter, R., Domellöf, M., Winberg, A., Johansson, I., & West, C. E. (2025). Maternal dietary inflammatory index during pregnancy and the risk of offspring allergic disease. In Pediatric Allergy and Immunology (No. e70148; Vol. 36, Issue 7). https://doi.org/10.1111/pai.70148 10.1111/pai.70148 urn:nbn:se:umu:diva-242444 oai:DiVA.org:umu-242444 2025 oai:DiVA.org:umu-242444 Pedersen, C.-E. T., Hoang, T. T., Jin, J., Starnawska, A., Granell, R., Elliott, H. R., Huels, A., Zar, H. J., Stein, D. J., Zhang, Y., Dekker, H. T. den, Duijts, L., Felix, J. F., Sangüesa, J., Bustamante, M., Casas, M., Vrijheid, M., Kadalayil, L., Rezwan, F. I., … Bønnelykke, K. (2025). Maternal asthma and newborn DNA methylation. In Clinical Epigenetics (No. 79; Vol. 17, Issue 1). https://doi.org/10.1186/s13148-025-01858-4 Pedersen, C.-E. T., Hoang, T. T., Jin, J., Starnawska, A., Granell, R., Elliott, H. R., Huels, A., Zar, H. J., Stein, D. J., Zhang, Y., Dekker, H. T. den, Duijts, L., Felix, J. F., Sangüesa, J., Bustamante, M., Casas, M., Vrijheid, M., Kadalayil, L., Rezwan, F. I., … Bønnelykke, K. (2025). Maternal asthma and newborn DNA methylation. In Clinical Epigenetics (No. 79; Vol. 17, Issue 1). https://doi.org/10.1186/s13148-025-01858-4 10.1186/s13148-025-01858-4 urn:nbn:se:umu:diva-239103 oai:DiVA.org:umu-239103 2025 oai:DiVA.org:umu-239103 Bodén, S., Lindam, A., Venter, C., Lundberg Ulfsdotter, R., Domellöf, M., & West, C. E. (2025). Diversity of complementary diet and early food allergy risk. In Pediatric Allergy and Immunology (No. e70035; Vol. 36, Issue 1). https://doi.org/10.1111/pai.70035 Bodén, S., Lindam, A., Venter, C., Lundberg Ulfsdotter, R., Domellöf, M., & West, C. E. (2025). Diversity of complementary diet and early food allergy risk. In Pediatric Allergy and Immunology (No. e70035; Vol. 36, Issue 1). https://doi.org/10.1111/pai.70035 10.1111/pai.70035 urn:nbn:se:umu:diva-235075 oai:DiVA.org:umu-235075 2025 oai:DiVA.org:umu-235075 Jansson, D., Westlander, R., Sandlund, J., West, C. E., Domellöf, M., & Wulff, K. (2025). Behaviour-based movement cut-off points in 3-year old children comparing wrist- with hip-worn actigraphs MW8 and GT3X. In PLOS ONE (No. e0316747; Vol. 20, Issue 3). https://doi.org/10.1371/journal.pone.0316747 Jansson, D., Westlander, R., Sandlund, J., West, C. E., Domellöf, M., & Wulff, K. (2025). Behaviour-based movement cut-off points in 3-year old children comparing wrist- with hip-worn actigraphs MW8 and GT3X. In PLOS ONE (No. e0316747; Vol. 20, Issue 3). https://doi.org/10.1371/journal.pone.0316747 10.1371/journal.pone.0316747 urn:nbn:se:umu:diva-233047 oai:DiVA.org:umu-233047 2025 oai:DiVA.org:umu-233047 Österlund, J., Granåsen, G., Bodén, S., Silfverdal, S.-A., Domellöf, M., Winberg, A., & West, C. E. (2024). Revised Swedish infant feeding guidelines are associated with earlier introduction of allergenic foods. In Journal of Allergy and Clinical Immunology (Vol. 153, Issue 2, pp. 461–470). https://doi.org/10.1016/j.jaci.2023.08.037 Österlund, J., Granåsen, G., Bodén, S., Silfverdal, S.-A., Domellöf, M., Winberg, A., & West, C. E. (2024). Revised Swedish infant feeding guidelines are associated with earlier introduction of allergenic foods. In Journal of Allergy and Clinical Immunology (Vol. 153, Issue 2, pp. 461–470). https://doi.org/10.1016/j.jaci.2023.08.037 urn:nbn:se:umu:diva-216206 10.1016/j.jaci.2023.08.037 oai:DiVA.org:umu-216206 2024 oai:DiVA.org:umu-216206 Meander, L., Lindqvist, M., Mogren, I., Sandlund, J., West, C. E., & Domellöf, M. (2021). Physical activity and sedentary time during pregnancy and associations with maternal and fetal health outcomes: an epidemiological study. In BMC Pregnancy and Childbirth (No. 166; Vol. 21, Issue 1). https://doi.org/10.1186/s12884-021-03627-6 Meander, L., Lindqvist, M., Mogren, I., Sandlund, J., West, C. E., & Domellöf, M. (2021). Physical activity and sedentary time during pregnancy and associations with maternal and fetal health outcomes: an epidemiological study. In BMC Pregnancy and Childbirth (No. 166; Vol. 21, Issue 1). https://doi.org/10.1186/s12884-021-03627-6 urn:nbn:se:umu:diva-181575 10.1186/s12884-021-03627-6 oai:DiVA.org:umu-181575 2021 oai:DiVA.org:umu-181575 Yuan, B., Bignert, A., Andersson, P. L., West, C. E., Domellöf, M., & Bergman, Å. (2024). Polychlorinated alkanes in paired blood serum and breast milk in a Swedish cohort study : Matrix dependent partitioning differences compared to legacy POPs. In Environment International (No. 108440; Vol. 183). https://doi.org/10.1016/j.envint.2024.108440 Yuan, B., Bignert, A., Andersson, P. L., West, C. E., Domellöf, M., & Bergman, Å. (2024). Polychlorinated alkanes in paired blood serum and breast milk in a Swedish cohort study : Matrix dependent partitioning differences compared to legacy POPs. In Environment International (No. 108440; Vol. 183). https://doi.org/10.1016/j.envint.2024.108440 urn:nbn:se:oru:diva-111020 10.1016/j.envint.2024.108440 oai:DiVA.org:oru-111020 2024 oai:DiVA.org:oru-111020 Lundkvist, E., Stoltz Sjöström, E., Lundberg, R., Silfverdal, S.-A., West, C. E., & Domellöf, M. (2021). Fruit pouch consumption and dietary patterns related to BMIz at 18 months of age. In Nutrients (No. 2265; Vol. 13, Issue 7). https://doi.org/10.3390/nu13072265 Lundkvist, E., Stoltz Sjöström, E., Lundberg, R., Silfverdal, S.-A., West, C. E., & Domellöf, M. (2021). Fruit pouch consumption and dietary patterns related to BMIz at 18 months of age. In Nutrients (No. 2265; Vol. 13, Issue 7). https://doi.org/10.3390/nu13072265 10.3390/nu13072265 urn:nbn:se:umu:diva-185572 oai:DiVA.org:umu-185572 2021 oai:DiVA.org:umu-185572 Bodén, S., Lindam, A., Domellöf, M., Venter, C., & West, C. E. (2023). Diet diversity in pregnancy and early allergic manifestations in the offspring. In Clinical and Experimental Allergy (Vol. 53, Issue 9, pp. 963–968). https://doi.org/10.1111/cea.14346 Bodén, S., Lindam, A., Domellöf, M., Venter, C., & West, C. E. (2023). Diet diversity in pregnancy and early allergic manifestations in the offspring. In Clinical and Experimental Allergy (Vol. 53, Issue 9, pp. 963–968). https://doi.org/10.1111/cea.14346 10.1111/cea.14346 oai:DiVA.org:umu-210213 2023 oai:DiVA.org:umu-210213 Kelderer, F., Granåsen, G., Holmlund, S., Silfverdal, S.-A., Bamberg, H., Mommers, M., Penders, J., Domellöf, M., Mogren, I., & West, C. E. (2025). Respiratory morbidity before and during the COVID-19 pandemic from birth to 18 months in a Swedish birth cohort. In Journal of Allergy and Clinical Immunology (Vol. 155, Issue 4, pp. 1214-1223.e10). https://doi.org/10.1016/j.jaci.2024.12.1080 Kelderer, F., Granåsen, G., Holmlund, S., Silfverdal, S.-A., Bamberg, H., Mommers, M., Penders, J., Domellöf, M., Mogren, I., & West, C. E. (2025). Respiratory morbidity before and during the COVID-19 pandemic from birth to 18 months in a Swedish birth cohort. In Journal of Allergy and Clinical Immunology (Vol. 155, Issue 4, pp. 1214-1223.e10). https://doi.org/10.1016/j.jaci.2024.12.1080 urn:nbn:se:umu:diva-234871 10.1016/j.jaci.2024.12.1080 oai:DiVA.org:umu-234871 2025 oai:DiVA.org:umu-234871 West, C. E., Lif Holgerson, P., Chmielewska, A., Lundberg-Ulfsdotter, R., Lagerqvist, C., Stoltz Sjöström, E., Wulff, K., Sandström, O., Mogren, I., Silfverdal, S.-A., & Domellöf, M. (2025). NorthPop: a prospective population-based birth cohort study. In BMC Public Health (No. 2171; Vol. 25, Issue 1). https://doi.org/10.1186/s12889-025-23561-y West, C. E., Lif Holgerson, P., Chmielewska, A., Lundberg-Ulfsdotter, R., Lagerqvist, C., Stoltz Sjöström, E., Wulff, K., Sandström, O., Mogren, I., Silfverdal, S.-A., & Domellöf, M. (2025). NorthPop: a prospective population-based birth cohort study. In BMC Public Health (No. 2171; Vol. 25, Issue 1). https://doi.org/10.1186/s12889-025-23561-y urn:nbn:se:umu:diva-241898 10.1186/s12889-025-23561-y oai:DiVA.org:umu-241898 2025 oai:DiVA.org:umu-241898 Fredriksson, E., Bodén, S., Domellöf, M., & West, C. E. (2023). Fruit pouch consumption does not associate with early manifestations of allergic disease. In Nutrients (No. 4318; Vol. 15, Issue 20). https://doi.org/10.3390/nu15204318 Fredriksson, E., Bodén, S., Domellöf, M., & West, C. E. (2023). Fruit pouch consumption does not associate with early manifestations of allergic disease. In Nutrients (No. 4318; Vol. 15, Issue 20). https://doi.org/10.3390/nu15204318 10.3390/nu15204318 urn:nbn:se:umu:diva-216664 oai:DiVA.org:umu-216664 2023 oai:DiVA.org:umu-216664