Cluster-randomized trial on Akwenda Intervention program for children and young people with cerebral palsy in Uganda: functioning and activity outcomes

• Hans Forssberg - Karolinska Institutet - Department of Women's and Children's Health

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• Angelina Kakooza Mwesige - Makerere University, Kampala, Uganda - Department of Pediatrics and Child Health

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• Karolinska Institutet - Department Women's and Children's Health

• Karolinska Institutet

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• 2017-05474

• Access to data is restricted

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• English

• Individual/Patient

A total of 100 children and young people with CP aged 2-23 years were included (52 males). Most were from a population-based cohort identified in a three-stage screening at the IM-HDSS in 20152 which has been followed and studied in a series of articles.10,13-16 An additional group of 27 children between ages 2-6 years were conveniently sampled to include younger participants and achieve statistical power. CP diagnosis was confirmed by a child neurologist using the European CP surveillance definition.

• Longitudinal

• Registry-based randomised controlled trial (R-RCT)

This was a quasi-randomized, controlled, single-blinded study on a cohort of children and young people with CP in the Iganga-Mayuge Health and Demographic Surveillance Site (IM-HDSS) covering a population of approximately 80,000 inhabitants . The CP cohort was divided in two arms: one receiving the Akwenda Intervention program, and the other serving as control waiting to receive the intervention the following year. Children with seizures in both groups were provided anti-seizure medications. Outcomes were assessed prior to and after the intervention period.

• Total universe/Complete enumeration

Population based study on all children and young people with cerebral palsy aged 2-23 living at the IM-HDSS.

• 2021-07-01 - 2022-11-30

40

100

No

94%

Of the 100 participants enrolled in the trial, 94 completed the study: 48 in the intervention group and 46 in the control group. In the intervention group two participants withdrew while three children in the control group were deceased at follow-up and one child withdrew.

• Numeric

• Uganda

Iganga-Mayuge district, Uganda

Municipality

Municipality

Department of Women's and Children's Health

• Angelina Kakooza-Mwesige - Makerere University, Kampala, Uganda - Department of Pediatrics and Child Health

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Other - UNCST, SS-5173

The study was approved by the Uganda National Council for Science and Technology

• Medication and treatment
• Physical fitness and exercise

• Neurology
• Pediatrics
• Occupational therapy
• Physiotherapy

• Cerebral palsy