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Supplementary information for dissertation "CAR-T cells for Immunotherapy of Cancer"

https://doi.org/10.57804/t9yy-1d15
Supplementary information on the dissertation "CAR T cells for Immunotherapy of Cancer", with the following list of sub-papers: 1. Single-cell RNA analysis reveal subpopulations of CAR T cells correlating with response in lymphoma patients 2. Preclinical evaluation of CAR20(NAP)-T cells for B cell lymphoma 3. Complementary-determining region clustering causes CAR-T cell dysfunction 4. Armed CAR-T cells directed against IL13Rα2 show potent activity against glioblastoma Differentially expressed genes between responders and non-responders (Fc -1.2 ≤ or ≤ 1.2). The dataset was originally published in DiVA and moved to SND in 2024.
Ladda ner data och dokumentation (4 filer / 3.2 MiB)

Datafiler

  • SUPPLEMENTARY_INFO_Paper1.pdf
    696.91 KiB
  • SUPPLEMENTARY_INFO_Paper3.pdf
    2.18 MiB
  • SUPPLEMENTARY_INFO_Paper4_Table8.txt
    14.33 KiB
  • SUPPLEMENTARY_INFO_Paper4.pdf
    337.45 KiB

Citering och åtkomst

Tillgänglighetsnivå:

Skapare/primärforskare:

  • Tina Sarén - Uppsala universitet

Forskningshuvudman:

Data innehåller personuppgifter:

Nej

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Metod och utfall

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Administrativ information

URN:

urn:nbn:se:uu:diva-468713Öppnas i en ny tabb

URN:

urn:nbn:se:uu:diva-468834Öppnas i en ny tabb

URN:

urn:nbn:se:uu:diva-468835Öppnas i en ny tabb

URN:

urn:nbn:se:uu:diva-468712Öppnas i en ny tabb

Ämnesområde och nyckelord

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Relationer

Ersätter:

https://nbn-resolving.org/urn:nbn:se:uu:diva-468713Öppnas i en ny tabb

Ersätter:

https://nbn-resolving.org/urn:nbn:se:uu:diva-468712Öppnas i en ny tabb

Ersätter:

https://nbn-resolving.org/urn:nbn:se:uu:diva-468834Öppnas i en ny tabb

Ersätter:

https://nbn-resolving.org/urn:nbn:se:uu:diva-468835Öppnas i en ny tabb

Publikationer

Citering:

Sarén, T., Saronio, G., Marti Torrell, P. et al. Complementarity-determining region clustering may cause CAR-T cell dysfunction. Nat Commun 14, 4732 (2023). https://doi.org/10.1038/s41467-023-40303-zÖppnas i en ny tabb

Citering:

Sarén, T. 2022. CAR T cells for Immunotherapy of Cancer. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1814. 57 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-1430-3

Citering:

Sarén T, Ramachandran M, Gammelgård G, Lövgren T, Mirabello C, Björklund ÅK, Wikström K, Hashemi J, Freyhult E, Ahlström H, Amini RM, Hagberg H, Loskog A, Enblad G, Essand M. Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients. Clin Cancer Res. 2023 Oct 13;29(20):4139-4152. doi: 10.1158/1078-0432.CCR-23-0178. PMID: 37540566; PMCID: PMC10570681.

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