Data for: FSH receptor N680S genotype-guided choice of gonadotropin increases cumulative pregnancy and live birth rate after in vitro fertilization
https://doi.org/10.5878/gb77-1e72
Pseudonymised data on n=1466 women who underwent assisted reproduction. N=475 women are genotyped for a follicle-stimulating hormone receptor polymorphism (N680S, rs6166), while the remainder (n=991) are non-genotyped but treated controls. The data includes background data, as well as parameters related to the women's treatment for assisted reproduction. Genotype data for the aforementioned polymorphism is available for the n=475 women. In vitro data (pmol cAMP/mg total protein) for COS-1 cells stimulated with two types of hormones is available. Extracellular cAMP was measured by ELISA and normalized against the amount of total protein in the cell lysate.
Citation and access
Citation and access
Data access level:
Creator/Principal investigator(s):
- Emir Henic – Lund University
- Hannah Nenonen – Lund University
- Aleksander Giwercman – Lund University
- Margareta Laczna Kitlinski – Scanian University Hospital, Malmö
- Yvonne Giwercman – Lund University
Research principal:
Data contains personal data:
Yes
Type of personal data:
Pseudonymised parameters related to the women's treatment for assisted reproduction and background data.
Code key exists:
Yes
Sensitive personal data:
Yes
Citation:
Language:
Method and outcome
Method and outcome
Population:
The population consists of women living in southern Sweden who have undergone fertility treatment.
Time method:
Study design:
- Observational study
Time period(s) investigated:
Variables:
25
Number of individuals/objects:
1466
Geographic coverage
Geographic coverage
Geographic location:
Administrative information
Administrative information
Responsible department/unit:
Translational medicine / molecular genetic reproductive medicine
Ethical Review
Ethical Review
Reviewer:
- Lund Ethical Review Board
Registration number:
2016-467; 2023-05465-02; 2024-01055-02
Topic and keywords
Topic and keywords
CESSDA topic classification:
Swedish Standard Classification of Research Subjects 2025:
Publications
Publications
Citation:
Hjelmér, I., Nilsson, M., Henic, E., Jedrzejczak, P., Nenonen, H., Ozegowska, K., Giwercman, A., Laczna Kitlinski, M., & Lundberg Giwercman, Y. (2025). FSH receptor N680S genotype-guided gonadotropin choice increases cumulative pregnancy and live birth rates after in vitro fertilization. In Frontiers in Endocrinology (Vol. 16, p. 10). https://doi.org/10.3389/fendo.2025.1576090
Metadata
Metadata
Version 1
