Human Disease Blood Atlas: A Pan-Disease Blood Proteome Resource

This dataset and metadata record describes the plasma proteome profiles used to create a detailed map of protein levels in human blood across major diseases. The open-access version of this dataset, protein levels per disease, is available on the Human Protein Atlas (www.proteinatlas.org (http://www.proteinatlas.orgÖppnas i en ny tabb) ). This dataset includes plasma profiles of disease-specific groups and longitudinal analyses of healthy individuals. All plasma samples are EDTA plasma, collected following the ethical principles of the Declaration of Helsinki with informed consent. Comprehensive blood protein profiling across diseases and healthy individuals was conducted using the Proximity Extension Assay. The Olink Explore 1.5 and Olink Explore HT platforms were utilized for this analysis. The study includes four distinct datasets:- Pan-Disease: Plasma samples from 6,121 individuals across 59 diseases. (Olink Explore 1536) - Wellness: 100 individuals followed longitudinally over two years. (Olink HT) - BAMSE: 100 individuals followed from childhood to early adulthood. (Olink HT) - UCAN: Approximately 2,000 plasma samples from breast, ovarian, prostate, colorectal, and lung cancer patients. (Olink HT) Pan-Disease Cohorts:- Plasma samples from 6,121 individuals across 59 diseases, classified into cardiovascular, metabolic, cancer, psychiatric, autoimmune, infectious, and pediatric diseases. - Plasma samples from approximately 2,000 patients diagnosed with breast, ovarian, prostate, colorectal, and lung cancer patients from the U-CAN biobank (Uppsala and Umeå Universities, Uppsala Biobank, Biobanken Norr). Longitudinal Cohorts of Healthy Individuals:- 100 individuals (aged 50-65) followed at six visits over two years (Swedish SciLifeLab SCAPIS Wellness Profiling - S3WP program, recruited from SCAPIS). - 100 individuals followed at four-time points from childhood to early adulthood (Swedish population-based birth cohort BAMSE). Access and Data AvailabilityThe Human Protein Atlas website provides public access to the plasma proteome protein levels. Notably, the raw data and clinical metadata described in this metadata record, including plasma proteome profiles obtained using Olink HT and Olink Explore platforms, are available only upon request for validation purposes. Access to the complete or subsets of the dataset is subject to an internal review process to ensure compliance with ethical considerations, patient consent agreements, and applicable regulations. Each sub-dataset follows its respective ethical guidelines and participant information documents governing data-sharing terms. Researchers interested in accessing the data must submit a request, which will be reviewed to ensure the proposed use aligns with the original consent and ethical approvals. If approved, the researchers will be granted controlled access to the relevant datasets, which may include data sharing or publication restrictions to protect participant privacy and uphold the terms of the original consent agreements.