https://researchdata.se/en/catalogue Search results en Autoantibodies (autoAbs) against type I interferons (IFNs) can severely compromise antiviral defense in a broad range of severe viral infections. To investigate the mechanisms underlying autoantibody development, we performed paired scRNA-seq and scBCR-seq on sorted IFN-α2-positive and IFN-α2-negative B cells, together with scRNA-seq of other non-B immune cells. PBMCs were obtained from eight aIFN⁺ patients with severe COVID-19, five aIFN⁻ patients with severe COVID-19, five patients with APS-1, and ten healthy donors. The dataset is comprised of about 150 files and a total size of 810 GB. Mon, 28 Sep 2026 06:35:02 GMT https://researchdata.se/en/catalogue/dataset/2026-253 https://researchdata.se/en/catalogue/dataset/2026-253 Karolinska Institutet Rui Sun Qiang Pan-Hammarström