Human Disease Blood Atlas: A Pan-Disease Blood Proteome Resource

This dataset and metadata record describes the plasma proteome profiles used to create a detailed map of protein levels in human blood across major diseases. The open-access version of this dataset, protein levels per disease, is available on the Human Protein Atlas (www.proteinatlas.org (http://www.proteinatlas.orgÖppnas i en ny tabb) ). This dataset includes plasma profiles of disease-specific groups and longitudinal analyses of healthy individuals. All plasma samples are EDTA plasma, collected following the ethical principles of the Declaration of Helsinki with informed consent. Comprehensive blood protein profiling across diseases and healthy individuals was conducted using the Proximity Extension Assay. The Olink Explore 1.5 and Olink Explore HT platforms were utilized for this analysis. The study includes four distinct datasets:- Pan-Disease: Plasma samples from 6,121 individuals across 59 diseases. (Olink Explore 1536) - Wellness: 100 individuals followed longitudinally over two years. (Olink HT) - BAMSE: 100 individuals followed from childhood to early adulthood. (Olink HT) - UCAN: Approximately 2,000 plasma samples from breast, ovarian, prostate, colorectal, and lung cancer patients. (Olink HT) Pan-Disease Cohorts:- Plasma samples from 6,121 individuals across 59 diseases, classified into cardiovascular, metabolic, cancer, psychiatric, autoimmune, infectious, and pediatric diseases. - Plasma samples from approximately 2,000 patients diagnosed with breast, ovarian, prostate, colorectal, and lung cancer patients from the U-CAN biobank (Uppsala and Umeå Universities, Uppsala Biobank, Biobanken Norr). Longitudinal Cohorts of Healthy Individuals:- 100 individuals (aged 50-65) followed at six visits over two years (Swedish SciLifeLab SCAPIS Wellness Profiling - S3WP program, recruited from SCAPIS). - 100 individuals followed at four-time points from childhood to early adulthood (Swedish population-based birth cohort BAMSE). Access and Data Availability (Important information)This entry is a metadata-only record describing the Human Disease Blood Atlas plasma proteomics datasets (Olink Explore 1.5 / Olink Explore HT, Proximity Extension Assay). Individual-level raw NPX values and individual-level clinical metadata cannot be shared due to ethical, consent, and governance constraints across the contributing cohorts. The open-access version of the resource is available via the Human Protein Atlas and provides group-level/aggregated protein abundance summaries with limited clinical metadata to prevent identification of individuals. What is available publicly - Aggregated / group-level protein abundance per disease (and other pre-defined groupings) through the Human Protein Atlas. What is not available - Individual-level raw NPX (or any row-level per-sample matrix) - Individual-level clinical metadata, coded IDs, or linkable subject-level information Requests for access Requests for individual-level NPX data cannot be granted through this record. Researchers are instead encouraged to: - Use the publicly available aggregated resource for hypothesis generation; and/or - Pursue a collaboration with the relevant cohort custodian for a clearly defined analysis where outputs can be shared only at an aggregated level, in line with cohort governance and participant consent. Such requests must be directed to the appropriate cohort owner (listed as a co-author on the associated Science publication, https://www.science.org/doi/10.1126/science.adx2678Öppnas i en ny tabb).